Diabetes: 60 (2)

February 01 2011; volume 60 issue 2

Editorial

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It's Time to Consider Changing the RulesThe Rationale for Rethinking Control Groups in Clinical Trials Aimed at Reversing Type 1 Diabetes
Mark A. Atkinson

Diabetes 2011 Feb; 60 (2): 361-363. https://doi.org/10.2337/db10-1506

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Perspectives in Diabetes

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Historical Perspective: Beginnings of the β-CellCurrent Perspectives in β-Cell Development
Philip A. Seymour and Maike Sander

Diabetes 2011 Feb; 60 (2): 364-376. https://doi.org/10.2337/db10-1068

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Commentaries

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Glucagon as a Critical Factor in the Pathology of Diabetes
Dale S. Edgerton and Alan D. Cherrington

Diabetes 2011 Feb; 60 (2): 377-380. https://doi.org/10.2337/db10-1594

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A Therapeutic Insight in β-Cell Imaging?
Martin Gotthardt

Diabetes 2011 Feb; 60 (2): 381-382. https://doi.org/10.2337/db10-1591

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Metabolism

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Effects of Acute Hyperglucagonemia on Hepatic and Intestinal Lipoprotein Production and Clearance in Healthy Humans
Changting Xiao, Mirjana Pavlic, Linda Szeto, Bruce W. Patterson and Gary F. Lewis

Diabetes 2011 Feb; 60 (2): 383-390. https://doi.org/10.2337/db10-0763

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Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice
Young Lee, May-Yun Wang, Xiu Quan Du, Maureen J. Charron and Roger H. Unger

Diabetes 2011 Feb; 60 (2): 391-397. https://doi.org/10.2337/db10-0426

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Hepatic Glycogen Supercompensation Activates AMP-Activated Protein Kinase, Impairs Insulin Signaling, and Reduces Glycogen Deposition in the Liver
Jason J. Winnick, Zhibo An, Christopher J. Ramnanan, Marta Smith, Jose M. Irimia, Doss W. Neal, Mary Courtney Moore, Peter J. Roach and Alan D. Cherrington

Diabetes 2011 Feb; 60 (2): 398-407. https://doi.org/10.2337/db10-0592

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Normal Postprandial Nonesterified Fatty Acid Uptake in Muscles Despite Increased Circulating Fatty Acids in Type 2 Diabetes
Sébastien M. Labbé, Etienne Croteau, Thomas Grenier-Larouche, Frédérique Frisch, René Ouellet, Réjean Langlois, Brigitte Guérin, Eric E. Turcotte and André C. Carpentier

Diabetes 2011 Feb; 60 (2): 408-415. https://doi.org/10.2337/db10-0997

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Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin α₂β₁ in Mice
Li Kang, Julio E. Ayala, Robert S. Lee-Young, Zhonghua Zhang, Freyja D. James, P. Darrell Neufer, Ambra Pozzi, Mary M. Zutter and David H. Wasserman

Diabetes 2011 Feb; 60 (2): 416-426. https://doi.org/10.2337/db10-1116

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The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function
Martin E. Lidell, Erin L. Seifert, Rickard Westergren, Mikael Heglind, Adrienne Gowing, Valentina Sukonina, Zahra Arani, Paula Itkonen, Simonetta Wallin, Fredrik Westberg, Julia Fernandez-Rodriguez, Markku Laakso, Tommy Nilsson, Xiao-Rong Peng, Mary-Ellen Harper and Sven Enerbäck

Diabetes 2011 Feb; 60 (2): 427-435. https://doi.org/10.2337/db10-0409

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Participation of Hindbrain AMP-Activated Protein Kinase in Glucoprivic Feeding
Ai-Jun Li, Qing Wang and Sue Ritter

Diabetes 2011 Feb; 60 (2): 436-442. https://doi.org/10.2337/db10-0352

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Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance
Jussi Hirvonen, Kirsi A. Virtanen, Lauri Nummenmaa, Jarna C. Hannukainen, Miikka-Juhani Honka, Marco Bucci, Sergey V. Nesterov, Riitta Parkkola, Juha Rinne, Patricia Iozzo and Pirjo Nuutila

Diabetes 2011 Feb; 60 (2): 443-447. https://doi.org/10.2337/db10-0940

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Distinct Roles of Endothelial and Adipocyte Caveolin-1 in Macrophage Infiltration and Adipose Tissue Metabolic Activity
Nolwenn Briand, Soazig Le Lay, William C. Sessa, Pascal Ferré and Isabelle Dugail

