Diabetes: 62 (12)

December 01 2013; volume 62 issue 12

In This Issue

Open Access
In This Issue of Diabetes
Diabetes 2013 Dec; 62 (12): 3961-3962. https://doi.org/10.2337/db13-ti12

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Perspectives in Diabetes

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Celebrating 30 Years of Research Accomplishments of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study
Judith E. Fradkin, Catherine C. Cowie, Mary C. Hanlon and Griffin P. Rodgers

Diabetes 2013 Dec; 62 (12): 3963-3967. https://doi.org/10.2337/db13-1108

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An Update on the Molecular Actions of Fenofibrate and Its Clinical Effects on Diabetic Retinopathy and Other Microvascular End Points in Patients With Diabetes
Jonathan E. Noonan, Alicia J. Jenkins, Jian-Xing Ma, Anthony C. Keech, Jie Jin Wang and Ecosse L. Lamoureux

Diabetes 2013 Dec; 62 (12): 3968-3975. https://doi.org/10.2337/db13-0800

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Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study at 30 Years: Advances and Contributions
David M. Nathan, Margaret Bayless, Patricia Cleary, Saul Genuth, Rose Gubitosi-Klug, John M. Lachin, Gayle Lorenzi, Bernard Zinman and for the DCCT/EDIC Research Group

Diabetes 2013 Dec; 62 (12): 3976-3986. https://doi.org/10.2337/db13-1093

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Commentaries

Open Access
Soaping Up Type 2 Diabetes With Bile Acids?The Link Between Glucose and Bile Acid Metabolism in Humans Tightens: Quality Matters!
Bart Staels and Janne Prawitt

Diabetes 2013 Dec; 62 (12): 3987-3989. https://doi.org/10.2337/db13-1278

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Following the Fate of the Failing β-Cell: New Insights From First-Phase Insulin Responses
Alistair J.K. Williams and Anna E. Long

Diabetes 2013 Dec; 62 (12): 3990-3992. https://doi.org/10.2337/db13-1314

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Antagonizing Wnt Pathway in Diabetic Retinopathy
Ling Zhao, Sherrina H. Patel, Jacqueline Pei and Kang Zhang

Diabetes 2013 Dec; 62 (12): 3993-3995. https://doi.org/10.2337/db13-1309

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New Insights Into Metabolic Regulation via Bifurcated Function of Estrogen Receptor α
Tsutomu Wada, Hiroshi Tsuneki and Toshiyasu Sasaoka

Diabetes 2013 Dec; 62 (12): 3996-3998. https://doi.org/10.2337/db13-1325

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Lactate and the Mechanism of Hypoglycemia-Associated Autonomic Failure in Diabetes
Ana María Arbeláez and Philip E. Cryer

Diabetes 2013 Dec; 62 (12): 3999-4001. https://doi.org/10.2337/db13-1360

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STAT4: An Initiator of Meta-Inflammation in Adipose Tissue?
Nelson H. Knudsen and Chih-Hao Lee

Diabetes 2013 Dec; 62 (12): 4002-4003. https://doi.org/10.2337/db13-1416

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Vascularization of the Pancreas: An Evolving Role From Embryogenesis to Adulthood
Bertrand Duvillié

Diabetes 2013 Dec; 62 (12): 4004-4005. https://doi.org/10.2337/db13-1421

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The Vascular Endothelium, a Benign Restrictive Barrier? NO! Role of Nitric Oxide in Regulating Insulin Action
Joyce M. Richey

Diabetes 2013 Dec; 62 (12): 4006-4008. https://doi.org/10.2337/db13-1395

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Open Access
Islet Autoantibody Testing: An End to the Trials and Tribulations?
Polly J. Bingley and Alistair J.K. Williams

Diabetes 2013 Dec; 62 (12): 4009-4011. https://doi.org/10.2337/db13-1445

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Technological Advances

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In Vivo Adeno-Associated Viral Vector–Mediated Genetic Engineering of White and Brown Adipose Tissue in Adult Mice
Veronica Jimenez, Sergio Muñoz, Estefania Casana, Cristina Mallol, Ivet Elias, Claudia Jambrina, Albert Ribera, Tura Ferre, Sylvie Franckhauser and Fatima Bosch

