Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
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vol. 63 no. 12 4369-4377
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History
- Received February 24, 2014
- Accepted July 15, 2014
- Published in print November 20, 2014.
- Published online ahead of print July 21, 2014.
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- Previous version (July 21, 2014 - 12:24).
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© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
Author Information
- Hanieh Yaghootkar1,
- Robert A. Scott2,
- Charles C. White3,4,
- Weihua Zhang5,
- Elizabeth Speliotes6,
- Patricia B. Munroe7,
- Georg B. Ehret8,9,
- Joshua C. Bis10,
- Caroline S. Fox3,11,12,
- Mark Walker13,
- Ingrid B. Borecki14,
- Joshua W. Knowles15,
- Laura Yerges-Armstrong16,
- Claes Ohlsson17,
- John R.B. Perry2,
- John C. Chambers5,
- Jaspal S. Kooner18,
- Nora Franceschini19,
- Claudia Langenberg2,20,
- Marie-France Hivert21,22,
- Zari Dastani23,
- J. Brent Richards24,25,
- Robert K. Semple26,27 and
- Timothy M. Frayling1⇑
- 1Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, U.K.
- 2MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, U.K.
- 3Framingham Heart Study, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA
- 4Department of Biostatistics, Boston University School of Public Health, Boston, MA
- 5Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, U.K.
- 6Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI
- 7Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, U.K.
- 8Cardiology Center, Geneva University Hospital, Geneva, Switzerland
- 9Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD
- 10Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, WA
- 11Center for Population Studies, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA
- 12Division of Endocrinology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA
- 13Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U.K.
- 14Department of Genetics, Washington University School of Medicine, St. Louis, MO
- 15Department of Medicine and Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA
- 16University of Maryland School of Medicine, Division of Endocrinology, Baltimore, MA
- 17Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
- 18Cardiovascular Science, National Heart and Lung Institute, Imperial College London, London, U.K.
- 19Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC
- 20Department of Epidemiology and Public Health, University College London, London, U.K.
- 21Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, Boston, MA
- 22General Medicine Division, Massachusetts General Hospital, Boston, MA
- 23Departments of Human Genetics and Epidemiology and Biostatistics, McGill University, Montreal, Quebec, Canada
- 24Department of Twin Research and Genetic Epidemiology, King’s College London, London, U.K.
- 25Department of Medicine, Human Genetics, Epidemiology, and Biostatistics, McGill University, Montreal, Quebec, Canada
- 26The National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, U.K.
- 27The University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, U.K.
- Corresponding author: Timothy M. Frayling, t.m.frayling{at}ex.ac.uk.
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December 2014, 63(12)
Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
