Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

Junyan Han; Jinxin Zhong; Wenzhong Wei; Ying Wang; Yafei Huang; Ping Yang; Sharad Purohit; Zheng Dong; Mong-Heng Wang; Jin-Xiong She; Feili Gong; David M. Stern; Cong-Yi Wang

doi:10.2337/db07-1499

Immunology and Transplantation

Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

Junyan Han1,
Jinxin Zhong1,
Wenzhong Wei1,
Ying Wang1,
Yafei Huang1,
Ping Yang1,
Sharad Purohit1,
Zheng Dong2,
Mong-Heng Wang3,
Jin-Xiong She1,
Feili Gong4,
David M. Stern5 and
Cong-Yi Wang1

¹Center for Biotechnology and Genomic Medicine, Department of Pathology, Medical College of Georgia, Augusta, Georgia
²Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
³Department of Physiology, Medical College of Georgia, Augusta, Georgia
⁴Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China
⁵University of Cincinnati College of Medicine, Cincinnati, Ohio

Corresponding author: Cong-Yi Wang, cwang{at}mcg.edu

Diabetes 2008 Aug; 57(8): 2118-2127. https://doi.org/10.2337/db07-1499

Article Information

vol. 57 no. 8 2118-2127

DOI

https://doi.org/10.2337/db07-1499

PubMed

18477810

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

May 7, 2008
November 7, 2007
Published in print July 28, 2008.
Published online ahead of print May 13, 2008.

Article Versions

Previous version (May 13, 2008 - 13:02).
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DIABETES

Author Information

Junyan Han1,
Jinxin Zhong1,
Wenzhong Wei1,
Ying Wang1,
Yafei Huang1,
Ping Yang1,
Sharad Purohit1,
Zheng Dong2,
Mong-Heng Wang3,
Jin-Xiong She1,
Feili Gong4,
David M. Stern5 and
Cong-Yi Wang1

¹Center for Biotechnology and Genomic Medicine, Department of Pathology, Medical College of Georgia, Augusta, Georgia
²Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
³Department of Physiology, Medical College of Georgia, Augusta, Georgia
⁴Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China
⁵University of Cincinnati College of Medicine, Cincinnati, Ohio

Corresponding author: Cong-Yi Wang, cwang{at}mcg.edu

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