Diabetes 2013 Dec; 62 (12): 4012-4022. https://doi.org/10.2337/db13-0311

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Metabolism

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Direct Effects of TNF-α on Local Fuel Metabolism and Cytokine Levels in the Placebo-Controlled, Bilaterally Infused Human LegIncreased Insulin Sensitivity, Increased Net Protein Breakdown, and Increased IL-6 Release
Ermina Bach, Roni R. Nielsen, Mikkel H. Vendelbo, Andreas B. Møller, Niels Jessen, Mads Buhl, Thomas K- Hafstrøm, Lars Holm, Steen B. Pedersen, Henriette Pilegaard, Rasmus S. Biensø, Jens O.L. Jørgensen and Niels Møller

Diabetes 2013 Dec; 62 (12): 4023-4029. https://doi.org/10.2337/db13-0138

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Nitric Oxide Directly Promotes Vascular Endothelial Insulin Transport
Hong Wang, Aileen X. Wang, Kevin Aylor and Eugene J. Barrett

Diabetes 2013 Dec; 62 (12): 4030-4042. https://doi.org/10.2337/db13-0627

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Lower “Awake and Fed Thermogenesis” Predicts Future Weight Gain in Subjects With Abdominal Adiposity
Paolo Piaggi, Jonathan Krakoff, Clifton Bogardus and Marie S. Thearle

Diabetes 2013 Dec; 62 (12): 4043-4051. https://doi.org/10.2337/db13-0785

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Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease
Luca Valenti, Rosa M. Mendoza, Raffaela Rametta, Marco Maggioni, Chris Kitajewski, Carrie J. Shawber and Utpal B. Pajvani

Diabetes 2013 Dec; 62 (12): 4052-4062. https://doi.org/10.2337/db13-0769

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Prandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol
Fariba Shojaee-Moradie, Yuying Ma, Shaoying Lou, Roman Hovorka and A. Margot Umpleby

Diabetes 2013 Dec; 62 (12): 4063-4069. https://doi.org/10.2337/db13-0935

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Glucose-6-Phosphate–Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis
Alexander von Wilamowitz-Moellendorff, Roger W. Hunter, Mar García-Rocha, Li Kang, Iliana López-Soldado, Louise Lantier, Kashyap Patel, Mark W. Peggie, Carlos Martínez-Pons, Martin Voss, Joaquim Calbó, Patricia T.W. Cohen, David H. Wasserman, Joan J. Guinovart and Kei Sakamoto

Diabetes 2013 Dec; 62 (12): 4070-4082. https://doi.org/10.2337/db13-0880

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Time Lag of Glucose From Intravascular to Interstitial Compartment in Humans
Ananda Basu, Simmi Dube, Michael Slama, Isabel Errazuriz, Jose Carlos Amezcua, Yogish C. Kudva, Thomas Peyser, Rickey E. Carter, Claudio Cobelli and Rita Basu

Diabetes 2013 Dec; 62 (12): 4083-4087. https://doi.org/10.2337/db13-1132

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Signal Transduction

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Gestational Diabetes Mellitus Impairs Nrf2-Mediated Adaptive Antioxidant Defenses and Redox Signaling in Fetal Endothelial Cells In Utero
Xinghua Cheng, Sarah J. Chapple, Bijal Patel, William Puszyk, David Sugden, Xiaoke Yin, Manuel Mayr, Richard C.M. Siow and Giovanni E. Mann

Diabetes 2013 Dec; 62 (12): 4088-4097. https://doi.org/10.2337/db13-0169

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Obesity Studies

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Prevention of Obesity and Insulin Resistance by Estrogens Requires ERα Activation Function-2 (ERαAF-2), Whereas ERαAF-1 Is Dispensable
Sandra Handgraaf, Elodie Riant, Aurélie Fabre, Aurélie Waget, Rémy Burcelin, Philippe Lière, Andrée Krust, Pierre Chambon, Jean-François Arnal and Pierre Gourdy

