Diabetes: 63 (2)

February 01 2014; volume 63 issue 2

In This Issue

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In This Issue of Diabetes
Diabetes 2014 Feb; 63 (2): 379-380. https://doi.org/10.2337/db14-ti02

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Commentaries

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Irisin ERKs the Fat
Jun Wu and Bruce M. Spiegelman

Diabetes 2014 Feb; 63 (2): 381-383. https://doi.org/10.2337/db13-1586

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Enteroviral Infections and Development of Type 1 Diabetes: The Brothers Karamazov Within the CVBs
Francesco Dotta and Guido Sebastiani

Diabetes 2014 Feb; 63 (2): 384-386. https://doi.org/10.2337/db13-1441

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GLP-1—A Candidate Humoral Mediator for Glucose Control After Roux-en-Y Gastric Bypass
Jörg Schirra and Burkhard Göke

Diabetes 2014 Feb; 63 (2): 387-389. https://doi.org/10.2337/db13-1660

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LY2605541—A Preferential Hepato-Specific Insulin Analogue
Sten Madsbad

Diabetes 2014 Feb; 63 (2): 390-392. https://doi.org/10.2337/db13-1646

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Turning Off a Viral/Lipid Sensor Improves Type 2 Diabetes
Licio A. Velloso

Diabetes 2014 Feb; 63 (2): 393-395. https://doi.org/10.2337/db13-1704

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Functional MRI Signal Fluctuations: A Preclinical Biomarker for Cognitive Impairment in Type 2 Diabetes?
Renata Belfort-DeAguiar, R. Todd Constable and Robert S. Sherwin

Diabetes 2014 Feb; 63 (2): 396-398. https://doi.org/10.2337/db13-1685

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GLP-1: The Oracle for Gastric Bypass?
Gema Frühbeck and Ruben Nogueiras

Diabetes 2014 Feb; 63 (2): 399-401. https://doi.org/10.2337/db13-1708

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Aldose Reductase Meets Histone Acetylation: A New Role for an Old Player
Julia V. Busik and Maria B. Grant

Diabetes 2014 Feb; 63 (2): 402-404. https://doi.org/10.2337/db13-1696

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Toward Personalized Prevention of Obesity: Can Vitamin D Negate the FTO Effect?
Corinne D. Engelman

Diabetes 2014 Feb; 63 (2): 405-406. https://doi.org/10.2337/db13-1714

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Give the Receptor a Brake: Slowing Gastric Emptying by GLP-1
Jenny Tong and David D’Alessio

Diabetes 2014 Feb; 63 (2): 407-409. https://doi.org/10.2337/db13-1764

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Technological Advances

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Generation of L Cells in Mouse and Human Small Intestine Organoids
Natalia Petersen, Frank Reimann, Sina Bartfeld, Henner F. Farin, Femke C. Ringnalda, Robert G.J. Vries, Stieneke van den Brink, Hans Clevers, Fiona M. Gribble and Eelco J.P. de Koning

Diabetes 2014 Feb; 63 (2): 410-420. https://doi.org/10.2337/db13-0991

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Metabolism

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Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution
Jeb S. Orr, Arion Kennedy, Emily K. Anderson-Baucum, Corey D. Webb, Steve C. Fordahl, Keith M. Erikson, Yaofang Zhang, Anders Etzerodt, Søren K. Moestrup and Alyssa H. Hasty

Diabetes 2014 Feb; 63 (2): 421-432. https://doi.org/10.2337/db13-0213

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RNA-Binding Protein PTB and MicroRNA-221 Coregulate AdipoR1 Translation and Adiponectin Signaling
Yaniv Lustig, Ehud Barhod, Reut Ashwal-Fluss, Reut Gordin, Noam Shomron, Kfir Baruch-Umansky, Rina Hemi, Avraham Karasik and Hannah Kanety

Diabetes 2014 Feb; 63 (2): 433-445. https://doi.org/10.2337/db13-1032

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Coxsackievirus B1 Is Associated With Induction of β-Cell Autoimmunity That Portends Type 1 Diabetes
Olli H. Laitinen, Hanna Honkanen, Outi Pakkanen, Sami Oikarinen, Minna M. Hankaniemi, Heini Huhtala, Tanja Ruokoranta, Valérie Lecouturier, Philippe André, Raimo Harju, Suvi M. Virtanen, Jussi Lehtonen, Jeffrey W. Almond, Tuula Simell, Olli Simell, Jorma Ilonen, Riitta Veijola, Mikael Knip and Heikki Hyöty

