Diabetes: 61 (11)

November 01 2012; volume 61 issue 11

Commentaries

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Understanding the Elusive Mechanism of Action of TCF7L2 in Metabolism
Struan F.A. Grant

Diabetes 2012 Nov; 61 (11): 2657-2658. https://doi.org/10.2337/db12-0891

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Seeing Is Believing: Dietary Fatty Acids Hurry Up From the Stomach to the Heart of Patients With Impaired Glucose Tolerance
Patricia Iozzo

Diabetes 2012 Nov; 61 (11): 2659-2660. https://doi.org/10.2337/db12-0803

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Methodology Reviews

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Muscle PerfusionIts Measurement and Role in Metabolic Regulation
Eugene J. Barrett and Stephen Rattigan

Diabetes 2012 Nov; 61 (11): 2661-2668. https://doi.org/10.2337/db12-0271

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³¹P-Magnetization Transfer Magnetic Resonance Spectroscopy Measurements of In Vivo Metabolism
Douglas E. Befroy, Douglas L. Rothman, Kitt Falk Petersen and Gerald I. Shulman

Diabetes 2012 Nov; 61 (11): 2669-2678. https://doi.org/10.2337/db12-0558

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Metabolism

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Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels
Madeleen Bosma, Matthijs K.C. Hesselink, Lauren M. Sparks, Silvie Timmers, Maria João Ferraz, Frits Mattijssen, Denis van Beurden, Gert Schaart, Marc H. de Baets, Fons K. Verheyen, Sander Kersten and Patrick Schrauwen

Diabetes 2012 Nov; 61 (11): 2679-2690. https://doi.org/10.2337/db11-1402

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Diurnal Pattern to Insulin Secretion and Insulin Action in Healthy Individuals
Ahmed Saad, Chiara Dalla Man, Debashis K. Nandy, James A. Levine, Adil E. Bharucha, Robert A. Rizza, Rita Basu, Rickey E. Carter, Claudio Cobelli, Yogish C. Kudva and Ananda Basu

Diabetes 2012 Nov; 61 (11): 2691-2700. https://doi.org/10.2337/db11-1478

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Increased Myocardial Uptake of Dietary Fatty Acids Linked to Cardiac Dysfunction in Glucose-Intolerant Humans
Sébastien M. Labbé, Thomas Grenier-Larouche, Christophe Noll, Serge Phoenix, Brigitte Guérin, Eric E. Turcotte and André C. Carpentier

Diabetes 2012 Nov; 61 (11): 2701-2710. https://doi.org/10.2337/db11-1805

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Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly
Clare Flannery, Sylvie Dufour, Rasmus Rabøl, Gerald I. Shulman and Kitt Falk Petersen

Diabetes 2012 Nov; 61 (11): 2711-2717. https://doi.org/10.2337/db12-0206

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Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages
Jeb S. Orr, Michael J. Puglisi, Kate L.J. Ellacott, Carey N. Lumeng, David H. Wasserman and Alyssa H. Hasty

Diabetes 2012 Nov; 61 (11): 2718-2727. https://doi.org/10.2337/db11-1595

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Effect of Glycemia on Plasma Incretins and the Incretin Effect During Oral Glucose Tolerance Test
Marzieh Salehi, Benedict Aulinger and David A. D’Alessio

Diabetes 2012 Nov; 61 (11): 2728-2733. https://doi.org/10.2337/db11-1825

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Caloric Restriction Chronically Impairs Metabolic Programming in Mice
Henriette Kirchner, Susanna M. Hofmann, Antje Fischer-Rosinský, Jazzminn Hembree, William Abplanalp, Nickki Ottaway, Elizabeth Donelan, Radha Krishna, Stephen C. Woods, Timo D. Müller, Joachim Spranger, Diego Perez-Tilve, Paul T. Pfluger, Matthias H. Tschöp and Kirk M. Habegger

