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Immunology and Transplantation

Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice

  1. Junyan Han1,
  2. Jinxin Zhong1,
  3. Wenzhong Wei1,
  4. Ying Wang1,
  5. Yafei Huang1,
  6. Ping Yang1,
  7. Sharad Purohit1,
  8. Zheng Dong2,
  9. Mong-Heng Wang3,
  10. Jin-Xiong She1,
  11. Feili Gong4,
  12. David M. Stern5 and
  13. Cong-Yi Wang1
  1. 1Center for Biotechnology and Genomic Medicine, Department of Pathology, Medical College of Georgia, Augusta, Georgia
  2. 2Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
  3. 3Department of Physiology, Medical College of Georgia, Augusta, Georgia
  4. 4Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China
  5. 5University of Cincinnati College of Medicine, Cincinnati, Ohio
  1. Corresponding author: Cong-Yi Wang, cwang{at}mcg.edu
Diabetes 2008 Aug; 57(8): 2118-2127. https://doi.org/10.2337/db07-1499
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Article Information

vol. 57 no. 8 2118-2127
DOI 
https://doi.org/10.2337/db07-1499
PubMed 
18477810

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • May 7, 2008
  • November 7, 2007
  • Published in print July 28, 2008.
  • Published online ahead of print May 13, 2008.

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  • Previous version (May 13, 2008 - 13:02).
  • You are viewing the most recent version of this article.
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DIABETES

Author Information

  1. Junyan Han1,
  2. Jinxin Zhong1,
  3. Wenzhong Wei1,
  4. Ying Wang1,
  5. Yafei Huang1,
  6. Ping Yang1,
  7. Sharad Purohit1,
  8. Zheng Dong2,
  9. Mong-Heng Wang3,
  10. Jin-Xiong She1,
  11. Feili Gong4,
  12. David M. Stern5 and
  13. Cong-Yi Wang1
  1. 1Center for Biotechnology and Genomic Medicine, Department of Pathology, Medical College of Georgia, Augusta, Georgia
  2. 2Department of Cell Biology and Anatomy, Medical College of Georgia, Augusta, Georgia
  3. 3Department of Physiology, Medical College of Georgia, Augusta, Georgia
  4. 4Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Peoples Republic of China
  5. 5University of Cincinnati College of Medicine, Cincinnati, Ohio
  1. Corresponding author: Cong-Yi Wang, cwang{at}mcg.edu
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Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice
Junyan Han, Jinxin Zhong, Wenzhong Wei, Ying Wang, Yafei Huang, Ping Yang, Sharad Purohit, Zheng Dong, Mong-Heng Wang, Jin-Xiong She, Feili Gong, David M. Stern, Cong-Yi Wang
Diabetes Aug 2008, 57 (8) 2118-2127; DOI: 10.2337/db07-1499

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Extracellular High-Mobility Group Box 1 Acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset in NOD Mice
Junyan Han, Jinxin Zhong, Wenzhong Wei, Ying Wang, Yafei Huang, Ping Yang, Sharad Purohit, Zheng Dong, Mong-Heng Wang, Jin-Xiong She, Feili Gong, David M. Stern, Cong-Yi Wang
Diabetes Aug 2008, 57 (8) 2118-2127; DOI: 10.2337/db07-1499
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  • One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent-Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24
  • Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
  • Differentiating MHC-Dependent and -Independent Mechanisms of Lymph Node Stromal Cell Regulation of Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes
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