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Point-Counterpoint

Glucose Variability

  1. F. John Service
  1. From the Mayo College of Medicine, Mayo Clinic, Rochester, Minnesota
  1. Corresponding author: F. John Service, service.john{at}mayo.edu.
Diabetes 2013 May; 62(5): 1398-1404. https://doi.org/10.2337/db12-1396
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Abstract

The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenomenon of normal physiology. Comprehensive recording of glycemia is required for the generation of any measurement of glucose variability. To avoid distortion of variability to that of glycemic exposure, its calculation should be devoid of a time component.

  • © 2013 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Diabetes: 62 (5)

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May 2013, 62(5)
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Glucose Variability
F. John Service
Diabetes May 2013, 62 (5) 1398-1404; DOI: 10.2337/db12-1396

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Glucose Variability
F. John Service
Diabetes May 2013, 62 (5) 1398-1404; DOI: 10.2337/db12-1396
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  • Glucose Variability: Where It Is Important and How to Measure It
  • “Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance
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