Diabetes 2014 Feb; 63 (2): 446-455. https://doi.org/10.2337/db13-0619

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Myeloid-Cell Protein Tyrosine Phosphatase-1B Deficiency in Mice Protects Against High-Fat Diet and Lipopolysaccharide-Induced Inflammation, Hyperinsulinemia, and Endotoxemia Through an IL-10 STAT3-Dependent Mechanism
Louise Grant, Kirsty D. Shearer, Alicja Czopek, Emma K. Lees, Carl Owen, Abdelali Agouni, James Workman, Cristina Martin-Granados, John V. Forrester, Heather M. Wilson, Nimesh Mody and Mirela Delibegovic

Diabetes 2014 Feb; 63 (2): 456-470. https://doi.org/10.2337/db13-0885

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Lipopolysaccharides-Mediated Increase in Glucose-Stimulated Insulin Secretion: Involvement of the GLP-1 Pathway
Anh Thoai Nguyen, Stéphane Mandard, Cédric Dray, Valérie Deckert, Philippe Valet, Philippe Besnard, Daniel J. Drucker, Laurent Lagrost and Jacques Grober

Diabetes 2014 Feb; 63 (2): 471-482. https://doi.org/10.2337/db13-0903

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Contribution of Endogenous Glucagon-Like Peptide 1 to Glucose Metabolism After Roux-en-Y Gastric Bypass
Meera Shah, Jennie H. Law, Francesco Micheletto, Matheni Sathananthan, Chiara Dalla Man, Claudio Cobelli, Robert A. Rizza, Michael Camilleri, Alan R. Zinsmeister and Adrian Vella

Diabetes 2014 Feb; 63 (2): 483-493. https://doi.org/10.2337/db13-0954

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Novel PEGylated Basal Insulin LY2605541 Has a Preferential Hepatic Effect on Glucose Metabolism
Mary Courtney Moore, Marta S. Smith, Vikram P. Sinha, John M. Beals, M. Dodson Michael, Scott J. Jacober and Alan D. Cherrington

Diabetes 2014 Feb; 63 (2): 494-504. https://doi.org/10.2337/db13-0826

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GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats
Kirk M. Habegger, Kristy M. Heppner, Sarah E. Amburgy, Nickki Ottaway, Jenna Holland, Christine Raver, Erin Bartley, Timo D. Müller, Paul T. Pfluger, Jose Berger, Mouhamadoul Toure, Stephen C. Benoit, Richard D. DiMarchi, Diego Perez-Tilve, David A. D’Alessio, Randy J. Seeley and Matthias H. Tschöp

Diabetes 2014 Feb; 63 (2): 505-513. https://doi.org/10.2337/db13-0511

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Signal Transduction

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Irisin Stimulates Browning of White Adipocytes Through Mitogen-Activated Protein Kinase p38 MAP Kinase and ERK MAP Kinase Signaling
Yuan Zhang, Rui Li, Yan Meng, Shiwu Li, William Donelan, Yan Zhao, Lei Qi, Mingxiang Zhang, Xingli Wang, Taixing Cui, Li-Jun Yang and Dongqi Tang

Diabetes 2014 Feb; 63 (2): 514-525. https://doi.org/10.2337/db13-1106

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Small-Molecule Inhibitors of PKR Improve Glucose Homeostasis in Obese Diabetic Mice
Takahisa Nakamura, Alessandro Arduini, Brenna Baccaro, Masato Furuhashi and Gökhan S. Hotamisligil

Diabetes 2014 Feb; 63 (2): 526-534. https://doi.org/10.2337/db13-1019

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Obesity Studies

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Endothelial Cells From Visceral Adipose Tissue Disrupt Adipocyte Functions in a Three-Dimensional Setting: Partial Rescue by Angiopoietin-1
Vanessa Pellegrinelli, Christine Rouault, Nicolas Veyrie, Karine Clément and Danièle Lacasa

Diabetes 2014 Feb; 63 (2): 535-549. https://doi.org/10.2337/db13-0537

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ITCH Deficiency Protects From Diet-Induced Obesity
Arianna Marino, Rossella Menghini, Marta Fabrizi, Viviana Casagrande, Maria Mavilio, Robert Stoehr, Eleonora Candi, Alessandro Mauriello, Jose M. Moreno-Navarrete, María Gómez-Serrano, Belén Peral, Gerry Melino, Renato Lauro, Jose M. Fernandez Real and Massimo Federici

Diabetes 2014 Feb; 63 (2): 550-561. https://doi.org/10.2337/db13-0802

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Deletion of Class A Scavenger Receptor Deteriorates Obesity-Induced Insulin Resistance in Adipose Tissue
Xudong Zhu, Guijuan Zong, Liu Zhu, Yuchen Jiang, Ke Ma, Hanwen Zhang, Yan Zhang, Hui Bai, Qing Yang, Jingjing Ben, Xiaoyu Li, Yong Xu and Qi Chen

