Diabetes: 62 (11)

November 01 2013; volume 62 issue 11

In This Issue

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In This Issue of Diabetes
Diabetes 2013 Nov; 62 (11): 3645-3646. https://doi.org/10.2337/db13-ti11

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Perspectives in Diabetes

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Endothelial-Podocyte Crosstalk: The Missing Link Between Endothelial Dysfunction and Albuminuria in Diabetes
Ferhan S. Siddiqi and Andrew Advani

Diabetes 2013 Nov; 62 (11): 3647-3655. https://doi.org/10.2337/db13-0795

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Commentaries

Open Access
The Compelling Case for Anti-CD3 in Type 1 Diabetes
Jay S. Skyler

Diabetes 2013 Nov; 62 (11): 3656-3657. https://doi.org/10.2337/db13-1157

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Location, Location, Location?Is the Pain of Diabetic Neuropathy Generated by Hyperactive Sensory Neurons?
Nigel A. Calcutt

Diabetes 2013 Nov; 62 (11): 3658-3660. https://doi.org/10.2337/db13-1158

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Cholesterol Accumulation in Podocytes: A Potential Novel Targetable Pathway in Diabetic Nephropathy
Alda Tufro

Diabetes 2013 Nov; 62 (11): 3661-3662. https://doi.org/10.2337/db13-1167

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How Does Pioglitazone Prevent Progression of Impaired Glucose Tolerance to Diabetes?
Saul M. Genuth

Diabetes 2013 Nov; 62 (11): 3663-3665. https://doi.org/10.2337/db13-1175

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ATP and Sulfonylurea Linkage in the K_ATP Channel Solves a Diabetes Puzzler
Peter Drain

Diabetes 2013 Nov; 62 (11): 3666-3668. https://doi.org/10.2337/db13-1194

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Depleting T Cells in Newly Diagnosed Autoimmune (Type 1) Diabetes—Are We Getting Anywhere?
Åke Lernmark

Diabetes 2013 Nov; 62 (11): 3669-3670. https://doi.org/10.2337/db13-1207

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Going With the Flow: Adaptation of β-Cell Function to Glucose Fluxes After Bariatric Surgery
Marzieh Salehi and David A. D’Alessio

Diabetes 2013 Nov; 62 (11): 3671-3673. https://doi.org/10.2337/db13-1213

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GABAergic System in β-Cells: From Autoimmunity Target to Regeneration Tool
Paolo Fiorina

Diabetes 2013 Nov; 62 (11): 3674-3676. https://doi.org/10.2337/db13-1243

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Methodology Review

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Assessing Decreased Sensation and Increased Sensory Phenomena in Diabetic Polyneuropathies
Peter J. Dyck, David N. Herrmann, Nathan P. Staff and P. James B. Dyck

Diabetes 2013 Nov; 62 (11): 3677-3686. https://doi.org/10.2337/db13-0352

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Technological Advances

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Age-Dependent Labeling and Imaging of Insulin Secretory Granules
Anna Ivanova, Yannis Kalaidzidis, Ronald Dirkx, Mihail Sarov, Michael Gerlach, Britta Schroth-Diez, Andreas Müller, Yanmei Liu, Cordula Andree, Bernard Mulligan, Carla Münster, Thomas Kurth, Marc Bickle, Stephan Speier, Konstantinos Anastassiadis and Michele Solimena

Diabetes 2013 Nov; 62 (11): 3687-3696. https://doi.org/10.2337/db12-1819

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Metabolism

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Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
Stefania Carobbio, Rachel M. Hagen, Christopher J. Lelliott, Marc Slawik, Gema Medina-Gomez, Chong-Yew Tan, Audrey Sicard, Helen J. Atherton, Nuria Barbarroja, Mikael Bjursell, Mohammad Bohlooly-Y, Sam Virtue, Antoinette Tuthill, Etienne Lefai, Martine Laville, Tingting Wu, Robert V. Considine, Hubert Vidal, Dominique Langin, Matej Oresic, Francisco J. Tinahones, Jose Manuel Fernandez-Real, Julian L. Griffin, Jaswinder K. Sethi, Miguel López and Antonio Vidal-Puig

