Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium

Christopher A. Haiman; Megan D. Fesinmeyer; Kylee L. Spencer; Petra Bůžková; V. Saroja Voruganti; Peggy Wan; Jeff Haessler; Nora Franceschini; Kristine R. Monroe; Barbara V. Howard; Rebecca D. Jackson; Jose C. Florez; Laurence N. Kolonel; Steven Buyske; Robert J. Goodloe; Simin Liu; JoAnn E. Manson; James B. Meigs; Kevin Waters; Kenneth J. Mukamal; Sarah A. Pendergrass; Peter Shrader; Lynne R. Wilkens; Lucia A. Hindorff; Jose Luis Ambite; Kari E. North; Ulrike Peters; Dana C. Crawford; Loic Le Marchand; James S. Pankow

doi:10.2337/db11-1296

Genetics/Genomes/Proteomics/Metabolomics

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations

The Population Architecture using Genomics and Epidemiology (PAGE) Consortium

Christopher A. Haiman¹ ⇓,
Megan D. Fesinmeyer²,
Kylee L. Spencer³,
Petra Bůžková⁴,
V. Saroja Voruganti⁵,
Peggy Wan¹,
Jeff Haessler²,
Nora Franceschini⁶,
Kristine R. Monroe¹,
Barbara V. Howard⁷,
Rebecca D. Jackson⁸,
Jose C. Florez⁹,¹⁰,¹¹,
Laurence N. Kolonel¹²,
Steven Buyske¹³,
Robert J. Goodloe³,
Simin Liu¹⁴,
JoAnn E. Manson⁹,¹⁵,
James B. Meigs⁹,¹⁶,
Kevin Waters¹,
Kenneth J. Mukamal¹⁷,
Sarah A. Pendergrass³,
Peter Shrader¹⁶,
Lynne R. Wilkens¹²,
Lucia A. Hindorff¹⁸,
Jose Luis Ambite¹⁹,
Kari E. North⁶,
Ulrike Peters²,
Dana C. Crawford³,
Loic Le Marchand¹² and
James S. Pankow²⁰

¹Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California
²Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
³Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee
⁴Department of Biostatistics, University of Washington, Seattle, Washington
⁵Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas
⁶Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina
⁷Medstar Health Research Institute and Georgetown University, Washington, D.C.
⁸Department of Internal Medicine, Ohio State University, Columbus, Ohio
⁹Harvard Medical School, Boston, Massachusetts
¹⁰Diabetes Unit and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts
¹¹Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts
¹²Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii
¹³Departments of Genetics and Statistics, Rutgers University, Piscataway, New Jersey
¹⁴Department of Epidemiology, School of Public Health, University of California, Los Angeles, California
¹⁵Brigham and Women's Hospital, Boston, Massachusetts
¹⁶General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts
¹⁷Beth Israel Deaconess Medical Center, Boston, Massachusetts
¹⁸Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland
¹⁹Information Sciences Institute, University of Southern California, Los Angeles, California
²⁰Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota