Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

Zhong-bin Deng; Anton Poliakov; Robert W. Hardy; Ronald Clements; Cunren Liu; Yuelong Liu; Jianhua Wang; Xiaoyu Xiang; Shuangqin Zhang; Xiaoying Zhuang; Spandan V. Shah; Dongmei Sun; Sue Michalek; William E. Grizzle; Timothy Garvey; Jim Mobley; Huang-Ge Zhang

doi:10.2337/db09-0216

Original Article

Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance

Zhong-bin Deng¹,
Anton Poliakov²,
Robert W. Hardy³,
Ronald Clements⁴,
Cunren Liu¹,
Yuelong Liu¹,
Jianhua Wang¹,
Xiaoyu Xiang¹,
Shuangqin Zhang¹,
Xiaoying Zhuang¹,
Spandan V. Shah¹,
Dongmei Sun¹,
Sue Michalek⁵,
William E. Grizzle³,
Timothy Garvey⁴,
Jim Mobley² and
Huang-Ge Zhang¹,⁶

¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;
²Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama;
³Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Albama;
⁴Department of Nutrition, University of Alabama at Birmingham, Birmingham, Alabama;
⁵Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama;
⁶Birmingham Veterans Administration Medical Center, Birmingham, Alabama.

Corresponding author: Huang-Ge Zhang, huang-ge.zhang{at}ccc.uab.edu.

Diabetes 2009 Nov; 58(11): 2498-2505. https://doi.org/10.2337/db09-0216

Article Information

vol. 58 no. 11 2498-2505

DOI

https://doi.org/10.2337/db09-0216

PubMed

19675137

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Received February 13, 2009
Accepted July 27, 2009
Published in print October 29, 2009.
Published online ahead of print August 12, 2009.

Article Versions

Previous version (August 12, 2009 - 07:47).
You are viewing the most recent version of this article.

© 2009 American Diabetes Association Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

Author Information

Zhong-bin Deng¹,
Anton Poliakov²,
Robert W. Hardy³,
Ronald Clements⁴,
Cunren Liu¹,
Yuelong Liu¹,
Jianhua Wang¹,
Xiaoyu Xiang¹,
Shuangqin Zhang¹,
Xiaoying Zhuang¹,
Spandan V. Shah¹,
Dongmei Sun¹,
Sue Michalek⁵,
William E. Grizzle³,
Timothy Garvey⁴,
Jim Mobley² and
Huang-Ge Zhang¹,⁶

¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;
²Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama;
³Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Albama;
⁴Department of Nutrition, University of Alabama at Birmingham, Birmingham, Alabama;
⁵Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama;
⁶Birmingham Veterans Administration Medical Center, Birmingham, Alabama.

Corresponding author: Huang-Ge Zhang, huang-ge.zhang{at}ccc.uab.edu.

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2009 to February 2021

Rendering graph...

	Abstract	Full	Pdf
Aug 2009	310	0	124
Sep 2009	118	0	152
Oct 2009	369	8	113
Nov 2009	1717	73	150
Dec 2009	361	29	40
Jan 2010	247	48	42
Feb 2010	144	86	34
Mar 2010	103	169	24
Apr 2010	95	117	20
May 2010	106	128	22
Jun 2010	127	101	18
Jul 2010	104	74	15
Aug 2010	123	77	13
Sep 2010	58	124	10
Oct 2010	75	71	12
Nov 2010	37	70	45
Dec 2010	49	48	33
Jan 2011	44	51	38
Feb 2011	22	41	22
Mar 2011	41	56	36
Apr 2011	37	28	28
May 2011	40	49	28
Jun 2011	32	33	36
Jul 2011	38	25	38
Aug 2011	35	34	35
Sep 2011	51	57	50
Oct 2011	32	31	41
Nov 2011	63	26	34
Dec 2011	71	35	31
Jan 2012	50	51	38
Feb 2012	34	37	30
Mar 2012	49	61	40
Apr 2012	45	45	35
May 2012	49	43	30
Jun 2012	25	50	37
Jul 2012	36	46	44
Aug 2012	29	77	34
Sep 2012	35	55	34
Oct 2012	32	34	35
Nov 2012	47	48	44
Dec 2012	45	36	31
Jan 2013	26	57	48
Feb 2013	52	66	30
Mar 2013	33	46	38
Apr 2013	38	47	37
May 2013	54	57	41
Jun 2013	27	28	53
Jul 2013	20	36	43
Aug 2013	15	53	61
Sep 2013	26	46	21
Oct 2013	46	62	27
Nov 2013	40	67	29
Dec 2013	29	50	23
Jan 2014	23	48	18
Feb 2014	22	53	34
Mar 2014	26	66	34
Apr 2014	23	51	21
May 2014	11	55	35
Jun 2014	35	50	23
Jul 2014	50	62	39
Aug 2014	27	43	39
Sep 2014	27	59	32
Oct 2014	18	58	41
Nov 2014	20	42	25
Dec 2014	41	36	32
Jan 2015	38	87	49
Feb 2015	25	61	28
Mar 2015	28	127	42
Apr 2015	33	74	42
May 2015	29	88	43
Jun 2015	22	81	28
Jul 2015	30	56	29
Aug 2015	33	80	30
Sep 2015	57	63	36
Oct 2015	54	77	37
Nov 2015	29	72	47
Dec 2015	43	57	37
Jan 2016	40	64	45
Feb 2016	34	78	54
Mar 2016	48	52	35
Apr 2016	46	75	52
May 2016	31	60	32
Jun 2016	19	69	55
Jul 2016	18	81	42
Aug 2016	13	98	35
Sep 2016	35	87	40
Oct 2016	20	92	54
Nov 2016	22	103	52
Dec 2016	7	97	46
Jan 2017	19	79	47
Feb 2017	22	75	47
Mar 2017	10	92	45
Apr 2017	17	64	39
May 2017	16	80	34
Jun 2017	9	59	44
Jul 2017	8	65	27
Aug 2017	14	80	22
Sep 2017	16	65	52
Oct 2017	11	111	49
Nov 2017	21	113	64
Dec 2017	14	100	32
Jan 2018	12	70	38
Feb 2018	17	72	36
Mar 2018	13	97	49
Apr 2018	13	158	41
May 2018	10	107	39
Jun 2018	19	76	21
Jul 2018	14	72	40
Aug 2018	8	51	34
Sep 2018	6	73	21
Oct 2018	15	116	52
Nov 2018	20	97	48
Dec 2018	8	108	25
Jan 2019	15	109	46
Feb 2019	24	71	43
Mar 2019	29	103	62
Apr 2019	20	62	39
May 2019	20	65	43
Jun 2019	16	69	46
Jul 2019	21	66	47
Aug 2019	21	49	41
Sep 2019	9	57	42
Oct 2019	8	107	48
Nov 2019	25	58	41
Dec 2019	11	37	33
Jan 2020	21	50	26
Feb 2020	15	78	51
Mar 2020	20	60	48
Apr 2020	24	46	43
May 2020	15	42	36
Jun 2020	9	50	35
Jul 2020	13	43	27
Aug 2020	9	33	23
Sep 2020	9	48	36
Oct 2020	20	80	56
Nov 2020	19	73	60
Dec 2020	15	57	44
Jan 2021	10	88	55
Feb 2021	14	31	24