Diabetes 2012 Nov; 61 (11): 2734-2742. https://doi.org/10.2337/db11-1621

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Exercise Alleviates Lipid-Induced Insulin Resistance in Human Skeletal Muscle–Signaling Interaction at the Level of TBC1 Domain Family Member 4
Christian Pehmøller, Nina Brandt, Jesper B. Birk, Louise D. Høeg, Kim A. Sjøberg, Laurie J. Goodyear, Bente Kiens, Erik A. Richter and Jørgen F.P. Wojtaszewski

Diabetes 2012 Nov; 61 (11): 2743-2752. https://doi.org/10.2337/db11-1572

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Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling
Sarah H. Lockie, Kristy M. Heppner, Nilika Chaudhary, Joseph R. Chabenne, Donald A. Morgan, Christelle Veyrat-Durebex, Gayathri Ananthakrishnan, Françoise Rohner-Jeanrenaud, Daniel J. Drucker, Richard DiMarchi, Kamal Rahmouni, Brian J. Oldfield, Matthias H. Tschöp and Diego Perez-Tilve

Diabetes 2012 Nov; 61 (11): 2753-2762. https://doi.org/10.2337/db11-1556

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Signal Transduction

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Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress–Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis
Daniel A. Cunha, Mariana Igoillo-Esteve, Esteban N. Gurzov, Carla M. Germano, Najib Naamane, Ihsane Marhfour, Makiko Fukaya, Jean-Marie Vanderwinden, Conny Gysemans, Chantal Mathieu, Lorella Marselli, Piero Marchetti, Heather P. Harding, David Ron, Décio L. Eizirik and Miriam Cnop

Diabetes 2012 Nov; 61 (11): 2763-2775. https://doi.org/10.2337/db12-0123

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Obesity Studies

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Fat-Specific DsbA-L Overexpression Promotes Adiponectin Multimerization and Protects Mice From Diet-Induced Obesity and Insulin Resistance
Meilian Liu, Ruihua Xiang, Sarah Ann Wilk, Ning Zhang, Lauren B. Sloane, Kian Azarnoush, Lijun Zhou, Hongzhi Chen, Guangda Xiang, Christi A. Walter, Steven N. Austad, Nicolas Musi, Ralph A. DeFronzo, Reto Asmis, Philipp E. Scherer, Lily Q. Dong and Feng Liu

Diabetes 2012 Nov; 61 (11): 2776-2786. https://doi.org/10.2337/db12-0169

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Effects of Aerobic Versus Resistance Exercise Without Caloric Restriction on Abdominal Fat, Intrahepatic Lipid, and Insulin Sensitivity in Obese Adolescent BoysA Randomized, Controlled Trial
SoJung Lee, Fida Bacha, Tamara Hannon, Jennifer L. Kuk, Chris Boesch and Silva Arslanian

Diabetes 2012 Nov; 61 (11): 2787-2795. https://doi.org/10.2337/db12-0214

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Depressed Levels of Prostaglandin F_2α in Mice Lacking Akr1b7 Increase Basal Adiposity and Predispose to Diet-Induced Obesity
Fanny E. Volat, Jean-Christophe Pointud, Emilie Pastel, Béatrice Morio, Benoit Sion, Ghislaine Hamard, Michel Guichardant, Romain Colas, Anne-Marie Lefrançois-Martinez and Antoine Martinez

Diabetes 2012 Nov; 61 (11): 2796-2806. https://doi.org/10.2337/db11-1297

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Adipose Tissue TCF7L2 Splicing Is Regulated by Weight Loss and Associates With Glucose and Fatty Acid Metabolism
Dorota Kaminska, Tiina Kuulasmaa, Sari Venesmaa, Pirjo Käkelä, Maija Vaittinen, Leena Pulkkinen, Matti Pääkkönen, Helena Gylling, Markku Laakso and Jussi Pihlajamäki

