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Table of Contents

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January 01 2011; volume 60 issue 1

Perspectives in Diabetes

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    Stopping Type 1 Diabetes: Attempts to Prevent or Cure Type 1 Diabetes in Man
    Jay S. Skyler and Camillo Ricordi
    Diabetes 2011 Jan; 60 (1): 1-8. https://doi.org/10.2337/db10-1114
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    Diabetic Retinopathy: Targeting Vasoregression
    Hans-Peter Hammes, Yuxi Feng, Frederick Pfister and Michael Brownlee
    Diabetes 2011 Jan; 60 (1): 9-16. https://doi.org/10.2337/db10-0454
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    Toward a More Complete (and Less Controversial) Understanding of Energy Expenditure and Its Role in Obesity Pathogenesis
    Karl J. Kaiyala and Michael W. Schwartz
    Diabetes 2011 Jan; 60 (1): 17-23. https://doi.org/10.2337/db10-0909
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Commentaries

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    Elimination of Hypoglycemia From the Lives of People Affected by Diabetes
    Philip E. Cryer
    Diabetes 2011 Jan; 60 (1): 24-27. https://doi.org/10.2337/db10-1359
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    TRP-ing Down the Path to Insulin Secretion
    Patrick E. MacDonald
    Diabetes 2011 Jan; 60 (1): 28-29. https://doi.org/10.2337/db10-1402
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Metabolism

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    Enhanced Energy Expenditure, Glucose Utilization, and Insulin Sensitivity in VAMP8 Null Mice
    Haihong Zong, Cheng-Chun Wang, Bhavapriya Vaitheesvaran, Irwin J. Kurland, Wanjin Hong and Jeffrey E. Pessin
    Diabetes 2011 Jan; 60 (1): 30-38. https://doi.org/10.2337/db10-0231
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    Naloxone, but Not Valsartan, Preserves Responses to Hypoglycemia After Antecedent HypoglycemiaRole of Metabolic Reprogramming in Counterregulatory Failure
    Michal M. Poplawski, Jason W. Mastaitis and Charles V. Mobbs
    Diabetes 2011 Jan; 60 (1): 39-46. https://doi.org/10.2337/db10-0326
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    Downregulation of Adipose Tissue Fatty Acid Trafficking in ObesityA Driver for Ectopic Fat Deposition?
    Siobhán E. McQuaid, Leanne Hodson, Matthew J. Neville, A. Louise Dennis, Jane Cheeseman, Sandy M. Humphreys, Toralph Ruge, Marjorie Gilbert, Barbara A. Fielding, Keith N. Frayn and Fredrik Karpe
    Diabetes 2011 Jan; 60 (1): 47-55. https://doi.org/10.2337/db10-0867
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    The Portal Theory Supported by Venous Drainage–Selective Fat Transplantation
    Julia M. Rytka, Stephan Wueest, Eugen J. Schoenle and Daniel Konrad
    Diabetes 2011 Jan; 60 (1): 56-63. https://doi.org/10.2337/db10-0697
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    Lipid-Induced Insulin Resistance Affects Women Less Than Men and Is Not Accompanied by Inflammation or Impaired Proximal Insulin Signaling
    Louise D. Høeg, Kim A. Sjøberg, Jacob Jeppesen, Thomas E. Jensen, Christian Frøsig, Jesper B. Birk, Bruno Bisiani, Natalie Hiscock, Henriette Pilegaard, Jørgen F.P. Wojtaszewski, Erik A. Richter and Bente Kiens
    Diabetes 2011 Jan; 60 (1): 64-73. https://doi.org/10.2337/db10-0698
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    Changes in Alcohol Consumption and Subsequent Risk of Type 2 Diabetes in Men
    Michel M. Joosten, Stephanie E. Chiuve, Kenneth J. Mukamal, Frank B. Hu, Henk F.J. Hendriks and Eric B. Rimm
    Diabetes 2011 Jan; 60 (1): 74-79. https://doi.org/10.2337/db10-1052
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    Iron Overload and Diabetes Risk: A Shift From Glucose to Fatty Acid Oxidation and Increased Hepatic Glucose Production in a Mouse Model of Hereditary Hemochromatosis
    Jingyu Huang, Deborah Jones, Bai Luo, Michael Sanderson, Jamie Soto, E. Dale Abel, Robert C. Cooksey and Donald A. McClain
    Diabetes 2011 Jan; 60 (1): 80-87. https://doi.org/10.2337/db10-0593
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    Basal and Insulin Mediated VLDL-Triglyceride Kinetics in Type 2 Diabetic Men
    Lars P. Sørensen, Iben R. Andersen, Esben Søndergaard, Lars C. Gormsen, Ole Schmitz, Jens S. Christiansen and Søren Nielsen
    Diabetes 2011 Jan; 60 (1): 88-96. https://doi.org/10.2337/db10-0564
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    Molecular Mechanisms for Activation of the Agouti-Related Protein and Stimulation of Appetite
    Olha Ilnytska, Adrian M. Stütz, MieJung Park-York, David A. York, David M. Ribnicky, Aamir Zuberi, William T. Cefalu and George Argyropoulos
    Diabetes 2011 Jan; 60 (1): 97-106. https://doi.org/10.2337/db10-0172
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    Hypothalamic Nutrient Sensing Activates a Forebrain-Hindbrain Neuronal Circuit to Regulate Glucose Production In Vivo
    Carol K.L. Lam, Madhu Chari, Guy A. Rutter and Tony K.T. Lam
    Diabetes 2011 Jan; 60 (1): 107-113. https://doi.org/10.2337/db10-0994
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    Intranasal Insulin Enhances Postprandial Thermogenesis and Lowers Postprandial Serum Insulin Levels in Healthy Men
    Christian Benedict, Swantje Brede, Helgi B. Schiöth, Hendrik Lehnert, Bernd Schultes, Jan Born and Manfred Hallschmid
    Diabetes 2011 Jan; 60 (1): 114-118. https://doi.org/10.2337/db10-0329
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Signal Transduction