Diabetes 2013 Nov; 62 (11): 3697-3708. https://doi.org/10.2337/db12-1748

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Obesity Studies

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Long-Term Effects of Bariatric Surgery on Meal Disposal and β-Cell Function in Diabetic and Nondiabetic Patients
Stefania Camastra, Elza Muscelli, Amalia Gastaldelli, Jens J. Holst, Brenno Astiarraga, Simona Baldi, Monica Nannipieri, Demetrio Ciociaro, Marco Anselmino, Andrea Mari and Ele Ferrannini

Diabetes 2013 Nov; 62 (11): 3709-3717. https://doi.org/10.2337/db13-0321

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Profilin-1 Haploinsufficiency Protects Against Obesity-Associated Glucose Intolerance and Preserves Adipose Tissue Immune Homeostasis
Giulio R. Romeo, Munkyong Pae, Delphine Eberlé, Jongsoon Lee and Steven E. Shoelson

Diabetes 2013 Nov; 62 (11): 3718-3726. https://doi.org/10.2337/db13-0050

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Maternal Obesity Induces Epigenetic Modifications to Facilitate Zfp423 Expression and Enhance Adipogenic Differentiation in Fetal Mice
Qi-Yuan Yang, Jun-Fang Liang, Carl J. Rogers, Jun-Xing Zhao, Mei-Jun Zhu and Min Du

Diabetes 2013 Nov; 62 (11): 3727-3735. https://doi.org/10.2337/db13-0433

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Overnutrition Stimulates Intestinal Epithelium Proliferation Through β-Catenin Signaling in Obese Mice
Jiaming Mao, Xiaomin Hu, Yao Xiao, Chao Yang, Yi Ding, Ning Hou, Jue Wang, Heping Cheng and Xiuqin Zhang

Diabetes 2013 Nov; 62 (11): 3736-3746. https://doi.org/10.2337/db13-0035

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Downregulation of CPPED1 Expression Improves Glucose Metabolism In Vitro in Adipocytes
Maija Vaittinen, Dorota Kaminska, Pirjo Käkelä, Matti Eskelinen, Marjukka Kolehmainen, Jussi Pihlajamäki, Matti Uusitupa and Leena Pulkkinen

Diabetes 2013 Nov; 62 (11): 3747-3750. https://doi.org/10.2337/db13-0830

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Islet Studies

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High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic IsletsInvolvement of Peroxisome Proliferator–Activated Receptor γ Signaling
Wing Yan So, Qianni Cheng, Lihua Chen, Carmella Evans-Molina, Aimin Xu, Karen S.L. Lam and Po Sing Leung

Diabetes 2013 Nov; 62 (11): 3751-3759. https://doi.org/10.2337/db13-0645

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γ-Aminobutyric Acid Regulates Both the Survival and Replication of Human β-Cells
Jide Tian, Hoa Dang, Zheying Chen, Alice Guan, Yingli Jin, Mark A. Atkinson and Daniel L. Kaufman

Diabetes 2013 Nov; 62 (11): 3760-3765. https://doi.org/10.2337/db13-0931

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Immunology and Transplantation

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Teplizumab (Anti-CD3 mAb) Treatment Preserves C-Peptide Responses in Patients With New-Onset Type 1 Diabetes in a Randomized Controlled TrialMetabolic and Immunologic Features at Baseline Identify a Subgroup of Responders
Kevan C. Herold, Stephen E. Gitelman, Mario R. Ehlers, Peter A. Gottlieb, Carla J. Greenbaum, William Hagopian, Karen D. Boyle, Lynette Keyes-Elstein, Sudeepta Aggarwal, Deborah Phippard, Peter H. Sayre, James McNamara, Jeffrey A. Bluestone and and the AbATE Study Team

Diabetes 2013 Nov; 62 (11): 3766-3774. https://doi.org/10.2337/db13-0345

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β-Cell–Specific IL-2 Therapy Increases Islet Foxp3⁺Treg and Suppresses Type 1 Diabetes in NOD Mice
Mark C. Johnson, Alaina L. Garland, Sarah C. Nicolson, Chengwen Li, R. Jude Samulski, Bo Wang and Roland Tisch

Diabetes 2013 Nov; 62 (11): 3775-3784. https://doi.org/10.2337/db13-0669

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Protection Against Type 1 Diabetes Upon Coxsackievirus B4 Infection and iNKT-Cell StimulationRole of Suppressive Macrophages
Liana Ghazarian, Julien Diana, Lucie Beaudoin, Pär G. Larsson, Raj K. Puri, Nico van Rooijen, Malin Flodström-Tullberg and Agnès Lehuen

