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Table of Contents

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September 01 2010; volume 59 issue 9

Perspectives in Diabetes

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    Antigen-Specific Immunotherapy for Type 1 Diabetes: Maximizing the Potential
    Mark Peakman and Matthias von Herrath
    Diabetes 2010 Sep; 59 (9): 2087-2093. https://doi.org/10.2337/db10-0630
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    Recent Advances and Prospects in the Differentiation of Pancreatic Cells From Human Embryonic Stem Cells
    Josué Kunjom Mfopou, Bing Chen, Lina Sui, Karen Sermon and Luc Bouwens
    Diabetes 2010 Sep; 59 (9): 2094-2101. https://doi.org/10.2337/db10-0439
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Commentaries

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    Pancreatic Islet Transplants and IDO: When Starving the Enemy Does You Good
    Laura Crisa
    Diabetes 2010 Sep; 59 (9): 2102-2104. https://doi.org/10.2337/db10-0919
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    Obesity and Insulin Resistance: An Ongoing Saga
    Sun H. Kim and Gerald Reaven
    Diabetes 2010 Sep; 59 (9): 2105-2106. https://doi.org/10.2337/db10-0766
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Metabolism

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    Ablation of 4E-BP1/2 Prevents Hyperglycemia-Mediated Induction of VEGF Expression in the Rodent Retina and in Müller Cells in Culture
    Tabitha L. Schrufer, David A. Antonetti, Nahum Sonenberg, Scot R. Kimball, Thomas W. Gardner and Leonard S. Jefferson
    Diabetes 2010 Sep; 59 (9): 2107-2116. https://doi.org/10.2337/db10-0148
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    Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance
    Joris Hoeks, Noud A. van Herpen, Marco Mensink, Esther Moonen-Kornips, Denis van Beurden, Matthijs K.C. Hesselink and Patrick Schrauwen
    Diabetes 2010 Sep; 59 (9): 2117-2125. https://doi.org/10.2337/db10-0519
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    Sleep Restriction for 1 Week Reduces Insulin Sensitivity in Healthy Men
    Orfeu M. Buxton, Milena Pavlova, Emily W. Reid, Wei Wang, Donald C. Simonson and Gail K. Adler
    Diabetes 2010 Sep; 59 (9): 2126-2133. https://doi.org/10.2337/db09-0699
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    Kinetics of Contraction-Induced GLUT4 Translocation in Skeletal Muscle Fibers From Living Mice
    Hans P.M.M. Lauritzen, Henrik Galbo, Taro Toyoda and Laurie J. Goodyear
    Diabetes 2010 Sep; 59 (9): 2134-2144. https://doi.org/10.2337/db10-0233
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    Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans
    Jenny Tong, Ronald L. Prigeon, Harold W. Davis, Martin Bidlingmaier, Steven E. Kahn, David E. Cummings, Matthias H. Tschöp and David D'Alessio
    Diabetes 2010 Sep; 59 (9): 2145-2151. https://doi.org/10.2337/db10-0504
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    Nitric Oxide Synthesis Is Reduced in Subjects With Type 2 Diabetes and Nephropathy
    Paolo Tessari, Diego Cecchet, Alessandra Cosma, Monica Vettore, Anna Coracina, Renato Millioni, Elisabetta Iori, Lucia Puricelli, Angelo Avogaro and Monica Vedovato
    Diabetes 2010 Sep; 59 (9): 2152-2159. https://doi.org/10.2337/db09-1772
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    Glucose-Dependent Insulinotropic Polypeptide May Enhance Fatty Acid Re-esterification in Subcutaneous Abdominal Adipose Tissue in Lean Humans
    Meena Asmar, Lene Simonsen, Sten Madsbad, Bente Stallknecht, Jens Juul Holst and Jens Bülow
    Diabetes 2010 Sep; 59 (9): 2160-2163. https://doi.org/10.2337/db10-0098
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Obesity Studies

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    Short-Term Overfeeding May Induce Peripheral Insulin Resistance Without Altering Subcutaneous Adipose Tissue Macrophages in Humans
    Charmaine S. Tam, Alexander Viardot, Karine Clément, Joan Tordjman, Katherine Tonks, Jerry R. Greenfield, Lesley V. Campbell, Dorit Samocha-Bonet and Leonie K. Heilbronn
    Diabetes 2010 Sep; 59 (9): 2164-2170. https://doi.org/10.2337/db10-0162
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    Increased Brain Fatty Acid Uptake in Metabolic Syndrome
    Anna Karmi, Patricia Iozzo, Antti Viljanen, Jussi Hirvonen, Barbara A. Fielding, Kirsi Virtanen, Vesa Oikonen, Jukka Kemppainen, Tapio Viljanen, Letizia Guiducci, Merja Haaparanta-Solin, Kjell Någren, Olof Solin and Pirjo Nuutila
    Diabetes 2010 Sep; 59 (9): 2171-2177. https://doi.org/10.2337/db09-0138
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Islet Studies

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    β-Cell Failure in Diet-Induced Obese Mice Stratified According to Body Weight Gain: Secretory Dysfunction and Altered Islet Lipid Metabolism Without Steatosis or Reduced β-Cell Mass
    Marie-Line Peyot, Emilie Pepin, Julien Lamontagne, Martin G. Latour, Bader Zarrouki, Roxane Lussier, Marco Pineda, Thomas L. Jetton, S.R. Murthy Madiraju, Erik Joly and Marc Prentki
    Diabetes 2010 Sep; 59 (9): 2178-2187. https://doi.org/10.2337/db09-1452
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    Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Improves β-Cell Function Under Stress
    Diana Gurevitch, Sigalit Boura-Halfon, Roi Isaac, Galit Shahaf, Moti Alberstein, Denise Ronen, Eli C. Lewis and Yehiel Zick
    Diabetes 2010 Sep; 59 (9): 2188-2197. https://doi.org/10.2337/db09-0890
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    Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets
    Reshma Ramracheya, Caroline Ward, Makoto Shigeto, Jonathan N. Walker, Stefan Amisten, Quan Zhang, Paul R. Johnson, Patrik Rorsman and Matthias Braun
    Diabetes 2010 Sep; 59 (9): 2198-2208. https://doi.org/10.2337/db09-1505
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    Targeted Disruption of Pancreatic-Derived Factor (PANDER, FAM3B) Impairs Pancreatic β-Cell Function
    Claudia E. Robert-Cooperman, Jason R. Carnegie, Camella G. Wilson, Jichun Yang, Joshua R. Cook, Jianmei Wu, Robert A. Young, Bryan A. Wolf and Brant R. Burkhardt
    Diabetes 2010 Sep; 59 (9): 2209-2218. https://doi.org/10.2337/db09-1552
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Immunology and Transplantation

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    Local Expression of Indoleamine 2,3 Dioxygenase in Syngeneic Fibroblasts Significantly Prolongs Survival of an Engineered Three-Dimensional Islet Allograft
    Reza B. Jalili, Farshad Forouzandeh, Alireza Moeen Rezakhanlou, Ryan Hartwell, Abelardo Medina, Garth L. Warnock, Bagher Larijani and Aziz Ghahary
    Diabetes 2010 Sep; 59 (9): 2219-2227. https://doi.org/10.2337/db09-1560
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    Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Diabetes
    Chunyan Zhang, Miao Wang, Jeremy J. Racine, Hongjun Liu, Chia-Lei Lin, Indu Nair, Joyce Lau, Yu-An Cao, Ivan Todorov, Mark Atkinson and Defu Zeng
    Diabetes 2010 Sep; 59 (9): 2228-2236. https://doi.org/10.2337/db10-0450
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    Inflammatory Tendencies and Overproduction of IL-17 in the Colon of Young NOD Mice Are Counteracted With Diet Change
    Catharina Alam, Suvi Valkonen, Vindhya Palagani, Jari Jalava, Erkki Eerola and Arno Hänninen
    Diabetes 2010 Sep; 59 (9): 2237-2246. https://doi.org/10.2337/db10-0147
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    Immune Cell–Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin
    Marvin Lin, Na Yin, Barbara Murphy, M. Edward Medof, Stephan Segerer, Peter S. Heeger and Bernd Schröppel
    Diabetes 2010 Sep; 59 (9): 2247-2252. https://doi.org/10.2337/db10-0044
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    A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
    Andrea Vergani, Francesca D'Addio, Mollie Jurewicz, Alessandra Petrelli, Toshihiko Watanabe, Kaifeng Liu, Kenneth Law, Christian Schuetz, Michele Carvello, Elena Orsenigo, Shaoping Deng, Scott J. Rodig, Javeed M. Ansari, Carlo Staudacher, Reza Abdi, John Williams, James Markmann, Mark Atkinson, Mohamed H. Sayegh and Paolo Fiorina
    Diabetes 2010 Sep; 59 (9): 2253-2264. https://doi.org/10.2337/db09-1264
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    Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2rγnull Ins2Akita Mice
    Michael A. Brehm, Rita Bortell, Philip diIorio, Jean Leif, Joseph Laning, Amy Cuthbert, Chaoxing Yang, Mary Herlihy, Lisa Burzenski, Bruce Gott, Oded Foreman, Alvin C. Powers, Dale L. Greiner and Leonard D. Shultz
    Diabetes 2010 Sep; 59 (9): 2265-2270. https://doi.org/10.2337/db10-0323
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Pathophysiology

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    Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
    Kelly A. Diggs-Andrews, Xuezhao Zhang, Zhentao Song, Dorit Daphna-Iken, Vanessa H. Routh and Simon J. Fisher
    Diabetes 2010 Sep; 59 (9): 2271-2280. https://doi.org/10.2337/db10-0401
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    Age-Period-Cohort Analysis of 1990–2003 Incidence Time Trends of Childhood Diabetes in ItalyThe RIDI Study
    Graziella Bruno, Milena Maule, Franco Merletti, Giulia Novelli, Alberto Falorni, Antonio Iannilli, Lorenzo Iughetti, Emma Altobelli, Giuseppe d'Annunzio, Silvano Piffer, Paolo Pozzilli, Dario Iafusco, Marco Songini, Federico Roncarolo, Sonia Toni, Flavia Carle, Valentino Cherubini and the RIDI Study Group
    Diabetes 2010 Sep; 59 (9): 2281-2287. https://doi.org/10.2337/db10-0151
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    Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis
    Romy Kursawe, Markus Eszlinger, Deepak Narayan, Teresa Liu, Merlijn Bazuine, Anna M.G. Cali, Ebe D'Adamo, Melissa Shaw, Bridget Pierpont, Gerald I. Shulman, Samuel W. Cushman, Arthur Sherman and Sonia Caprio
    Diabetes 2010 Sep; 59 (9): 2288-2296. https://doi.org/10.2337/db10-0113
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Complications

