Table of Contents

Original Article

• New Methodologies and Databases

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    Local Non-Esterified Fatty Acids Correlate With Inflammation in Atheroma Plaques of Patients With Type 2 Diabetes

    Sebastián Mas, Roxana Martínez-Pinna, Jose Luis Martín-Ventura, Raul Pérez, Dulcenombre Gomez-Garre, Alberto Ortiz, Arturo Fernandez-Cruz, Fernando Vivanco and Jesús Egido

    Diabetes 2010 Jun; 59 (6): 1292-1301. https://doi.org/10.2337/db09-0848

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• Metabolism

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    Molecular Characterization of Insulin-Mediated Suppression of Hepatic Glucose Production In Vivo

    Christopher J. Ramnanan, Dale S. Edgerton, Noelia Rivera, Jose Irimia-Dominguez, Ben Farmer, Doss W. Neal, Margaret Lautz, E. Patrick Donahue, Catalina M. Meyer, Peter J. Roach and Alan D. Cherrington

    Diabetes 2010 Jun; 59 (6): 1302-1311. https://doi.org/10.2337/db09-1625

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    PTEN Inhibition Improves Muscle Regeneration in Mice Fed a High-Fat Diet

    Zhaoyong Hu, Huiling Wang, In Hee Lee, Swati Modi, Xiaonan Wang, Jie Du and William E. Mitch

    Diabetes 2010 Jun; 59 (6): 1312-1320. https://doi.org/10.2337/db09-1155

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    Glycerol-3-Phosphate Acyltransferase 1 Deficiency in ob/ob Mice Diminishes Hepatic Steatosis but Does Not Protect Against Insulin Resistance or Obesity

    Angela A. Wendel, Lei O. Li, Yue Li, Gary W. Cline, Gerald I. Shulman and Rosalind A. Coleman

    Diabetes 2010 Jun; 59 (6): 1321-1329. https://doi.org/10.2337/db09-1380

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    Effect of Endogenous GLP-1 on Insulin Secretion in Type 2 Diabetes

    Marzieh Salehi, Benedict Aulinger, Ronald L. Prigeon and David A. D'Alessio

    Diabetes 2010 Jun; 59 (6): 1330-1337. https://doi.org/10.2337/db09-1253

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    Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

    Vanessa P. Houde, Sophie Brûlé, William T. Festuccia, Pierre-Gilles Blanchard, Kerstin Bellmann, Yves Deshaies and André Marette

    Diabetes 2010 Jun; 59 (6): 1338-1348. https://doi.org/10.2337/db09-1324

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    Mechanisms of Insulin Resistance After Insulin-Induced Hypoglycemia in Humans: The Role of Lipolysis

    Paola Lucidi, Paolo Rossetti, Francesca Porcellati, Simone Pampanelli, Paola Candeloro, Anna Marinelli Andreoli, Gabriele Perriello, Geremia B. Bolli and Carmine G. Fanelli

    Diabetes 2010 Jun; 59 (6): 1349-1357. https://doi.org/10.2337/db09-0745

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    TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

    Ding An, Taro Toyoda, Eric B. Taylor, Haiyan Yu, Nobuharu Fujii, Michael F. Hirshman and Laurie J. Goodyear

    Diabetes 2010 Jun; 59 (6): 1358-1365. https://doi.org/10.2337/db09-1266

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    Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

    Debby P.Y. Koonen, Miranda M.Y. Sung, Cindy K.C. Kao, Vernon W. Dolinsky, Timothy R. Koves, Olga Ilkayeva, René L. Jacobs, Dennis E. Vance, Peter E. Light, Deborah M. Muoio, Maria Febbraio and Jason R.B. Dyck

    Diabetes 2010 Jun; 59 (6): 1366-1375. https://doi.org/10.2337/db09-1142

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    Lipocalin-2 Deficiency Impairs Thermogenesis and Potentiates Diet-Induced Insulin Resistance in Mice

    Hong Guo, Daozhong Jin, Yuanyuan Zhang, Wendy Wright, Merlijn Bazuine, David A. Brockman, David A. Bernlohr and Xiaoli Chen

    Diabetes 2010 Jun; 59 (6): 1376-1385. https://doi.org/10.2337/db09-1735

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• Signal Transduction

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    Activation of AMP-Activated Protein Kinase Inhibits Oxidized LDL-Triggered Endoplasmic Reticulum Stress In Vivo

    Yunzhou Dong, Miao Zhang, Shuangxi Wang, Bin Liang, Zhengxing Zhao, Chao Liu, Mingyuan Wu, Hyoung Chul Choi, Timothy J. Lyons and Ming-Hui Zou

    Diabetes 2010 Jun; 59 (6): 1386-1396. https://doi.org/10.2337/db09-1637

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    Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

    Anil Kumar, John C. Lawrence, Dae Young Jung, Hwi Jin Ko, Susanna R. Keller, Jason K. Kim, Mark A. Magnuson and Thurl E. Harris

    Diabetes 2010 Jun; 59 (6): 1397-1406. https://doi.org/10.2337/db09-1061

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• Obesity Studies

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    Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals

    Leslie A. Consitt, Jill A. Bell, Timothy R. Koves, Deborah M. Muoio, Matthew W. Hulver, Kimberly R. Haynie, G. Lynis Dohm and Joseph A. Houmard

    Diabetes 2010 Jun; 59 (6): 1407-1415. https://doi.org/10.2337/db09-1704

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    Critical Role of the Mesenteric Depot Versus Other Intra-abdominal Adipose Depots in the Development of Insulin Resistance in Young Rats

    Karyn J. Catalano, Darko Stefanovski and Richard N. Bergman

    Diabetes 2010 Jun; 59 (6): 1416-1423. https://doi.org/10.2337/db08-0675

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    Deletion of the α-Arrestin Protein Txnip in Mice Promotes Adiposity and Adipogenesis While Preserving Insulin Sensitivity