Diabetes 2011 Feb; 60 (2): 448-453. https://doi.org/10.2337/db10-0856

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Signal Transduction

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Phosphatidylinositol-4-Phosphate-5-Kinase α Deficiency Alters Dynamics of Glucose-Stimulated Insulin Release to Improve Glucohomeostasis and Decrease Obesity in Mice
Ping Huang, Oladapo Yeku, Haihong Zong, Phyllis Tsang, Wenjuan Su, Xiao Yu, Shuzhi Teng, Mary Osisami, Yasunori Kanaho, Jeffrey E. Pessin and Michael A. Frohman

Diabetes 2011 Feb; 60 (2): 454-463. https://doi.org/10.2337/db10-0614

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Obesity Studies

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Smad3 Deficiency in Mice Protects Against Insulin Resistance and Obesity Induced by a High-Fat Diet
Chek Kun Tan, Nicolas Leuenberger, Ming Jie Tan, Yew Wai Yan, Yinghui Chen, Ravi Kambadur, Walter Wahli and Nguan Soon Tan

Diabetes 2011 Feb; 60 (2): 464-476. https://doi.org/10.2337/db10-0801

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Effects of Metformin on Body Weight and Body Composition in Obese Insulin-Resistant ChildrenA Randomized Clinical Trial
Jack A. Yanovski, Jonathan Krakoff, Christine G. Salaita, Jennifer R. McDuffie, Merel Kozlosky, Nancy G. Sebring, James C. Reynolds, Sheila M. Brady and Karim A. Calis

Diabetes 2011 Feb; 60 (2): 477-485. https://doi.org/10.2337/db10-1185

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Selective Inactivation of c-Jun NH₂-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice
Xinmei Zhang, Aimin Xu, Sookja K. Chung, Justin H.B. Cresser, Gary Sweeney, Rachel L.C. Wong, Anning Lin and Karen S.L. Lam

Diabetes 2011 Feb; 60 (2): 486-495. https://doi.org/10.2337/db10-0650

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A Newly Identified CG301269 Improves Lipid and Glucose Metabolism Without Body Weight Gain Through Activation of Peroxisome Proliferator–Activated Receptor α and γ
Hyun Woo Jeong, Joo-Won Lee, Woo Sik Kim, Sung Sik Choe, Kyung-Hee Kim, Ho Seon Park, Hyun Jung Shin, Gha Young Lee, Dongkyu Shin, Hanjae Lee, Jun Hee Lee, Eun Bok Choi, Hyeon Kyu Lee, Heekyoung Chung, Seung Bum Park, Kyong Soo Park, Hyo-Soo Kim, Seonggu Ro and Jae Bum Kim

Diabetes 2011 Feb; 60 (2): 496-506. https://doi.org/10.2337/db09-1145

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Hypoxia-Induced Intrauterine Growth Restriction Increases the Susceptibility of Rats to High-Fat Diet–Induced Metabolic Syndrome
Christian F. Rueda-Clausen, Vernon W. Dolinsky, Jude S. Morton, Spencer D. Proctor, Jason R.B. Dyck and Sandra T. Davidge

Diabetes 2011 Feb; 60 (2): 507-516. https://doi.org/10.2337/db10-1239

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Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue
Tim B. Koenen, Rinke Stienstra, Lambertus J. van Tits, Jacqueline de Graaf, Anton F.H. Stalenhoef, Leo A.B. Joosten, Cees J. Tack and Mihai G. Netea

Diabetes 2011 Feb; 60 (2): 517-524. https://doi.org/10.2337/db10-0266

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Islet Studies

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Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes
Jose Mellado-Gil, Taylor C. Rosa, Cem Demirci, Jose A. Gonzalez-Pertusa, Silvia Velazquez-Garcia, Sara Ernst, Shelley Valle, Rupangi C. Vasavada, Andrew F. Stewart, Laura C. Alonso and Adolfo Garcia-Ocaña

Diabetes 2011 Feb; 60 (2): 525-536. https://doi.org/10.2337/db09-1305

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Interleukin-6 Enhances Glucose-Stimulated Insulin Secretion From Pancreatic β-CellsPotential Involvement of the PLC-IP₃–Dependent Pathway
Toshinobu Suzuki, Junta Imai, Tetsuya Yamada, Yasushi Ishigaki, Keizo Kaneko, Kenji Uno, Yutaka Hasegawa, Hisamitsu Ishihara, Yoshitomo Oka and Hideki Katagiri

Diabetes 2011 Feb; 60 (2): 537-547. https://doi.org/10.2337/db10-0796

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The Expression and Function of Glucose-Dependent Insulinotropic Polypeptide in the Embryonic Mouse Pancreas
Krishna Prasadan, Masayuki Koizumi, Sidhartha Tulachan, Chiyo Shiota, Nikesh Lath, Jose Paredes, Ping Guo, Yousef El-Gohary, Marcus Malek, Sohail Shah and George K. Gittes

