Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways

Nicole Soranzo; Serena Sanna; Eleanor Wheeler; Christian Gieger; Dörte Radke; Josée Dupuis; Nabila Bouatia-Naji; Claudia Langenberg; Inga Prokopenko; Elliot Stolerman; Manjinder S. Sandhu; Matthew M. Heeney; Joseph M. Devaney; Muredach P. Reilly; Sally L. Ricketts

doi:10.2337/db10-0502

Pharmacology and Therapeutics

Common Variants at 10 Genomic Loci Influence Hemoglobin A_1C Levels via Glycemic and Nonglycemic Pathways

Nicole Soranzo, ¹, ²,
Serena Sanna, ³,
Eleanor Wheeler, ¹,
Christian Gieger, ⁴,
Dörte Radke, ⁵,
Josée Dupuis, ⁶, ⁷,
Nabila Bouatia-Naji, ⁸,
Claudia Langenberg, ⁹,
Inga Prokopenko, ¹⁰, ¹¹,
Elliot Stolerman, ¹², ¹³, ¹⁴,
Manjinder S. Sandhu, ⁹, ¹⁵, ¹⁶,
Matthew M. Heeney, ¹⁷,
Joseph M. Devaney, ¹⁸,
Muredach P. Reilly, ¹⁹, ²⁰ and
Sally L. Ricketts, ¹⁵*

Corresponding authors: Jose C. Florez, jcflorez{at}partners.org; Manuela Uda, manuela.uda{at}inn.cnr.it; Nicholas J. Wareham, nick.wareham{at}mrc-epid.cam.ac.uk; Inês Barroso, ib1{at}sanger.ac.uk; and James B. Meigs, jmeigs{at}partners.org.

N.S., S.S., E.W., C.G., and D.R. contributed equally to this study.

Diabetes 2010 Dec; 59(12): 3229-3239. https://doi.org/10.2337/db10-0502

Article Information

vol. 59 no. 12 3229-3239

DOI

https://doi.org/10.2337/db10-0502

PubMed

20858683

Published By

American Diabetes Association

Print ISSN

0012-1797

Online ISSN

1939-327X

History

Received April 11, 2010
Accepted September 5, 2010
Published in print November 29, 2010.
Published online ahead of print September 21, 2010.

Article Versions

Previous version (September 21, 2010 - 05:58).
You are viewing the most recent version of this article.

© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

Author Information

Nicole Soranzo, ¹, ²,
Serena Sanna, ³,
Eleanor Wheeler, ¹,
Christian Gieger, ⁴,
Dörte Radke, ⁵,
Josée Dupuis, ⁶, ⁷,
Nabila Bouatia-Naji, ⁸,
Claudia Langenberg, ⁹,
Inga Prokopenko, ¹⁰, ¹¹,
Elliot Stolerman, ¹², ¹³, ¹⁴,
Manjinder S. Sandhu, ⁹, ¹⁵, ¹⁶,
Matthew M. Heeney, ¹⁷,
Joseph M. Devaney, ¹⁸,
Muredach P. Reilly, ¹⁹, ²⁰ and
Sally L. Ricketts, ¹⁵*

Corresponding authors: Jose C. Florez, jcflorez{at}partners.org; Manuela Uda, manuela.uda{at}inn.cnr.it; Nicholas J. Wareham, nick.wareham{at}mrc-epid.cam.ac.uk; Inês Barroso, ib1{at}sanger.ac.uk; and James B. Meigs, jmeigs{at}partners.org.

N.S., S.S., E.W., C.G., and D.R. contributed equally to this study.

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: October 2010 to September 2020

Rendering graph...

	Abstract	Full	Pdf
Oct 2010	504	0	352
Nov 2010	318	0	160
Dec 2010	941	74	101
Jan 2011	220	38	39
Feb 2011	231	56	57
Mar 2011	195	129	46
Apr 2011	167	109	39
May 2011	120	117	26
Jun 2011	124	150	31
Jul 2011	128	132	24
Aug 2011	129	125	23
Sep 2011	95	92	35
Oct 2011	111	101	43
Nov 2011	136	119	29
Dec 2011	117	73	56
Jan 2012	120	71	53
Feb 2012	112	45	55
Mar 2012	93	53	46
Apr 2012	76	59	31
May 2012	97	46	33
Jun 2012	56	38	40
Jul 2012	65	52	41
Aug 2012	64	40	23
Sep 2012	73	47	27
Oct 2012	90	68	37
Nov 2012	61	46	40
Dec 2012	63	44	21
Jan 2013	61	39	22
Feb 2013	55	36	21
Mar 2013	73	55	38
Apr 2013	85	43	37
May 2013	73	42	24
Jun 2013	59	39	11
Jul 2013	42	21	14
Aug 2013	51	37	17
Sep 2013	55	24	22
Oct 2013	58	31	30
Nov 2013	70	32	33
Dec 2013	69	43	15
Jan 2014	70	39	23
Feb 2014	57	47	31
Mar 2014	57	53	32
Apr 2014	22	59	13
May 2014	51	50	20
Jun 2014	40	59	15
Jul 2014	52	37	18
Aug 2014	35	36	36
Sep 2014	52	63	54
Oct 2014	54	37	27
Nov 2014	60	43	29
Dec 2014	45	30	21
Jan 2015	54	26	16
Feb 2015	49	34	22
Mar 2015	52	46	25
Apr 2015	38	26	16
May 2015	50	31	23
Jun 2015	50	45	40
Jul 2015	48	36	19
Aug 2015	27	43	28
Sep 2015	87	32	27
Oct 2015	56	34	42
Nov 2015	32	28	23
Dec 2015	72	37	24
Jan 2016	80	45	35
Feb 2016	147	51	29
Mar 2016	67	23	25
Apr 2016	40	40	33
May 2016	33	73	41
Jun 2016	19	82	54
Jul 2016	31	79	44
Aug 2016	20	79	39
Sep 2016	46	63	15
Oct 2016	29	84	34
Nov 2016	23	55	25
Dec 2016	24	72	16
Jan 2017	23	78	20
Feb 2017	34	186	19
Mar 2017	18	131	31
Apr 2017	12	171	36
May 2017	7	129	20
Jun 2017	11	67	25
Jul 2017	13	72	19
Aug 2017	11	53	9
Sep 2017	9	66	24
Oct 2017	10	53	19
Nov 2017	23	73	21
Dec 2017	19	59	18
Jan 2018	11	57	19
Feb 2018	22	49	11
Mar 2018	27	52	22
Apr 2018	20	55	25
May 2018	9	73	13
Jun 2018	22	57	16
Jul 2018	19	63	32
Aug 2018	9	34	18
Sep 2018	16	42	20
Oct 2018	14	134	23
Nov 2018	6	172	39
Dec 2018	12	113	18
Jan 2019	9	92	52
Feb 2019	6	71	58
Mar 2019	12	80	41
Apr 2019	9	73	27
May 2019	12	80	44
Jun 2019	7	86	66
Jul 2019	8	122	40
Aug 2019	7	148	44
Sep 2019	5	400	66
Oct 2019	13	102	36
Nov 2019	12	45	28
Dec 2019	8	36	37
Jan 2020	10	82	26
Feb 2020	5	44	14
Mar 2020	2	35	35
Apr 2020	3	31	18
May 2020	4	59	21
Jun 2020	1	70	18
Jul 2020	4	36	15
Aug 2020	8	59	39
Sep 2020	4	40	6