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    Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice
    Kunitoshi Uchida, Katsuya Dezaki, Boldbaatar Damdindorj, Hitoshi Inada, Tetsuya Shiuchi, Yasuo Mori, Toshihiko Yada, Yasuhiko Minokoshi and Makoto Tominaga
    Diabetes 2011 Jan; 60 (1): 119-126. https://doi.org/10.2337/db10-0276
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    Direct Recruitment of Insulin Receptor and ERK Signaling Cascade to Insulin-Inducible Gene Loci
    Joel D. Nelson, Renée C. LeBoeuf and Karol Bomsztyk
    Diabetes 2011 Jan; 60 (1): 127-137. https://doi.org/10.2337/db09-1806
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    Prep1 Controls Insulin Glucoregulatory Function in Liver by Transcriptional Targeting of SHP1 Tyrosine Phosphatase
    Francesco Oriente, Salvatore Iovino, Serena Cabaro, Angela Cassese, Elena Longobardi, Claudia Miele, Paola Ungaro, Pietro Formisano, Francesco Blasi and Francesco Beguinot
    Diabetes 2011 Jan; 60 (1): 138-147. https://doi.org/10.2337/db10-0860
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    Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells
    Veronika Leiss, Andreas Friebe, Andrea Welling, Franz Hofmann and Robert Lukowski
    Diabetes 2011 Jan; 60 (1): 148-156. https://doi.org/10.2337/db10-0595
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Obesity Studies

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    Mitochondrial Biogenesis and Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α (PGC-1α) Deacetylation by Physical ActivityIntact Adipocytokine Signaling Is Required
    Ling Li, Ruping Pan, Rong Li, Bernd Niemann, Anne-Cathleen Aurich, Ying Chen and Susanne Rohrbach
    Diabetes 2011 Jan; 60 (1): 157-167. https://doi.org/10.2337/db10-0331
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    OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects
    José María Moreno-Navarrete, Francisco J. Ortega, José-Ignacio Rodríguez-Hermosa, Mònica Sabater, Gerard Pardo, Wifredo Ricart and José Manuel Fernández-Real
    Diabetes 2011 Jan; 60 (1): 168-176. https://doi.org/10.2337/db10-0805
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    Nuclear Orphan Receptor TAK1/TR4-Deficient Mice Are Protected Against Obesity-Linked Inflammation, Hepatic Steatosis, and Insulin Resistance
    Hong Soon Kang, Kyoko Okamoto, Yong-Sik Kim, Yukimasa Takeda, Carl D. Bortner, Huaixin Dang, Taira Wada, Wen Xie, Xiao-Ping Yang, Grace Liao and Anton M. Jetten
    Diabetes 2011 Jan; 60 (1): 177-188. https://doi.org/10.2337/db10-0628
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    P-Selectin Glycoprotein Ligand-1 Deficiency Is Protective Against Obesity-Related Insulin Resistance
    Chikage Sato, Kenichi Shikata, Daisho Hirota, Motofumi Sasaki, Shingo Nishishita, Satoshi Miyamoto, Ryo Kodera, Daisuke Ogawa, Atsuhito Tone, Hitomi Usui Kataoka, Jun Wada, Nobuo Kajitani and Hirofumi Makino
    Diabetes 2011 Jan; 60 (1): 189-199. https://doi.org/10.2337/db09-1894
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Islet Studies