    William A. Chutkow, Andreas L. Birkenfeld, Jonathan D. Brown, Hui-Young Lee, David W. Frederick, Jun Yoshioka, Parth Patwari, Romy Kursawe, Samuel W. Cushman, Jorge Plutzky, Gerald I. Shulman, Varman T. Samuel and Richard T. Lee

    Diabetes 2010 Jun; 59 (6): 1424-1434. https://doi.org/10.2337/db09-1212

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• Islet Studies

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    Ectopic Expression of E2F1 Stimulates β-Cell Proliferation and Function

    Gael Grouwels, Ying Cai, Inge Hoebeke, Gunter Leuckx, Yves Heremans, Ulrike Ziebold, Geert Stangé, Marie Chintinne, Zhidong Ling, Daniel Pipeleers, Harry Heimberg and Mark Van de Casteele

    Diabetes 2010 Jun; 59 (6): 1435-1444. https://doi.org/10.2337/db09-1295

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• Immunology and Transplantation

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    Naturally Arising Human CD4 T-Cells That Recognize Islet Autoantigens and Secrete Interleukin-10 Regulate Proinflammatory T-Cell Responses via Linked Suppression

    Timothy I.M. Tree, Jennifer Lawson, Hannah Edwards, Ania Skowera, Sefina Arif, Bart O. Roep and Mark Peakman

    Diabetes 2010 Jun; 59 (6): 1451-1460. https://doi.org/10.2337/db09-0503

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    Prevention of Diabetes by FTY720-Mediated Stabilization of Peri-Islet Tertiary Lymphoid Organs

    Cristina Penaranda, Qizhi Tang, Nancy H. Ruddle and Jeffrey A. Bluestone

    Diabetes 2010 Jun; 59 (6): 1461-1468. https://doi.org/10.2337/db09-1129

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    Caspase Inhibitor Therapy Synergizes With Costimulation Blockade to Promote Indefinite Islet Allograft Survival

    Juliet A. Emamaullee, Joy Davis, Rena Pawlick, Christian Toso, Shaheed Merani, Sui-Xiong Cai, Ben Tseng and A.M. James Shapiro

    Diabetes 2010 Jun; 59 (6): 1469-1477. https://doi.org/10.2337/db09-0502

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    Idd9.2 and Idd9.3 Protective Alleles Function in CD4⁺ T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8⁺ T-Cells

    Emma E. Hamilton-Williams, S.B. Justin Wong, Xavier Martinez, Daniel B. Rainbow, Kara M. Hunter, Linda S. Wicker and Linda A. Sherman

    Diabetes 2010 Jun; 59 (6): 1478-1486. https://doi.org/10.2337/db09-1801

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• Pathophysiology

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    Platelet Tissue Factor Synthesis in Type 2 Diabetic Patients Is Resistant to Inhibition by Insulin

    Anja J. Gerrits, Cornelis A. Koekman, Timon W. van Haeften and Jan Willem N. Akkerman

    Diabetes 2010 Jun; 59 (6): 1487-1495. https://doi.org/10.2337/db09-1008

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    High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism

    Federico Biscetti, Giuseppe Straface, Raimondo De Cristofaro, Stefano Lancellotti, Paola Rizzo, Vincenzo Arena, Egidio Stigliano, Giovanni Pecorini, Kensuke Egashira, Giulia De Angelis, Giovanni Ghirlanda and Andrea Flex

    Diabetes 2010 Jun; 59 (6): 1496-1505. https://doi.org/10.2337/db09-1507

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• Complications

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    Cardiac-Specific IGF-1 Receptor Transgenic Expression Protects Against Cardiac Fibrosis and Diastolic Dysfunction in a Mouse Model of Diabetic Cardiomyopathy

    Karina Huynh, Julie R. McMullen, Tracey L. Julius, Joon Win Tan, Jane E. Love, Nelly Cemerlang, Helen Kiriazis, Xiao-Jun Du and Rebecca H. Ritchie

    Diabetes 2010 Jun; 59 (6): 1512-1520. https://doi.org/10.2337/db09-1456

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    Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

    Sachin A. Paranjape, Owen Chan, Wanling Zhu, Adam M. Horblitt, Ewan C. McNay, James A. Cresswell, Jonathan S. Bogan, Rory J. McCrimmon and Robert S. Sherwin

    Diabetes 2010 Jun; 59 (6): 1521-1527. https://doi.org/10.2337/db10-0014

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    Inhibition of Reactive Oxygen Species by Lovastatin Downregulates Vascular Endothelial Growth Factor Expression and Ameliorates Blood-Retinal Barrier Breakdown in db/db MiceRole of NADPH Oxidase 4

    Jingming Li, Joshua J. Wang, Qiang Yu, Kai Chen, Kalyankar Mahadev and Sarah X. Zhang

    Diabetes 2010 Jun; 59 (6): 1528-1538. https://doi.org/10.2337/db09-1057

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• Genetics

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    MTNR1B G24E Variant Associates With BMI and Fasting Plasma Glucose in the General Population in Studies of 22,142 Europeans

    Ehm A. Andersson, Birgitte Holst, Thomas Sparsø, Niels Grarup, Karina Banasik, Johan Holmkvist, Torben Jørgensen, Knut Borch-Johnsen, Kristoffer L. Egerod, Torsten Lauritzen, Thorkild I.A. Sørensen, Amélie Bonnefond, David Meyre, Philippe Froguel, Thue W. Schwartz, Oluf Pedersen and Torben Hansen

    Diabetes 2010 Jun; 59 (6): 1539-1548. https://doi.org/10.2337/db09-1757

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