Diabetes 2013 Dec; 62 (12): 4098-4108. https://doi.org/10.2337/db13-0282

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STAT4 Deficiency Reduces Obesity-Induced Insulin Resistance and Adipose Tissue Inflammation
Anca D. Dobrian, Elena V. Galkina, Qian Ma, Margaret Hatcher, Sabai Myo Aye, Mathew J. Butcher, Kaiwen Ma, Bronson A. Haynes, Mark H. Kaplan and Jerry L. Nadler

Diabetes 2013 Dec; 62 (12): 4109-4121. https://doi.org/10.2337/db12-1275

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PPARα and Sirt1 Mediate Erythropoietin Action in Increasing Metabolic Activity and Browning of White Adipocytes to Protect Against Obesity and Metabolic Disorders
Li Wang, Ruifeng Teng, Lijun Di, Heather Rogers, Hong Wu, Jeffrey B. Kopp and Constance Tom Noguchi

Diabetes 2013 Dec; 62 (12): 4122-4131. https://doi.org/10.2337/db13-0518

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Programmed Cell Death-4 Deficiency Prevents Diet-Induced Obesity, Adipose Tissue Inflammation, and Insulin Resistance
Qun Wang, Zhaojing Dong, Xianglan Liu, Xingguo Song, Qiang Song, Qianwen Shang, Yang Jiang, Chun Guo and Lining Zhang

Diabetes 2013 Dec; 62 (12): 4132-4143. https://doi.org/10.2337/db13-0097

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Islet Studies

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Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis
Chunhua Dai, Marcela Brissova, Rachel B. Reinert, Lara Nyman, Eric H. Liu, Courtney Thompson, Alena Shostak, Masakazu Shiota, Takamune Takahashi and Alvin C. Powers

Diabetes 2013 Dec; 62 (12): 4144-4153. https://doi.org/10.2337/db12-1657

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Vascular Endothelial Growth Factor-A and Islet Vascularization Are Necessary in Developing, but Not Adult, Pancreatic Islets
Rachel B. Reinert, Marcela Brissova, Alena Shostak, Fong Cheng Pan, Greg Poffenberger, Qing Cai, Gregory L. Hundemer, Jeannelle Kantz, Courtney S. Thompson, Chunhua Dai, Owen P. McGuinness and Alvin C. Powers

Diabetes 2013 Dec; 62 (12): 4154-4164. https://doi.org/10.2337/db13-0071

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Conditional Hypovascularization and Hypoxia in Islets Do Not Overtly Influence Adult β-Cell Mass or Function
Joke D'Hoker, Nico De Leu, Yves Heremans, Luc Baeyens, Kohtaro Minami, Cai Ying, Astrid Lavens, Marie Chintinne, Geert Stangé, Judith Magenheim, Avital Swisa, Geert Martens, Daniel Pipeleers, Mark van de Casteele, Susumo Seino, Eli Keshet, Yuval Dor and Harry Heimberg

Diabetes 2013 Dec; 62 (12): 4165-4173. https://doi.org/10.2337/db12-1827

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Immunology and Transplantation

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GAD65 Autoantibodies Detected by Electrochemiluminescence Assay Identify High Risk for Type 1 Diabetes
Dongmei Miao, K. Michelle Guyer, Fran Dong, Ling Jiang, Andrea K. Steck, Marian Rewers, George S. Eisenbarth and Liping Yu

Diabetes 2013 Dec; 62 (12): 4174-4178. https://doi.org/10.2337/db13-0534

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Pathophysiology

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Acceleration of the Loss of the First-Phase Insulin Response During the Progression to Type 1 Diabetes in Diabetes Prevention Trial–Type 1 Participants
Jay M. Sosenko, Jay S. Skyler, Craig A. Beam, Jeffrey P. Krischer, Carla J. Greenbaum, Jeffrey Mahon, Lisa E. Rafkin, Della Matheson, Kevan C. Herold, Jerry P. Palmer and and the Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups

Diabetes 2013 Dec; 62 (12): 4179-4183. https://doi.org/10.2337/db13-0656

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Human Insulin Resistance Is Associated With Increased Plasma Levels of 12α-Hydroxylated Bile Acids
Rebecca A. Haeusler, Brenno Astiarraga, Stefania Camastra, Domenico Accili and Ele Ferrannini

