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Genetics/Genomes/Proteomics/Metabolomics

Genetic Predisposition to Dyslipidemia and Type 2 Diabetes Risk in Two Prospective Cohorts

  1. Qibin Qi1,
  2. Liming Liang2,
  3. Alessandro Doria3,4,
  4. Frank B. Hu1,2,5 and
  5. Lu Qi1,5⇓
  1. 1Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts
  2. 2Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
  3. 3Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
  4. 4Department of Medicine, Harvard Medical School, Boston, Massachusetts
  5. 5Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
  1. Corresponding author: Lu Qi, nhlqi{at}channing.harvard.edu.
Diabetes 2012 Mar; 61(3): 745-752. https://doi.org/10.2337/db11-1254
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Abstract

Dyslipidemia has been associated with type 2 diabetes, but it remains unclear whether dyslipidemia plays a causal role in type 2 diabetes. We aimed to examine the association between the genetic predisposition to dyslipdemia and type 2 diabetes risk. The current study included 2,447 patients with type 2 diabetes and 3,052 control participants of European ancestry from the Nurses’ Health Study and the Health Professionals Follow-up Study. Genetic predisposition to dyslipidemia was estimated by three genotype scores of lipids (LDL cholesterol, HDL cholesterol, and triglycerides) on the basis of the established loci for blood lipids. Linear relation analysis indicated that the HDL cholesterol and triglyceride genotype scores, but not the LDL cholesterol genotype score, were linearly related to elevated type 2 diabetes risk. Each point of the HDL cholesterol and triglyceride genotype scores was associated with a 3% (odds ratio [OR] 1.03 [95% CI 1.01–1.04]) and a 2% (1.02 [1.00–1.04]) increased risk of developing type 2 diabetes, respectively. The ORs were 1.39 (1.17–1.65) and 1.19 (1.01–1.41) for type 2 diabetes by comparing extreme quartiles of the HDL cholesterol genotype score and triglyceride genotype score, respectively. In conclusion, genetic predisposition to low HDL cholesterol or high triglycerides is related to elevated type 2 diabetes risk.

Footnotes

  • This article contains Supplementary Data online at http://diabetes.diabetesjournals.org/lookup/suppl/doi:10.2337/db11-1254/-/DC1.

  • Received September 8, 2011.
  • Accepted December 3, 2011.
  • © 2012 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Diabetes: 61 (3)

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March 2012, 61(3)
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Genetic Predisposition to Dyslipidemia and Type 2 Diabetes Risk in Two Prospective Cohorts
Qibin Qi, Liming Liang, Alessandro Doria, Frank B. Hu, Lu Qi
Diabetes Mar 2012, 61 (3) 745-752; DOI: 10.2337/db11-1254

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Genetic Predisposition to Dyslipidemia and Type 2 Diabetes Risk in Two Prospective Cohorts
Qibin Qi, Liming Liang, Alessandro Doria, Frank B. Hu, Lu Qi
Diabetes Mar 2012, 61 (3) 745-752; DOI: 10.2337/db11-1254
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