Pathophysiology

Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa

  1. Maarit Oikarinen1⇓,
  2. Sisko Tauriainen1,
  3. Sami Oikarinen1,
  4. Teemu Honkanen2,
  5. Pekka Collin3,
  6. Immo Rantala2,4,
  7. Markku Mäki5,6,
  8. Katri Kaukinen3 and
  9. Heikki Hyöty1,7
  1. 1Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
  2. 2Department of Pathology, School of Medicine, University of Tampere, Tampere, Finland
  3. 3Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, and School of Medicine, University of Tampere, Tampere, Finland
  4. 4Department of Pathology, Centre of Laboratory Medicine, Tampere University Hospital, Tampere, Finland
  5. 5Pediatric Research Centre, School of Medicine, University of Tampere, Tampere, Finland
  6. 6Department of Pediatrics, Tampere University Hospital, Tampere, Finland
  7. 7Department of Clinical Microbiology, Centre of Laboratory Medicine, Tampere University Hospital, Tampere, Finland
  1. Corresponding author: Maarit Oikarinen, maarit.oikarinen{at}uta.fi.
Diabetes 2012 Mar; 61(3): 687-691. https://doi.org/10.2337/db11-1157

Article Figures & Tables

Figures

  • FIG. 1.
    FIG. 1.

    Detection of enterovirus RNA by ISH in intestinal biopsies of type 1 diabetic patients including weak-positive (A), moderate-positive (B), and strong-positive (C) cases. D: Immunohistochemical staining for enterovirus VP1 protein. Arrows point to cells positive for enterovirus RNA (A) and VP1 protein (D). (A high-quality digital representation of this figure is available in the online issue.)

Tables

  • TABLE 1
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  • TABLE 4
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Diabetes: 61 (3)

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March 2012, 61(3)
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Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa
Maarit Oikarinen, Sisko Tauriainen, Sami Oikarinen, Teemu Honkanen, Pekka Collin, Immo Rantala, Markku Mäki, Katri Kaukinen, Heikki Hyöty
Diabetes Mar 2012, 61 (3) 687-691; DOI: 10.2337/db11-1157
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