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    Peroxisome-Generated Hydrogen Peroxide as Important Mediator of Lipotoxicity in Insulin-Producing Cells
    Matthias Elsner, Wiebke Gehrmann and Sigurd Lenzen
    Diabetes 2011 Jan; 60 (1): 200-208. https://doi.org/10.2337/db09-1401
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    Congenital Hyperinsulinism and Glucose Hypersensitivity in Homozygous and Heterozygous Carriers of Kir6.2 (KCNJ11) Mutation V290M MutationKATP Channel Inactivation Mechanism and Clinical Management
    Karen J. Loechner, Alejandro Akrouh, Harley T. Kurata, Carlo Dionisi-Vici, Arianna Maiorana, Milena Pizzoferro, Vittoria Rufini, Jean de Ville de Goyet, Carlo Colombo, Fabrizio Barbetti, Joseph C. Koster and Colin G. Nichols
    Diabetes 2011 Jan; 60 (1): 209-217. https://doi.org/10.2337/db10-0731
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    Exendin-4 Suppresses Src Activation and Reactive Oxygen Species Production in Diabetic Goto-Kakizaki Rat Islets in an Epac-Dependent Manner
    Eri Mukai, Shimpei Fujimoto, Hiroki Sato, Chitose Oneyama, Rieko Kominato, Yuichi Sato, Mayumi Sasaki, Yuichi Nishi, Masato Okada and Nobuya Inagaki
    Diabetes 2011 Jan; 60 (1): 218-226. https://doi.org/10.2337/db10-0021
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    β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency
    Safia Costes, Chang-jiang Huang, Tatyana Gurlo, Marie Daval, Aleksey V. Matveyenko, Robert A. Rizza, Alexandra E. Butler and Peter C. Butler
    Diabetes 2011 Jan; 60 (1): 227-238. https://doi.org/10.2337/db10-0522
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Immunology and Transplantation

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    Production of Functional Glucagon-Secreting α-Cells From Human Embryonic Stem Cells
    Alireza Rezania, Michael J. Riedel, Rhonda D. Wideman, Francis Karanu, Ziliang Ao, Garth L. Warnock and Timothy J. Kieffer
    Diabetes 2011 Jan; 60 (1): 239-247. https://doi.org/10.2337/db10-0573
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    Interleukin-1β Produced in Response to Islet Autoantigen Presentation Differentiates T-Helper 17 Cells at the Expense of Regulatory T-CellsImplications for the Timing of Tolerizing Immunotherapy
    Sebastien Bertin-Maghit, Dimeng Pang, Brendan O'Sullivan, Shannon Best, Emily Duggan, Sanjoy Paul, Helen Thomas, Thomas W.H. Kay, Leonard C. Harrison, Raymond Steptoe and Ranjeny Thomas
    Diabetes 2011 Jan; 60 (1): 248-257. https://doi.org/10.2337/db10-0104
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Pathophysiology

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    FTO Is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction
    Amélie Bravard, Etienne Lefai, Emmanuelle Meugnier, Sandra Pesenti, Emmanuel Disse, Julien Vouillarmet, Nöel Peretti, Rémi Rabasa-Lhoret, Martine Laville, Hubert Vidal and Jennifer Rieusset
    Diabetes 2011 Jan; 60 (1): 258-268. https://doi.org/10.2337/db10-0281
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    Coffee and Caffeine Consumption in Relation to Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women
    Atsushi Goto, Yiqing Song, Brian H. Chen, JoAnn E. Manson, Julie E. Buring and Simin Liu
    Diabetes 2011 Jan; 60 (1): 269-275. https://doi.org/10.2337/db10-1193
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    Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes
    Sami Oikarinen, Mika Martiskainen, Sisko Tauriainen, Heini Huhtala, Jorma Ilonen, Riitta Veijola, Olli Simell, Mikael Knip and Heikki Hyöty
    Diabetes 2011 Jan; 60 (1): 276-279. https://doi.org/10.2337/db10-0186
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Complications

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    miR-200a Prevents Renal Fibrogenesis Through Repression of TGF-β2 Expression
    Bo Wang, Philip Koh, Catherine Winbanks, Melinda T. Coughlan, Aaron McClelland, Anna Watson, Karin Jandeleit-Dahm, Wendy C. Burns, Merlin C. Thomas, Mark E. Cooper and Phillip Kantharidis
    Diabetes 2011 Jan; 60 (1): 280-287. https://doi.org/10.2337/db10-0892
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    Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats
    Eli Akude, Elena Zherebitskaya, Subir K. Roy Chowdhury, Darrell R. Smith, Rick T. Dobrowsky and Paul Fernyhough
    Diabetes 2011 Jan; 60 (1): 288-297. https://doi.org/10.2337/db10-0818
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    Glycated Hemoglobin and the Risk of Kidney Disease and Retinopathy in Adults With and Without Diabetes
    Elizabeth Selvin, Yang Ning, Michael W. Steffes, Lori D. Bash, Ronald Klein, Tien Y. Wong, Brad C. Astor, A. Richey Sharrett, Frederick L. Brancati and Josef Coresh
    Diabetes 2011 Jan; 60 (1): 298-305. https://doi.org/10.2337/db10-1198
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    Insulin Resistance, Defective Insulin-Mediated Fatty Acid Suppression, and Coronary Artery Calcification in Subjects With and Without Type 1 DiabetesThe CACTI Study
    Irene E. Schauer, Janet K. Snell-Bergeon, Bryan C. Bergman, David M. Maahs, Adam Kretowski, Robert H. Eckel and Marian Rewers
    Diabetes 2011 Jan; 60 (1): 306-314. https://doi.org/10.2337/db10-0328
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    High Connectivity Between Reduced Cortical Thickness and Disrupted White Matter Tracts in Long-Standing Type 1 Diabetes
    Daniel T. Franc, Christopher T. Kodl, Bryon A. Mueller, Ryan L. Muetzel, Kelvin O. Lim and Elizabeth R. Seaquist
    Diabetes 2011 Jan; 60 (1): 315-319. https://doi.org/10.2337/db10-0598
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Genetics

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    Targeted Inactivation of Kinesin-1 in Pancreatic β-Cells In Vivo Leads to Insulin Secretory Deficiency
    Ju Cui, Zai Wang, Qianni Cheng, Raozhou Lin, Xin-Mei Zhang, Po Sing Leung, Neal G. Copeland, Nancy A. Jenkins, Kwok-Ming Yao and Jian-Dong Huang
    Diabetes 2011 Jan; 60 (1): 320-330. https://doi.org/10.2337/db09-1078
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    Association of a Fasting Glucose Genetic Risk Score With Subclinical AtherosclerosisThe Atherosclerosis Risk in Communities (ARIC) Study
    Laura J. Rasmussen-Torvik, Man Li, Wen H. Kao, David Couper, Eric Boerwinkle, Suzette J. Bielinski, Aaron R. Folsom and James S. Pankow
    Diabetes 2011 Jan; 60 (1): 331-335. https://doi.org/10.2337/db10-0839
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    Both Polymorphic Variable Number of Tandem Repeats and Autoimmune Regulator Modulate Differential Expression of Insulin in Human Thymic Epithelial Cells
    Chuan Qi Cai, Tao Zhang, Mary B. Breslin, Matthieu Giraud and Michael S. Lan
    Diabetes 2011 Jan; 60 (1): 336-344. https://doi.org/10.2337/db10-0255
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    Genetic Predisposition to Long-Term Nondiabetic Deteriorations in Glucose HomeostasisTen-Year Follow-Up of the GLACIER Study
    Frida Renström, Dmitry Shungin, Ingegerd Johansson, the MAGIC Investigators, Jose C. Florez, Göran Hallmans, Frank B. Hu and Paul W. Franks
    Diabetes 2011 Jan; 60 (1): 345-354. https://doi.org/10.2337/db10-0933
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    mt-Nd2a Modifies Resistance Against Autoimmune Type 1 Diabetes in NOD Mice at the Level of the Pancreatic β-Cell
    Jing Chen, Aaron M. Gusdon, Jon Piganelli, Edward H. Leiter and Clayton E. Mathews
    Diabetes 2011 Jan; 60 (1): 355-359. https://doi.org/10.2337/db10-1241
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Erratum