Diabetes 2013 Nov; 62 (11): 3785-3796. https://doi.org/10.2337/db12-0958

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Pathophysiology

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A Mouse Model of Human Hyperinsulinism Produced by the E1506K Mutation in the Sulphonylurea Receptor SUR1
Kenju Shimomura, Maija Tusa, Michaela Iberl, Melissa F. Brereton, Stephan Kaizik, Peter Proks, Carolina Lahmann, Nagendra Yaluri, Shalem Modi, Hanna Huopio, Jarkko Ustinov, Timo Otonkoski, Markku Laakso and Frances M. Ashcroft

Diabetes 2013 Nov; 62 (11): 3797-3806. https://doi.org/10.2337/db12-1611

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Elastin-Derived Peptides Are New Regulators of Insulin Resistance Development in Mice
Sébastien Blaise, Béatrice Romier, Charlotte Kawecki, Maxime Ghirardi, Fanja Rabenoelina, Stéphanie Baud, Laurent Duca, Pascal Maurice, Andrea Heinz, Christian E.H. Schmelzer, Michel Tarpin, Laurent Martiny, Christian Garbar, Manuel Dauchez, Laurent Debelle and Vincent Durlach

Diabetes 2013 Nov; 62 (11): 3807-3816. https://doi.org/10.2337/db13-0508

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Complications

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Cyclodextrin Protects Podocytes in Diabetic Kidney Disease
Sandra Merscher-Gomez, Johanna Guzman, Christopher E. Pedigo, Markku Lehto, Robier Aguillon-Prada, Armando Mendez, Mariann I. Lassenius, Carol Forsblom, TaeHyun Yoo, Rodrigo Villarreal, Dony Maiguel, Kevin Johnson, Ronald Goldberg, Viji Nair, Ann Randolph, Matthias Kretzler, Robert G. Nelson, George W. Burke, Per-Henrik Groop, Alessia Fornoni and the FinnDiane Study Group

Diabetes 2013 Nov; 62 (11): 3817-3827. https://doi.org/10.2337/db13-0399

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Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Ca_v3.2 T-Type Calcium Channels
Peihan Orestes, Hari Prasad Osuru, William E. McIntire, Megan O. Jacus, Reza Salajegheh, Miljen M. Jagodic, WonJoo Choe, JeongHan Lee, Sang-Soo Lee, Kirstin E. Rose, Nathan Poiro, Michael R. DiGruccio, Katiresan Krishnan, Douglas F. Covey, Jung-Ha Lee, Paula Q. Barrett, Vesna Jevtovic-Todorovic and Slobodan M. Todorovic

Diabetes 2013 Nov; 62 (11): 3828-3838. https://doi.org/10.2337/db13-0813

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Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase
Varadarajan Sudhahar, Norifumi Urao, Jin Oshikawa, Ronald D. McKinney, Roxana M. Llanos, Julian F.B. Mercer, Masuko Ushio-Fukai and Tohru Fukai

Diabetes 2013 Nov; 62 (11): 3839-3850. https://doi.org/10.2337/db12-1228

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C-Peptide Activates AMPKα and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes
Mahendra Prasad Bhatt, Young-Cheol Lim, Young-Myeong Kim and Kwon-Soo Ha

Diabetes 2013 Nov; 62 (11): 3851-3862. https://doi.org/10.2337/db13-0039

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VEGF Secreted by Hypoxic Müller Cells Induces MMP-2 Expression and Activity in Endothelial Cells to Promote Retinal Neovascularization in Proliferative Diabetic Retinopathy
Murilo Rodrigues, Xiaoban Xin, Kathleen Jee, Savalan Babapoor-Farrokhran, Fabiana Kashiwabuchi, Tao Ma, Imran Bhutto, Syed Junaid Hassan, Yassine Daoud, David Baranano, Sharon Solomon, Gerard Lutty, Gregg L. Semenza, Silvia Montaner and Akrit Sodhi

Diabetes 2013 Nov; 62 (11): 3863-3873. https://doi.org/10.2337/db13-0014

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Inhibition of Src Kinase Blocks High Glucose–Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice
Kanta Taniguchi, Ling Xia, Howard J. Goldberg, Ken W.K. Lee, Anu Shah, Laura Stavar, Elodie A.Y. Masson, Abdul Momen, Eric A. Shikatani, Rohan John, Mansoor Husain and I. George Fantus