Diabetes 2011 Feb; 60 (2): 548-554. https://doi.org/10.2337/db09-0035

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Immunology and Transplantation

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Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice
Jeremy Racine, Miao Wang, Chunyan Zhang, Chia-Lei Lin, Hongjun Liu, Ivan Todorov, Mark Atkinson and Defu Zeng

Diabetes 2011 Feb; 60 (2): 555-564. https://doi.org/10.2337/db10-0827

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Combined Small Interfering RNA Therapy and In Vivo Magnetic Resonance Imaging in Islet Transplantation
Ping Wang, Mehmet V. Yigit, Zdravka Medarova, Lingling Wei, Guangping Dai, Christian Schuetz and Anna Moore

Diabetes 2011 Feb; 60 (2): 565-571. https://doi.org/10.2337/db10-1400

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Pathophysiology

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Reduction in Basal Nitric Oxide Activity Causes Albuminuria
Christian Ott, Markus P. Schneider, Christian Delles, Markus P. Schlaich and Roland E. Schmieder

Diabetes 2011 Feb; 60 (2): 572-576. https://doi.org/10.2337/db09-1630

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Thirty Years of Prospective Nationwide Incidence of Childhood Type 1 DiabetesThe Accelerating Increase by Time Tends to Level Off in Sweden
Yonas Berhan, Ingeborg Waernbaum, Torbjörn Lind, Anna Möllsten, Gisela Dahlquist and for the Swedish Childhood Diabetes Study Group*

Diabetes 2011 Feb; 60 (2): 577-581. https://doi.org/10.2337/db10-0813

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Complications

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Levels of Oxidized LDL and Advanced Glycation End Products–Modified LDL in Circulating Immune Complexes Are Strongly Associated With Increased Levels of Carotid Intima-Media Thickness and Its Progression in Type 1 Diabetes
Maria F. Lopes-Virella, Kelly J. Hunt, Nathaniel L. Baker, John Lachin, David M. Nathan, G. Virella and the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group

Diabetes 2011 Feb; 60 (2): 582-589. https://doi.org/10.2337/db10-0915

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The Protective Role of Smad7 in Diabetic Kidney Disease: Mechanism and Therapeutic Potential
Hai Yong Chen, Xiao R. Huang, Wansheng Wang, Jin Hua Li, Rainer L. Heuchel, Arthur C.K. Chung and Hui Yao Lan

Diabetes 2011 Feb; 60 (2): 590-601. https://doi.org/10.2337/db10-0403

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Adrenergic Mediation of Hypoglycemia-Associated Autonomic Failure
Ranjani Ramanathan and Philip E. Cryer

Diabetes 2011 Feb; 60 (2): 602-606. https://doi.org/10.2337/db10-1374

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Progression of Carotid Artery Intima-Media Thickness During 12 Years in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study
Joseph F. Polak, Jye-Yu C. Backlund, Patricia A. Cleary, Anita P. Harrington, Daniel H. O’Leary, John M. Lachin, David M. Nathan and for the DCCT/EDIC Research Group

Diabetes 2011 Feb; 60 (2): 607-613. https://doi.org/10.2337/db10-0296

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Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic RetinopathyImplications in Retinal Neovascularization
Mohamed Al-Shabrawey, Rene Mussell, Khalid Kahook, Amany Tawfik, Mohamed Eladl, Vijay Sarthy, Julian Nussbaum, Ahmed El-Marakby, Sun Young Park, Zafer Gurel, Nader Sheibani and Krishna Rao Maddipati

Diabetes 2011 Feb; 60 (2): 614-624. https://doi.org/10.2337/db10-0008

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Diabetic Downregulation of Nrf2 Activity via ERK Contributes to Oxidative Stress–Induced Insulin Resistance in Cardiac Cells In Vitro and In Vivo
Yi Tan, Tomonaga Ichikawa, Jinqing Li, Qiusheng Si, Huaitao Yang, Xiangbai Chen, Curtis S. Goldblatt, Colin J. Meyer, Xiaokun Li, Lu Cai and Taixing Cui

Diabetes 2011 Feb; 60 (2): 625-633. https://doi.org/10.2337/db10-1164

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Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway
Munehiro Kitada, Shinji Kume, Noriko Imaizumi and Daisuke Koya

Diabetes 2011 Feb; 60 (2): 634-643. https://doi.org/10.2337/db10-0386

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Pharmacology and Therapeutics

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Selective Reversible Inhibition of Liver Carnitine Palmitoyl-Transferase 1 by Teglicar Reduces Gluconeogenesis and Improves Glucose Homeostasis
Roberto Conti, Edoardo Mannucci, Pompeo Pessotto, Emanuela Tassoni, Paolo Carminati, Fabio Giannessi and Arduino Arduini

