Pathophysiology

Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa

Maarit Oikarinen¹ ⇓,
Sisko Tauriainen¹,
Sami Oikarinen¹,
Teemu Honkanen²,
Pekka Collin³,
Immo Rantala²,⁴,
Markku Mäki⁵,⁶,
Katri Kaukinen³ and
Heikki Hyöty¹,⁷

¹Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
²Department of Pathology, School of Medicine, University of Tampere, Tampere, Finland
³Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, and School of Medicine, University of Tampere, Tampere, Finland
⁴Department of Pathology, Centre of Laboratory Medicine, Tampere University Hospital, Tampere, Finland
⁵Pediatric Research Centre, School of Medicine, University of Tampere, Tampere, Finland
⁶Department of Pediatrics, Tampere University Hospital, Tampere, Finland
⁷Department of Clinical Microbiology, Centre of Laboratory Medicine, Tampere University Hospital, Tampere, Finland

Corresponding author: Maarit Oikarinen, maarit.oikarinen{at}uta.fi.

Diabetes 2012 Mar; 61(3): 687-691. https://doi.org/10.2337/db11-1157

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FIG. 1.
Detection of enterovirus RNA by ISH in intestinal biopsies of type 1 diabetic patients including weak-positive (A), moderate-positive (B), and strong-positive (C) cases. D: Immunohistochemical staining for enterovirus VP1 protein. Arrows point to cells positive for enterovirus RNA (A) and VP1 protein (D). (A high-quality digital representation of this figure is available in the online issue.)

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