Diabetes: 57 (8)

August 01 2008; volume 57 issue 8

Metabolism

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Obese Mice Lacking Inducible Nitric Oxide Synthase Are Sensitized to the Metabolic Actions of Peroxisome Proliferator–Activated Receptor-γ Agonism
Patrice Dallaire, Kerstin Bellmann, Mathieu Laplante, Stéphanie Gélinas, Carolina Centeno-Baez, Patrice Penfornis, Marie-Line Peyot, Martin G. Latour, Julien Lamontagne, Maria E. Trujillo, Philipp E. Scherer, Marc Prentki, Yves Deshaies and André Marette

Diabetes 2008 Aug; 57 (8): 1999-2011. https://doi.org/10.2337/db08-0540

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Partial Resistance to Peroxisome Proliferator–Activated Receptor-α Agonists in ZDF Rats Is Associated With Defective Hepatic Mitochondrial Metabolism
Santhosh Satapati, TianTeng He, Takeshi Inagaki, Matthew Potthoff, Matthew E. Merritt, Victoria Esser, David J. Mangelsdorf, Steven A. Kliewer, Jeffrey D. Browning and Shawn C. Burgess

Diabetes 2008 Aug; 57 (8): 2012-2021. https://doi.org/10.2337/db08-0226

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Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue With Lipoprotein Particle Number and Size in Type 2 Diabetes
Susan Sam, Steven Haffner, Michael H. Davidson, Ralph B. D'Agostino, Steven Feinstein, George Kondos, Alfonso Perez and Theodore Mazzone

Diabetes 2008 Aug; 57 (8): 2022-2027. https://doi.org/10.2337/db08-0157

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Cannabinoid Type 1 Receptor Blockade Promotes Mitochondrial Biogenesis Through Endothelial Nitric Oxide Synthase Expression in White Adipocytes
Laura Tedesco, Alessandra Valerio, Cristina Cervino, Annalisa Cardile, Claudio Pagano, Roberto Vettor, Renato Pasquali, Michele O. Carruba, Giovanni Marsicano, Beat Lutz, Uberto Pagotto and Enzo Nisoli

Diabetes 2008 Aug; 57 (8): 2028-2036. https://doi.org/10.2337/db07-1623

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Consequences of Lipid Droplet Coat Protein Downregulation in Liver CellsAbnormal Lipid Droplet Metabolism and Induction of Insulin Resistance
Ming Bell, Hong Wang, Hui Chen, John C. McLenithan, Da-Wei Gong, Rong-Zee Yang, Daozhan Yu, Susan K. Fried, Michael J. Quon, Constantine Londos and Carole Sztalryd

Diabetes 2008 Aug; 57 (8): 2037-2045. https://doi.org/10.2337/db07-1383

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Arcuate Glucagon-Like Peptide 1 Receptors Regulate Glucose Homeostasis but Not Food Intake
Darleen A. Sandoval, Didier Bagnol, Stephen C. Woods, David A. D'Alessio and Randy J. Seeley

Diabetes 2008 Aug; 57 (8): 2046-2054. https://doi.org/10.2337/db07-1824

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The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation
Victoria A. Payne, Neil Grimsey, Antoinette Tuthill, Sam Virtue, Sarah L. Gray, Edoardo Dalla Nora, Robert K. Semple, Stephen O'Rahilly and Justin J. Rochford

Diabetes 2008 Aug; 57 (8): 2055-2060. https://doi.org/10.2337/db08-0184

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Hypothalamic Protein Kinase C Regulates Glucose Production
Rachel Ross, Penny Y.T. Wang, Madhu Chari, Carol K.L. Lam, Liora Caspi, Hiraku Ono, Evan D. Muse, Xiaosong Li, Roger Gutierrez-Juarez, Peter E. Light, Gary J. Schwartz, Luciano Rossetti and Tony K.T. Lam

Diabetes 2008 Aug; 57 (8): 2061-2065. https://doi.org/10.2337/db08-0206

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Signal Transduction

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siRNA-Mediated Reduction of Inhibitor of Nuclear Factor-κB Kinase Prevents Tumor Necrosis Factor-α–Induced Insulin Resistance in Human Skeletal Muscle
Reginald L. Austin, Anna Rune, Karim Bouzakri, Juleen R. Zierath and Anna Krook

Diabetes 2008 Aug; 57 (8): 2066-2073. https://doi.org/10.2337/db07-0763

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Autocrine IGF-1 Action in Adipocytes Controls Systemic IGF-1 Concentrations and Growth
Nora Klöting, Linda Koch, Thomas Wunderlich, Matthias Kern, Karen Ruschke, Wilhelm Krone, Jens C. Brüning and Matthias Blüher

