Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

Nicole Soranzo; Serena Sanna; Eleanor Wheeler; Christian Gieger; Dörte Radke; Josée Dupuis; Nabila Bouatia-Naji; Claudia Langenberg; Inga Prokopenko; Elliot Stolerman; Manjinder S. Sandhu; Matthew M. Heeney; Joseph M. Devaney; Muredach P. Reilly; Sally L. Ricketts

doi:10.2337/db10-0502

Pharmacology and Therapeutics

Common Variants at 10 Genomic Loci Influence Hemoglobin A_1C Levels via Glycemic and Nonglycemic Pathways

Nicole Soranzo, ¹, ²,
Serena Sanna, ³,
Eleanor Wheeler, ¹,
Christian Gieger, ⁴,
Dörte Radke, ⁵,
Josée Dupuis, ⁶, ⁷,
Nabila Bouatia-Naji, ⁸,
Claudia Langenberg, ⁹,
Inga Prokopenko, ¹⁰, ¹¹,
Elliot Stolerman, ¹², ¹³, ¹⁴,
Manjinder S. Sandhu, ⁹, ¹⁵, ¹⁶,
Matthew M. Heeney, ¹⁷,
Joseph M. Devaney, ¹⁸,
Muredach P. Reilly, ¹⁹, ²⁰ and
Sally L. Ricketts, ¹⁵*

Corresponding authors: Jose C. Florez, jcflorez{at}partners.org; Manuela Uda, manuela.uda{at}inn.cnr.it; Nicholas J. Wareham, nick.wareham{at}mrc-epid.cam.ac.uk; Inês Barroso, ib1{at}sanger.ac.uk; and James B. Meigs, jmeigs{at}partners.org.

N.S., S.S., E.W., C.G., and D.R. contributed equally to this study.

Diabetes 2010 Dec; 59(12): 3229-3239. https://doi.org/10.2337/db10-0502

Article Information

vol. 59 no. 12 3229-3239

DOI

https://doi.org/10.2337/db10-0502

PubMed

20858683

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Received April 11, 2010
Accepted September 5, 2010
Published in print November 29, 2010.
Published online ahead of print September 21, 2010.

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Previous version (September 21, 2010 - 05:58).
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© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

Author Information

Nicole Soranzo, ¹, ²,
Serena Sanna, ³,
Eleanor Wheeler, ¹,
Christian Gieger, ⁴,
Dörte Radke, ⁵,
Josée Dupuis, ⁶, ⁷,
Nabila Bouatia-Naji, ⁸,
Claudia Langenberg, ⁹,
Inga Prokopenko, ¹⁰, ¹¹,
Elliot Stolerman, ¹², ¹³, ¹⁴,
Manjinder S. Sandhu, ⁹, ¹⁵, ¹⁶,
Matthew M. Heeney, ¹⁷,
Joseph M. Devaney, ¹⁸,
Muredach P. Reilly, ¹⁹, ²⁰ and
Sally L. Ricketts, ¹⁵*

Corresponding authors: Jose C. Florez, jcflorez{at}partners.org; Manuela Uda, manuela.uda{at}inn.cnr.it; Nicholas J. Wareham, nick.wareham{at}mrc-epid.cam.ac.uk; Inês Barroso, ib1{at}sanger.ac.uk; and James B. Meigs, jmeigs{at}partners.org.

N.S., S.S., E.W., C.G., and D.R. contributed equally to this study.

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