Diabetes 2013 Dec; 62 (12): 4184-4191. https://doi.org/10.2337/db13-0639

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TRIB3 Mediates Glucose-Induced Insulin Resistance via a Mechanism That Requires the Hexosamine Biosynthetic Pathway
Wei Zhang, Jiarong Liu, Ling Tian, Qinglan Liu, Yuchang Fu and W. Timothy Garvey

Diabetes 2013 Dec; 62 (12): 4192-4200. https://doi.org/10.2337/db13-0312

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Genetic Disruption of SOD1 Gene Causes Glucose Intolerance and Impairs β-Cell Function
Giovanna Muscogiuri, Adam B. Salmon, Cristina Aguayo-Mazzucato, Mengyao Li, Bogdan Balas, Rodolfo Guardado-Mendoza, Andrea Giaccari, Robert L. Reddick, Sara M. Reyna, Gordon Weir, Ralph A. DeFronzo, Holly Van Remmen and Nicolas Musi

Diabetes 2013 Dec; 62 (12): 4201-4207. https://doi.org/10.2337/db13-0314

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Diminished Adenosine A1 Receptor Expression in Pancreatic α-Cells May Contribute to the Pathology of Type 1 Diabetes
Linda Yip, Cariel Taylor, Chan C. Whiting and C. Garrison Fathman

Diabetes 2013 Dec; 62 (12): 4208-4219. https://doi.org/10.2337/db13-0614

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Complications

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Effects of a Single Bout of Interval Hypoxia on Cardiorespiratory Control in Patients With Type 1 Diabetes
Tobias Duennwald, Luciano Bernardi, Daniel Gordin, Anna Sandelin, Anna Syreeni, Christopher Fogarty, Janne P. Kytö, Hannes Gatterer, Markku Lehto, Sohvi Hörkkö, Carol Forsblom, Martin Burtscher, Per-Henrik Groop and on behalf of the FinnDiane Study Group

Diabetes 2013 Dec; 62 (12): 4220-4227. https://doi.org/10.2337/db13-0167

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Antiangiogenic and Antineuroinflammatory Effects of Kallistatin Through Interactions With the Canonical Wnt Pathway
Xiaochen Liu, Bin Zhang, Jeffrey D. McBride, Kevin Zhou, Kyungwon Lee, Yueping Zhou, Zuguo Liu and Jian-xing Ma

Diabetes 2013 Dec; 62 (12): 4228-4238. https://doi.org/10.2337/db12-1710

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Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes
Owen Chan, Sachin A. Paranjape, Adam Horblitt, Wanling Zhu and Robert S. Sherwin

Diabetes 2013 Dec; 62 (12): 4239-4246. https://doi.org/10.2337/db13-0770

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Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5′-Triphosphate Cyclohydrolase 1 Instigate Its Ubiquitination in Diabetes
Yu Zhao, Jiliang Wu, Huaiping Zhu, Ping Song and Ming-Hui Zou

Diabetes 2013 Dec; 62 (12): 4247-4256. https://doi.org/10.2337/db13-0751

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Increased Persistent Sodium Current Due to Decreased PI3K Signaling Contributes to QT Prolongation in the Diabetic Heart
Zhongju Lu, Ya-Ping Jiang, Chia-Yen C. Wu, Lisa M. Ballou, Shengnan Liu, Eileen S. Carpenter, Michael R. Rosen, Ira S. Cohen and Richard Z. Lin

Diabetes 2013 Dec; 62 (12): 4257-4265. https://doi.org/10.2337/db13-0420

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Adipose Mesenchymal Stromal Cells Isolated From Type 2 Diabetic Patients Display Reduced Fibrinolytic Activity
Lourdes Acosta, Abdelkrim Hmadcha, Natalia Escacena, Inmaculada Pérez-Camacho, Antonio de la Cuesta, Rafael Ruiz-Salmeron, Benoit R. Gauthier and Bernat Soria

Diabetes 2013 Dec; 62 (12): 4266-4269. https://doi.org/10.2337/db13-0896

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Genetics/Genomes/Proteomics/Metabolomics