Diabetes 2012 Nov; 61 (11): 2807-2813. https://doi.org/10.2337/db12-0239

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Membrane-Tethered Delta-Like 1 Homolog (DLK1) Restricts Adipose Tissue Size by Inhibiting Preadipocyte Proliferation
Sussi B. Mortensen, Charlotte H. Jensen, Mikael Schneider, Mads Thomassen, Torben A. Kruse, Jorge Laborda, Søren P. Sheikh and Ditte C. Andersen

Diabetes 2012 Nov; 61 (11): 2814-2822. https://doi.org/10.2337/db12-0176

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Vaspin Is an Adipokine Ameliorating ER Stress in Obesity as a Ligand for Cell-Surface GRP78/MTJ-1 Complex
Atsuko Nakatsuka, Jun Wada, Izumi Iseda, Sanae Teshigawara, Kanji Higashio, Kazutoshi Murakami, Motoko Kanzaki, Kentaro Inoue, Takahiro Terami, Akihiro Katayama, Kazuyuki Hida, Jun Eguchi, Chikage Sato Horiguchi, Daisuke Ogawa, Yasushi Matsuki, Ryuji Hiramatsu, Hideo Yagita, Shigeru Kakuta, Yoichiro Iwakura and Hirofumi Makino

Diabetes 2012 Nov; 61 (11): 2823-2832. https://doi.org/10.2337/db12-0232

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Maternal High-Fat Diet During Gestation or Suckling Differentially Affects Offspring Leptin Sensitivity and Obesity
Bo Sun, Ryan H. Purcell, Chantelle E. Terrillion, Jianqun Yan, Timothy H. Moran and Kellie L.K. Tamashiro

Diabetes 2012 Nov; 61 (11): 2833-2841. https://doi.org/10.2337/db11-0957

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Islet Studies

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NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion
Ning Li, Bin Li, Thierry Brun, Christine Deffert-Delbouille, Zahia Mahiout, Youssef Daali, Xiao-Juan Ma, Karl-Heinz Krause and Pierre Maechler

Diabetes 2012 Nov; 61 (11): 2842-2850. https://doi.org/10.2337/db12-0009

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Vascular Endothelial Growth Factor–Mediated Islet Hypervascularization and Inflammation Contribute to Progressive Reduction of β-Cell Mass
Judith Agudo, Eduard Ayuso, Veronica Jimenez, Alba Casellas, Cristina Mallol, Ariana Salavert, Sabrina Tafuro, Mercè Obach, Albert Ruzo, Marta Moya, Anna Pujol and Fatima Bosch

Diabetes 2012 Nov; 61 (11): 2851-2861. https://doi.org/10.2337/db12-0134

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Immunology and Transplantation

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Cytotoxic Mechanisms Employed by Mouse T Cells to Destroy Pancreatic β-Cells
Vineeth Varanasi, Lia Avanesyan, Desiree M. Schumann and Alexander V. Chervonsky

Diabetes 2012 Nov; 61 (11): 2862-2870. https://doi.org/10.2337/db11-1784

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Long-Term Remission of Diabetes in NOD Mice Is Induced by Nondepleting Anti-CD4 and Anti-CD8 Antibodies
Zuoan Yi, Ramiro Diz, Aaron J. Martin, Yves Maurice Morillon, Douglas E. Kline, Li Li, Bo Wang and Roland Tisch

Diabetes 2012 Nov; 61 (11): 2871-2880. https://doi.org/10.2337/db12-0098

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Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice
Roham Parsa, Pernilla Andresen, Alan Gillett, Sohel Mia, Xing-Mei Zhang, Sofia Mayans, Dan Holmberg and Robert A. Harris

Diabetes 2012 Nov; 61 (11): 2881-2892. https://doi.org/10.2337/db11-1635

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B-Cell Cross-Presentation of Autologous Antigen Precipitates Diabetes
Eliana Mariño, Bernice Tan, Lauren Binge, Charles R. Mackay and Shane T. Grey