Diabetes 2008 Aug; 57 (8): 2074-2082. https://doi.org/10.2337/db07-1538

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Impact of Oxidative Stress and Peroxisome Proliferator–Activated Receptor γ Coactivator-1α in Hepatic Insulin Resistance
Naoki Kumashiro, Yoshifumi Tamura, Toyoyoshi Uchida, Takeshi Ogihara, Yoshio Fujitani, Takahisa Hirose, Hideki Mochizuki, Ryuzo Kawamori and Hirotaka Watada

Diabetes 2008 Aug; 57 (8): 2083-2091. https://doi.org/10.2337/db08-0144

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Obesity Studies

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Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats
Ling Shen, Patrick Tso, Stephen C. Woods, Deborah J. Clegg, Kyna L. Barber, Katherine Carey and Min Liu

Diabetes 2008 Aug; 57 (8): 2092-2098. https://doi.org/10.2337/db08-0291

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Immunology and Transplantation

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T-Cell Promiscuity in Autoimmune Diabetes
Li Li, Bo Wang, Jeffrey A. Frelinger and Roland Tisch

Diabetes 2008 Aug; 57 (8): 2099-2106. https://doi.org/10.2337/db08-0383

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Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin–Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes
Gilles Besin, Simon Gaudreau, Michaël Ménard, Chantal Guindi, Gilles Dupuis and Abdelaziz Amrani

Diabetes 2008 Aug; 57 (8): 2107-2117. https://doi.org/10.2337/db08-0171

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Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice
Junyan Han, Jinxin Zhong, Wenzhong Wei, Ying Wang, Yafei Huang, Ping Yang, Sharad Purohit, Zheng Dong, Mong-Heng Wang, Jin-Xiong She, Feili Gong, David M. Stern and Cong-Yi Wang

Diabetes 2008 Aug; 57 (8): 2118-2127. https://doi.org/10.2337/db07-1499

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Pancreatic Duct Cells in Human Islet Cell Preparations Are a Source of Angiogenic Cytokines Interleukin-8 and Vascular Endothelial Growth Factor
Babak Movahedi, Conny Gysemans, Daniel Jacobs-Tulleneers-Thevissen, Chantal Mathieu and Daniel Pipeleers

Diabetes 2008 Aug; 57 (8): 2128-2136. https://doi.org/10.2337/db07-1705

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Islet Studies

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PANIC-ATTAC: A Mouse Model for Inducible and Reversible β-Cell Ablation
Zhao V. Wang, James Mu, Todd D. Schraw, Laurent Gautron, Joel K. Elmquist, Bei B. Zhang, Michael Brownlee and Philipp E. Scherer

Diabetes 2008 Aug; 57 (8): 2137-2148. https://doi.org/10.2337/db07-1631

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Pathophysiology

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Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2
Ricardo Rodríguez-Calvo, Lucía Serrano, Teresa Coll, Norman Moullan, Rosa M. Sánchez, Manuel Merlos, Xavier Palomer, Juan C. Laguna, Liliane Michalik, Walter Wahli and Manuel Vázquez-Carrera

Diabetes 2008 Aug; 57 (8): 2149-2157. https://doi.org/10.2337/db08-0176

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Altered Calcium Homeostasis Does Not Explain the Contractile Deficit of Diabetic Cardiomyopathy
Lin Zhang, Mark B. Cannell, Anthony R.J. Phillips, Garth J.S. Cooper and Marie-Louise Ward

Diabetes 2008 Aug; 57 (8): 2158-2166. https://doi.org/10.2337/db08-0140

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Complications

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Exposure to Maternal Diabetes Induces Salt-Sensitive Hypertension and Impairs Renal Function in Adult Rat Offspring
Touria Nehiri, Jean-Paul Duong Van Huyen, Mélanie Viltard, Céline Fassot, Didier Heudes, Nicole Freund, Georges Deschênes, Pascal Houillier, Patrick Bruneval and Martine Lelièvre-Pégorier

Diabetes 2008 Aug; 57 (8): 2167-2175. https://doi.org/10.2337/db07-0780

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Heritability of Proliferative Diabetic Retinopathy
Kustaa Hietala, Carol Forsblom, Paula Summanen and Per-Henrik Groop