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Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach
Cristina Menni, Eric Fauman, Idil Erte, John R.B. Perry, Gabi Kastenmüller, So-Youn Shin, Ann-Kristin Petersen, Craig Hyde, Maria Psatha, Kirsten J. Ward, Wei Yuan, Mike Milburn, Colin N.A. Palmer, Timothy M. Frayling, Jeff Trimmer, Jordana T. Bell, Christian Gieger, Rob P. Mohney, Mary Julia Brosnan, Karsten Suhre, Nicole Soranzo and Tim D. Spector

Diabetes 2013 Dec; 62 (12): 4270-4276. https://doi.org/10.2337/db13-0570

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Genetic Variation in CDH13 Is Associated With Lower Plasma Adiponectin Levels but Greater Adiponectin Sensitivity in East Asian Populations
He Gao, Yu-Mi Kim, Peng Chen, Michiya Igase, Ryuichi Kawamoto, Mi Kyung Kim, Katsuhiko Kohara, Jeannette Lee, Tetsuro Miki, Rick Twee-Hee Ong, Hiroshi Onuma, Haruhiko Osawa, Xueling Sim, Yik Ying Teo, Yasuharu Tabara, E Shyong Tai and Rob M. van Dam

Diabetes 2013 Dec; 62 (12): 4277-4283. https://doi.org/10.2337/db13-0129

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Errata

Open Access
Identification of metabolic modifiers that underlie phenotypic variations in energy-balance regulation. Diabetes 2011;60:726–734
CL Chang, JJ Cai, PJ Cheng, HY Chueh and SYT Hsu

Diabetes 2013 Dec; 62 (12): 4284. https://doi.org/10.2337/db13-er12

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Direct Effects of Exendin-(9,39) and GLP-1-(9,36)amide on Insulin Action, β-Cell Function, and Glucose Metabolism in Nondiabetic Subjects. Diabetes 2013;62:2752–2756
M Sathananthan, LP Farrugia, JM Miles, F Piccinini, C Dalla Man, AR Zinsmeister, C Cobelli, RA Rizza and A Vella

Diabetes 2013 Dec; 62 (12): 4284. https://doi.org/10.2337/db13-er12a

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Issues and Events

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Issues and Events
Diabetes 2013 Dec; 62 (12): 4285. https://doi.org/10.2337/db13-ie12

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Diabetes Digests

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Highlights From the Latest in Diabetes Research
Diabetes 2013 Dec; 62 (12): 4286-4287. https://doi.org/10.2337/db13-dd12

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Online Letters to the Editor

Open Access
Comment on: Lazo et al. NH₂-Terminal Pro–Brain Natriuretic Peptide and Risk of Diabetes. Diabetes 2013;62:3189–3193
Cedric Moro, Jens Jordan and Andreas L. Birkenfeld

Diabetes 2013 Dec; 62 (12): e28. https://doi.org/10.2337/db13-1034

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Comment on: Sitnick et al. Skeletal Muscle Triacylglycerol Hydrolysis Does Not Influence Metabolic Complications of Obesity. Diabetes 2013;62:3350–3361
Cedric Moro and Dominique Langin

Diabetes 2013 Dec; 62 (12): e29. https://doi.org/10.2337/db13-1107

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Comment on: Sukumar et al. Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction. Diabetes 2013;62:2130–2134
Karin A.M. Jandeleit-Dahm and Harald H.H.W. Schmidt

Diabetes 2013 Dec; 62 (12): e30. https://doi.org/10.2337/db13-1286

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Response to Comment on: Sukumar et al. Nox2 NADPH Oxidase Has a Critical Role in Insulin Resistance–Related Endothelial Cell Dysfunction. Diabetes 2013;62:2130–2134
Piruthivi Sukumar and Mark T. Kearney

Diabetes 2013 Dec; 62 (12): e31. https://doi.org/10.2337/db13-1392

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Table of Contents

In This Issue

Perspectives in Diabetes

Commentaries

Technological Advances

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Genetics/Genomes/Proteomics/Metabolomics

Errata

Issues and Events

Diabetes Digests

Online Letters to the Editor

In this Issue

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