Diabetes 2013 Nov; 62 (11): 3874-3886. https://doi.org/10.2337/db12-1010

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Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance
Yajuan Qi, Zihui Xu, Qinglei Zhu, Candice Thomas, Rajesh Kumar, Hao Feng, David E. Dostal, Morris F. White, Kenneth M. Baker and Shaodong Guo

Diabetes 2013 Nov; 62 (11): 3887-3900. https://doi.org/10.2337/db13-0095

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Pharmacology and Therapeutics

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Teplizumab Preserves C-Peptide in Recent-Onset Type 1 DiabetesTwo-Year Results From the Randomized, Placebo-Controlled Protégé Trial
William Hagopian, Robert J. Ferry, Nicole Sherry, David Carlin, Ezio Bonvini, Syd Johnson, Kathryn E. Stein, Scott Koenig, Anastasia G. Daifotis, Kevan C. Herold, Johnny Ludvigsson and for the Protégé Trial Investigators

Diabetes 2013 Nov; 62 (11): 3901-3908. https://doi.org/10.2337/db13-0236

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Molecular Mechanism of Sulphonylurea Block of K_ATP Channels Carrying Mutations That Impair ATP Inhibition and Cause Neonatal Diabetes
Peter Proks, Heidi de Wet and Frances M. Ashcroft

Diabetes 2013 Nov; 62 (11): 3909-3919. https://doi.org/10.2337/db13-0531

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Prevention of Diabetes With Pioglitazone in ACT NOWPhysiologic Correlates
Ralph A. DeFronzo, Devjit Tripathy, Dawn C. Schwenke, MaryAnn Banerji, George A. Bray, Thomas A. Buchanan, Stephen C. Clement, Amalia Gastaldelli, Robert R. Henry, Abbas E. Kitabchi, Sunder Mudaliar, Robert E. Ratner, Frankie B. Stentz, Nicolas Musi, Peter D. Reaven and for the ACT NOW Study

Diabetes 2013 Nov; 62 (11): 3920-3926. https://doi.org/10.2337/db13-0265

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Rhein Protects Pancreatic β-Cells From Dynamin-Related Protein-1–Mediated Mitochondrial Fission and Cell Apoptosis Under Hyperglycemia
Jing Liu, Zhaohong Chen, Yujing Zhang, Mingchao Zhang, Xiaodong Zhu, Yun Fan, Shaolin Shi, Ke Zen and Zhihong Liu

Diabetes 2013 Nov; 62 (11): 3927-3935. https://doi.org/10.2337/db13-0251

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Genetics/Genomes/Proteomics/Metabolomics

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A New Strategy for Early Diagnosis of Type 2 Diabetes by Standard-Free, Label-Free LC-MS/MS Quantification of Glycated Peptides
Mei Zhang, Wei Xu and Yulin Deng

Diabetes 2013 Nov; 62 (11): 3936-3942. https://doi.org/10.2337/db13-0347

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Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation
Lori L. Bonnycastle, Peter S. Chines, Takashi Hara, Jeroen R. Huyghe, Amy J. Swift, Pirkko Heikinheimo, Jana Mahadevan, Sirkku Peltonen, Hanna Huopio, Pirjo Nuutila, Narisu Narisu, Rachel L. Goldfeder, Michael L. Stitzel, Simin Lu, Michael Boehnke, Fumihiko Urano, Francis S. Collins and Markku Laakso

Diabetes 2013 Nov; 62 (11): 3943-3950. https://doi.org/10.2337/db13-0571

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Decreased Cord-Blood Phospholipids in Young Age–at–Onset Type 1 Diabetes
Daria La Torre, Tuulikki Seppänen-Laakso, Helena E. Larsson, Tuulia Hyötyläinen, Sten A. Ivarsson, Åke Lernmark, Matej Orešič and and the DiPiS Study Group

Diabetes 2013 Nov; 62 (11): 3951-3956. https://doi.org/10.2337/db13-0215

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Issues and Events

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Issues and Events
Diabetes 2013 Nov; 62 (11): 3957. https://doi.org/10.2337/db13-ie11

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Diabetes Digests

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Highlights From the Latest in Diabetes Research
Diabetes 2013 Nov; 62 (11): 3958-3959. https://doi.org/10.2337/db13-dd11

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Table of Contents

In This Issue

Perspectives in Diabetes

Commentaries

Methodology Review

Technological Advances

Metabolism

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics/Genomes/Proteomics/Metabolomics

Issues and Events

Diabetes Digests

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