Diabetes 2011 Feb; 60 (2): 644-651. https://doi.org/10.2337/db10-0346

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Adiponectin Pretreatment Counteracts the Detrimental Effect of a Diabetic Environment on Endothelial Progenitors
Simon F. Leicht, Theresa M. Schwarz, Patrick C. Hermann, Jochen Seissler, Alexandra Aicher and Christopher Heeschen

Diabetes 2011 Feb; 60 (2): 652-661. https://doi.org/10.2337/db10-0240

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Genetics

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Resequencing and Analysis of Variation in the TCF7L2 Gene in African Americans Suggests That SNP rs7903146 Is the Causal Diabetes Susceptibility Variant
Nicholette D. Palmer, Jessica M. Hester, S. Sandy An, Adebowale Adeyemo, Charles Rotimi, Carl D. Langefeld, Barry I. Freedman, Maggie C.Y. Ng and Donald W. Bowden

Diabetes 2011 Feb; 60 (2): 662-668. https://doi.org/10.2337/db10-0134

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Links Between Insulin Resistance, Adenosine A_2B Receptors, and Inflammatory Markers in Mice and Humans
Robert A. Figler, Guoquan Wang, Susseela Srinivasan, Dae Young Jung, Zhiyou Zhang, James S. Pankow, Katya Ravid, Bertil Fredholm, Catherine C. Hedrick, Stephen S. Rich, Jason K. Kim, Kathryn F. LaNoue and Joel Linden

Diabetes 2011 Feb; 60 (2): 669-679. https://doi.org/10.2337/db10-1070

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The Same Chromosome 9p21.3 Locus Is Associated With Type 2 Diabetes and Coronary Artery Disease in a Chinese Han Population
Xiang Cheng, Lisong Shi, Shaofang Nie, Fan Wang, Xiuchun Li, Chengqi Xu, Pengyun Wang, Baofeng Yang, Qingxian Li, Zhenwei Pan, Yue Li, Hao Xia, Chenhong Zheng, Yuhe Ke, Yanxia Wu, Tingting Tang, Xinxin Yan, Yan Yang, Ni Xia, Rui Yao, Binbin Wang, Xu Ma, Qiutang Zeng, Xin Tu, Yuhua Liao and Qing K. Wang

Diabetes 2011 Feb; 60 (2): 680-684. https://doi.org/10.2337/db10-0185

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An Interferon-Induced Helicase (IFIH1) Gene Polymorphism Associates With Different Rates of Progression From Autoimmunity to Type 1 Diabetes
Christiane Winkler, Claudia Lauber, Kerstin Adler, Harald Grallert, Thomas Illig, Anette-Gabriele Ziegler and Ezio Bonifacio

Diabetes 2011 Feb; 60 (2): 685-690. https://doi.org/10.2337/db10-1269

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Erratum

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Errata
Diabetes 2011 Feb; 60 (2): 691. https://doi.org/10.2337/db11-er02

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Issues and Events

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Issues and Events
Diabetes 2011 Feb; 60 (2): 692. https://doi.org/10.2337/db11-ie02

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Online Letters to the Editor

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Comment on: Soranzo et al. Common Variants at 10 Genomic Loci Influence Hemoglobin A_1C Levels via Glycemic and Nonglycemic Pathways. Diabetes 2010;59:3229–3239
Rosa Corcoy

Diabetes 2011 Feb; 60 (2): e10. https://doi.org/10.2337/db10-1368

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Response to Comment on: Soranzo et al. Common Variants at 10 Genomic Loci Influence Hemoglobin A_1C Levels via Glycemic and Nonglycemic Pathways. Diabetes 2010;59:3229–3239
James B. Meigs, Nicole Soranzo and the rest of the MAGIC HbA1c GWAS co-authors

Diabetes 2011 Feb; 60 (2): e11. https://doi.org/10.2337/db10-1692

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Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862–2871
Francesco Vendrame and Francesco Dotta

Diabetes 2011 Feb; 60 (2): e12. https://doi.org/10.2337/db10-1489

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Response to Comment on: Meagher et al. Neutralization of Interleukin-16 Protects Nonobese Diabetic Mice From Autoimmune Type 1 Diabetes by a CCL4-Dependent Mechanism. Diabetes 2010;59:2862–2871
Craig Meagher, William Cruikshank and Terry L. Delovitch

Diabetes 2011 Feb; 60 (2): e13. https://doi.org/10.2337/db10-1620

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Table of Contents

Editorial

Perspectives in Diabetes

Commentaries

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics

Erratum

Issues and Events

Online Letters to the Editor

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