Diabetes 2012 Nov; 61 (11): 2893-2905. https://doi.org/10.2337/db12-0006

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Pathophysiology

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The Role of MicroRNA-146a in the Pathogenesis of the Diabetic Wound-Healing ImpairmentCorrection With Mesenchymal Stem Cell Treatment
Junwang Xu, Wenjie Wu, Liping Zhang, Wanda Dorset-Martin, Michael W. Morris, Marc E. Mitchell and Kenneth W. Liechty

Diabetes 2012 Nov; 61 (11): 2906-2912. https://doi.org/10.2337/db12-0145

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High Glucose Inhibits the Aspirin-Induced Activation of the Nitric Oxide/cGMP/cGMP-Dependent Protein Kinase Pathway and Does Not Affect the Aspirin-Induced Inhibition of Thromboxane Synthesis in Human Platelets
Isabella Russo, Michela Viretto, Cristina Barale, Luigi Mattiello, Gabriella Doronzo, Andrea Pagliarino, Franco Cavalot, Mariella Trovati and Giovanni Anfossi

Diabetes 2012 Nov; 61 (11): 2913-2921. https://doi.org/10.2337/db12-0040

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Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations
Angela R. Subauste, Arun K. Das, Xiangquan Li, Brandon Elliot, Charles Evans, Mahmoud El Azzouny, Mary Treutelaar, Elif Oral, Todd Leff and Charles F. Burant

Diabetes 2012 Nov; 61 (11): 2922-2931. https://doi.org/10.2337/db12-0004

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C1q/TNF-Related Protein-3 (CTRP-3) and Pigment Epithelium-Derived Factor (PEDF) Concentrations in Patients With Type 2 Diabetes and Metabolic Syndrome
Kyung Mook Choi, Soon Young Hwang, Ho Cheol Hong, Sae Jeong Yang, Hae Yoon Choi, Hye Jin Yoo, Kwan Woo Lee, Moon Suk Nam, Yong Soo Park, Jeong Taek Woo, Young Seol Kim, Dong Seop Choi, Byung-Soo Youn and Sei Hyun Baik

Diabetes 2012 Nov; 61 (11): 2932-2936. https://doi.org/10.2337/db12-0217

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Complications

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Mechanisms Involved in the Development and Healing of Diabetic Foot Ulceration
Thanh Dinh, Francesco Tecilazich, Antonios Kafanas, John Doupis, Charalambos Gnardellis, Ermelindo Leal, Ana Tellechea, Leena Pradhan, Thomas E. Lyons, John M. Giurini and Aristidis Veves

Diabetes 2012 Nov; 61 (11): 2937-2947. https://doi.org/10.2337/db12-0227

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Therapeutic Potential of a Monoclonal Antibody Blocking the Wnt Pathway in Diabetic Retinopathy
Kyungwon Lee, Yang Hu, Lexi Ding, Ying Chen, Yusuke Takahashi, Robert Mott and Jian-xing Ma

Diabetes 2012 Nov; 61 (11): 2948-2957. https://doi.org/10.2337/db11-0300

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Vegfa Protects the Glomerular Microvasculature in Diabetes
Gavasker A. Sivaskandarajah, Marie Jeansson, Yoshiro Maezawa, Vera Eremina, Hans J. Baelde and Susan E. Quaggin

Diabetes 2012 Nov; 61 (11): 2958-2966. https://doi.org/10.2337/DB11-1655

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Protective Effects of GLP-1 on Glomerular Endothelium and Its Inhibition by PKCβ Activation in Diabetes
Akira Mima, Junko Hiraoka-Yamomoto, Qian Li, Munehiro Kitada, Chenzhong Li, Pedro Geraldes, Motonobu Matsumoto, Koji Mizutani, Kyoungmin Park, Christopher Cahill, Shin-Ichi Nishikawa, Christian Rask-Madsen and George L. King