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    Erratum
    Diabetes 2011 Jan; 60 (1): 360. https://doi.org/10.2337/db11-er01
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Online Letters to the Editor

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    Comment on: Kim et al. (2010) Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight. Diabetes;59:2772–2780
    Michael Wilkinson, Russell E. Brown, Syed A. Imran and Ehud Ur
    Diabetes 2011 Jan; 60 (1): e1. https://doi.org/10.2337/db10-1348
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    Response to Comment on: Kim et al. (2010) Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight. Diabetes;59:2772–2780
    Min Seon Kim
    Diabetes 2011 Jan; 60 (1): e2. https://doi.org/10.2337/db10-1457
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    Comment on: Kaiyala et al. (2010) Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice. Diabetes;59:1657–1666
    Paul S. MacLean
    Diabetes 2011 Jan; 60 (1): e3. https://doi.org/10.2337/db10-1343
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    Response to Comment on: Kaiyala et al. (2010) Identification of Body Fat Mass as a Major Determinant of Metabolic Rate in Mice. Diabetes;59:1657–1666
    Karl J. Kaiyala, Gregory J. Morton, Brian G. Leroux, Kayoko Ogimoto, Brent Wisse and Michael W. Schwartz
    Diabetes 2011 Jan; 60 (1): e4. https://doi.org/10.2337/db10-1445
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    Comment on: Matsushita et al. (2010) The Association of Hemoglobin A1c With Incident Heart Failure Among People Without Diabetes: The Atherosclerosis Risk in Communities Study. Diabetes;59:2020–2026
    Eiji Oda
    Diabetes 2011 Jan; 60 (1): e5. https://doi.org/10.2337/db10-1381
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    Response to Comment on: Matsushita et al. (2010) The Association of Hemoglobin A1c With Incident Heart Failure Among People Without Diabetes: The Atherosclerosis Risk in Communities Study. Diabetes;59:2020–2026
    Kunihiro Matsushita and Elizabeth Selvin
    Diabetes 2011 Jan; 60 (1): e6. https://doi.org/10.2337/db10-1474
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    Comment on: Lin et al. (2010) Immune Cell–Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetes;59: 2247–2252
    Jakob Appel Østergaard, Steffen Thiel, Troels Krarup Hansen, Ruth Rasch and Allan Flyvbjerg
    Diabetes 2011 Jan; 60 (1): e7-e8. https://doi.org/10.2337/db10-1298
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    Response to Comment on: Lin et al. (2010) Immune Cell–Derived C3 Is Required for Autoimmune Diabetes Induced by Multiple Low Doses of Streptozotocin. Diabetes;59:2247–2252
    Marvin Lin, Barbara Murphy, M. Edward Medof, Stephan Segerer, Peter S. Heeger and Bernd Schröppel
    Diabetes 2011 Jan; 60 (1): e9. https://doi.org/10.2337/db10-1396
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January 2011, 60(1)
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  • Perspectives in Diabetes
  • Commentaries
  • Metabolism
  • Signal Transduction
  • Obesity Studies
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  • Immunology and Transplantation
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  • Genetics
  • Erratum
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  • Poverty and Obesity in the U.S.
  • Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
  • Latent Autoimmune Diabetes in Adults
  • Managing Hyperglycemia in the COVID-19 Inflammatory Storm
  • Management of Latent Autoimmune Diabetes in Adults: A Consensus Statement From an International Expert Panel
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