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    Müller Cell-Derived VEGF Is Essential for Diabetes-Induced Retinal Inflammation and Vascular Leakage
    Juanjuan Wang, Xueliang Xu, Michael H. Elliott, Meili Zhu and Yun-Zheng Le
    Diabetes 2010 Sep; 59 (9): 2297-2305. https://doi.org/10.2337/db09-1420
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    The Redox Enzyme p66Shc Contributes to Diabetes and Ischemia-Induced Delay in Cutaneous Wound Healing
    Gian Paolo Fadini, Mattia Albiero, Lisa Menegazzo, Elisa Boscaro, Elisa Pagnin, Elisabetta Iori, Chiara Cosma, Annunziata Lapolla, Vittorio Pengo, Massimo Stendardo, Carlo Agostini, Pier Giuseppe Pelicci, Marco Giorgio and Angelo Avogaro
    Diabetes 2010 Sep; 59 (9): 2306-2314. https://doi.org/10.2337/db09-1727
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    Improvement of Retinal Vascular Injury in Diabetic Rats by Statins Is Associated With the Inhibition of Mitochondrial Reactive Oxygen Species Pathway Mediated by Peroxisome Proliferator–Activated Receptor γ Coactivator 1α
    Zhi Zheng, Haibing Chen, Hong Wang, Bilian Ke, Bingqing Zheng, Qian Li, Peiyu Li, Li Su, Qing Gu and Xun Xu
    Diabetes 2010 Sep; 59 (9): 2315-2325. https://doi.org/10.2337/db10-0638
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Genetics

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    Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities
    Oscar Rubio-Cabezas, Jayne A.L. Minton, Iren Kantor, Denise Williams, Sian Ellard and Andrew T. Hattersley
    Diabetes 2010 Sep; 59 (9): 2326-2331. https://doi.org/10.2337/db10-0011
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Online Letters to the Editor

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    Comment on: Robertson (2010) Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass. Diabetes;59:1285–1291
    Paolo Cravedi, Andrea Remuzzi and Giuseppe Remuzzi
    Diabetes 2010 Sep; 59 (9): e13. https://doi.org/10.2337/db10-0848
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    Response to Comment on: Robertson (2010) Islet Transplantation a Decade Later and Strategies for Filling a Half-Full Glass. Diabetes;59:1285–1291
    R. Paul Robertson
    Diabetes 2010 Sep; 59 (9): e14. https://doi.org/10.2337/db10-0881
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    Comment on: Chauhan et al. (2010) Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians. Diabetes;59:2068–2074
    Vipin Gupta and Shah Ebrahim
    Diabetes 2010 Sep; 59 (9): e15. https://doi.org/10.2337/db10-0748
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    Response to Comment on: Chauhan et al. (2010) Impact of Common Variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the Risk of Type 2 Diabetes in 5,164 Indians. Diabetes;59:2068–2074
    Ganesh Chauhan, Charles J. Spurgeon, Rubina Tabassum, Seema Bhaskar, Smita R. Kulkarni, Anubha Mahajan, Sreenivas Chavali, M.V. Kranthi Kumar, Swami Prakash, Om Prakash Dwivedi, Saurabh Ghosh, Chittaranjan S. Yajnik, Nikhil Tandon, Dwaipayan Bharadwaj and Giriraj R. Chandak
    Diabetes 2010 Sep; 59 (9): e16. https://doi.org/10.2337/db10-0868
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    Comment on: Yang et al. (2010) Associations of Hyperglycemia and Insulin Usage With the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry. Diabetes;59:1254–1260
    Bendix Carstensen
    Diabetes 2010 Sep; 59 (9): e17-e18. https://doi.org/10.2337/db10-0777
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    Response to Comment on: Yang et al. (2010) Associations of Hyperglycemia and Insulin Usage With the Risk of Cancer in Type 2 Diabetes: The Hong Kong Diabetes Registry. Diabetes;59:1254–1260
    Xilin Yang, Ronald C.W. Ma and Juliana C.N. Chan
    Diabetes 2010 Sep; 59 (9): e19-e22. https://doi.org/10.2337/db10-0859
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    Comment on: Matsuoka et al. (2010) Regulation of MafA Expression in Pancreatic β-Cells in db/db Mice With Diabetes. Diabetes;59:1709–1720
    Nathan L. Vanderford
    Diabetes 2010 Sep; 59 (9): e23. https://doi.org/10.2337/db10-0684
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September 2010, 59(9)
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