Diabetes 2012 Nov; 61 (11): 2967-2979. https://doi.org/10.2337/db11-1824

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Increased Inner Ear Susceptibility to Noise Injury in Mice With Streptozotocin-Induced Diabetes
Takeshi Fujita, Daisuke Yamashita, Sayaka Katsunuma, Shingo Hasegawa, Hitoshi Tanimoto and Ken-ichi Nibu

Diabetes 2012 Nov; 61 (11): 2980-2986. https://doi.org/10.2337/db11-1845

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Improvements in the Life Expectancy of Type 1 DiabetesThe Pittsburgh Epidemiology of Diabetes Complications Study Cohort
Rachel G. Miller, Aaron M. Secrest, Ravi K. Sharma, Thomas J. Songer and Trevor J. Orchard

Diabetes 2012 Nov; 61 (11): 2987-2992. https://doi.org/10.2337/db11-1625

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Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes
Antonio Ceriello, Anna Novials, Emilio Ortega, Lucia La Sala, Gemma Pujadas, Roberto Testa, Anna Rita Bonfigli, Katherine Esposito and Dario Giugliano

Diabetes 2012 Nov; 61 (11): 2993-2997. https://doi.org/10.2337/db12-0224

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Genetics/Genomes/Proteomics/Metabolomics

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A Prospective Study of Leukocyte Telomere Length and Risk of Type 2 Diabetes in Postmenopausal Women
Nai-chieh Y. You, Brian H. Chen, Yiqing Song, XuYang Lu, Yilin Chen, JoAnn E. Manson, Mo Kang, Barbara V. Howard, Karen L. Margolis, J. David Curb, Lawrence S. Phillips, Marcia L. Stefanick, Lesley F. Tinker and Simin Liu

Diabetes 2012 Nov; 61 (11): 2998-3004. https://doi.org/10.2337/db12-0241

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FTO Genotype and 2-Year Change in Body Composition and Fat Distribution in Response to Weight-Loss DietsThe POUNDS LOST Trial
Xiaomin Zhang, Qibin Qi, Cuilin Zhang, Steven R. Smith, Frank B. Hu, Frank M. Sacks, George A. Bray and Lu Qi

Diabetes 2012 Nov; 61 (11): 3005-3011. https://doi.org/10.2337/db11-1799

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Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes
Joanna M.M. Howson, Jason D. Cooper, Deborah J. Smyth, Neil M. Walker, Helen Stevens, Jin-Xiong She, George S. Eisenbarth, Marian Rewers, John A. Todd, Beena Akolkar, Patrick Concannon, Henry A. Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Flemming Pociot, Stephen S. Rich and and the Type 1 Diabetes Genetics Consortium

Diabetes 2012 Nov; 61 (11): 3012-3017. https://doi.org/10.2337/db11-1694

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Constitutive and Inflammatory Immunopeptidome of Pancreatic β-Cells
Nadine L. Dudek, Chor Teck Tan, Dhana G. Gorasia, Nathan P. Croft, Patricia T. Illing and Anthony W. Purcell

Diabetes 2012 Nov; 61 (11): 3018-3025. https://doi.org/10.2337/db11-1333

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Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 DiabetesTwo Independent Studies
Qibin Qi, John P. Forman, Majken K. Jensen, Alan Flint, Gary C. Curhan, Eric B. Rimm, Frank B. Hu and Lu Qi

Diabetes 2012 Nov; 61 (11): 3026-3032. https://doi.org/10.2337/db12-0225

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Issues and Events

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Issues and Events
Diabetes 2012 Nov; 61 (11): 3033. https://doi.org/10.2337/db12-ie11

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Diabetes Digests

Open Access
Highlights From the Latest in Diabetes Research
Diabetes 2012 Nov; 61 (11): 3034-3035. https://doi.org/10.2337/db12-dd11

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Table of Contents

Commentaries

Methodology Reviews

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Genetics/Genomes/Proteomics/Metabolomics

Issues and Events

Diabetes Digests

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