Diabetes 2008 Aug; 57 (8): 2176-2180. https://doi.org/10.2337/db07-1495

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Protein Kinase C-δ Mediates Neuronal Apoptosis in the Retinas of Diabetic Rats via the Akt Signaling Pathway
Young-Hee Kim, Yoon-Sook Kim, Chang-Hwan Park, In-Yong Chung, Ji-Myong Yoo, Jae-Geun Kim, Byung-Ju Lee, Sang-Soo Kang, Gyeong-Jae Cho and Wan-Sung Choi

Diabetes 2008 Aug; 57 (8): 2181-2190. https://doi.org/10.2337/db07-1431

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Angiotensin II Type 1 Receptor Signaling Contributes to Synaptophysin Degradation and Neuronal Dysfunction in the Diabetic Retina
Toshihide Kurihara, Yoko Ozawa, Norihiro Nagai, Kei Shinoda, Kousuke Noda, Yutaka Imamura, Kazuo Tsubota, Hideyuki Okano, Yuichi Oike and Susumu Ishida

Diabetes 2008 Aug; 57 (8): 2191-2198. https://doi.org/10.2337/db07-1281

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Pharmacology and Therapeutics

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Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice
Alicia G. Gómez-Valadés, Andrés Méndez-Lucas, Anna Vidal-Alabró, Francese X. Blasco, Miguel Chillon, Ramon Bartrons, Jordi Bermúdez and José C. Perales

Diabetes 2008 Aug; 57 (8): 2199-2210. https://doi.org/10.2337/db07-1087

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Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice
Carina P. Tan, Yue Feng, Yun-Ping Zhou, George J. Eiermann, Aleksandr Petrov, Changyou Zhou, Songnian Lin, Gino Salituro, Peter Meinke, Ralph Mosley, Taro E. Akiyama, Monica Einstein, Sanjeev Kumar, Joel P. Berger, Sander G. Mills, Nancy A. Thornberry, Lihu Yang and Andrew D. Howard

Diabetes 2008 Aug; 57 (8): 2211-2219. https://doi.org/10.2337/db08-0130

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Genetics

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Association Analysis in African Americans of European-Derived Type 2 Diabetes Single Nucleotide Polymorphisms From Whole-Genome Association Studies
Joshua P. Lewis, Nicholette D. Palmer, Pamela J. Hicks, Michele M. Sale, Carl D. Langefeld, Barry I. Freedman, Jasmin Divers and Donald W. Bowden

Diabetes 2008 Aug; 57 (8): 2220-2225. https://doi.org/10.2337/db07-1319

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Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians
Maggie C.Y. Ng, Kyong Soo Park, Bermseok Oh, Claudia H.T. Tam, Young Min Cho, Hyoung Doo Shin, Vincent K.L. Lam, Ronald C.W. Ma, Wing Yee So, Yoon Shin Cho, Hyung-Lae Kim, Hong Kyu Lee, Juliana C.N. Chan and Nam H. Cho

Diabetes 2008 Aug; 57 (8): 2226-2233. https://doi.org/10.2337/db07-1583

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Role of the Transcription Factor Sox4 in Insulin Secretion and Impaired Glucose Tolerance
Michelle Goldsworthy, Alison Hugill, Helen Freeman, Emma Horner, Kenju Shimomura, Debora Bogani, Guido Pieles, Vesna Mijat, Ruth Arkell, Shoumo Bhattacharya, Frances M. Ashcroft and Roger D. Cox

Diabetes 2008 Aug; 57 (8): 2234-2244. https://doi.org/10.2337/db07-0337

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Common Variation in the Fat Mass and Obesity-Associated (FTO) Gene Confers Risk of Obesity and Modulates BMI in the Chinese Population
Yi-Cheng Chang, Pi-Hua Liu, Wei-Jei Lee, Tien-Jyun Chang, Yi-Der Jiang, Hung-Yuan Li, Shan-Shan Kuo, Kuang-Chin Lee and Lee-Ming Chuang

Diabetes 2008 Aug; 57 (8): 2245-2252. https://doi.org/10.2337/db08-0377

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The Common P446L Polymorphism in GCKR Inversely Modulates Fasting Glucose and Triglyceride Levels and Reduces Type 2 Diabetes Risk in the DESIR Prospective General French Population
Martine Vaxillaire, Christine Cavalcanti-Proença, Aurélie Dechaume, Jean Tichet, Michel Marre, Beverley Balkau and Philippe Froguel

Diabetes 2008 Aug; 57 (8): 2253-2257. https://doi.org/10.2337/db07-1807

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Table of Contents

Metabolism

Signal Transduction

Obesity Studies

Immunology and Transplantation

Islet Studies

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics

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