Diabetes 2014 Feb; 63 (2): 562-577. https://doi.org/10.2337/db13-0815

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Islet Studies

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G₀-G₁ Transition and the Restriction Point in Pancreatic β-Cells In Vivo
Ayat Hija, Seth Salpeter, Agnes Klochendler, Joseph Grimsby, Michael Brandeis, Benjamin Glaser and Yuval Dor

Diabetes 2014 Feb; 63 (2): 578-584. https://doi.org/10.2337/db12-1035

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SH2B1 in β-Cells Regulates Glucose Metabolism by Promoting β-Cell Survival and Islet Expansion
Zheng Chen, David L. Morris, Lin Jiang, Yong Liu and Liangyou Rui

Diabetes 2014 Feb; 63 (2): 585-595. https://doi.org/10.2337/db13-0666

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Autoantigen-Induced Focusing of Vβ13⁺ T Cells Precedes Onset of Autoimmune Diabetes in the LEW.1WR1 Rat
Ryan A. Eberwine, Laura Cort, Michael Habib, John P. Mordes and Elizabeth P. Blankenhorn

Diabetes 2014 Feb; 63 (2): 596-604. https://doi.org/10.2337/db13-0462

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Nrf2 Protects Pancreatic β-Cells From Oxidative and Nitrosative Stress in Diabetic Model Mice
Yoko Yagishita, Toshiaki Fukutomi, Akira Sugawara, Hiroshi Kawamura, Tetsu Takahashi, Jingbo Pi, Akira Uruno and Masayuki Yamamoto

Diabetes 2014 Feb; 63 (2): 605-618. https://doi.org/10.2337/db13-0909

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Immunology and Transplantation

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Induction of Diabetes in the RIP-B7.1 Mouse Model Is Critically Dependent on TLR3 and MyD88 Pathways and Is Associated With Alterations in the Intestinal Microbiome
Aimon K. Alkanani, Naoko Hara, Egil Lien, Diana Ir, Cassandra V. Kotter, Charles E. Robertson, Brandie D. Wagner, Daniel N. Frank and Danny Zipris

Diabetes 2014 Feb; 63 (2): 619-631. https://doi.org/10.2337/db13-1007

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pH of Drinking Water Influences the Composition of Gut Microbiome and Type 1 Diabetes Incidence
M. Hanief Sofi, Radhika Gudi, Subha Karumuthil-Melethil, Nicolas Perez, Benjamin M. Johnson and Chenthamarakshan Vasu

Diabetes 2014 Feb; 63 (2): 632-644. https://doi.org/10.2337/db13-0981

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Pathophysiology

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Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments
Jun Wang, Bing Gong, Wei Zhao, Cheuk Tang, Merina Varghese, Tuyen Nguyen, Weina Bi, Amanda Bilski, Shimul Begum, Prashant Vempati, Lindsay Knable, Lap Ho and Giulio M. Pasinetti

Diabetes 2014 Feb; 63 (2): 645-654. https://doi.org/10.2337/db13-1063

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Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes
Sami Oikarinen, Sisko Tauriainen, Didier Hober, Bernadette Lucas, Andriani Vazeou, Amirbabak Sioofy-Khojine, Evangelos Bozas, Peter Muir, Hanna Honkanen, Jorma Ilonen, Mikael Knip, Päivi Keskinen, Marja-Terttu Saha, Heini Huhtala, Glyn Stanway, Christos Bartsocas, Johnny Ludvigsson, Keith Taylor, Heikki Hyöty and the VirDiab Study Group

Diabetes 2014 Feb; 63 (2): 655-662. https://doi.org/10.2337/db13-0620

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Effects of Sitagliptin and Metformin Treatment on Incretin Hormone and Insulin Secretory Responses to Oral and “Isoglycemic” Intravenous Glucose
Irfan Vardarli, Elisabeth Arndt, Carolyn F. Deacon, Jens J. Holst and Michael A. Nauck

Diabetes 2014 Feb; 63 (2): 663-674. https://doi.org/10.2337/db13-0805

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A Critical Role for Thioredoxin-Interacting Protein in Diabetes-Related Impairment of Angiogenesis
Louise L. Dunn, Philippa J.L. Simpson, Hamish C. Prosser, Laura Lecce, Gloria S.C. Yuen, Andrew Buckle, Daniel P. Sieveking, Laura Z. Vanags, Patrick R. Lim, Renee W.Y. Chow, Yuen Ting Lam, Zoe Clayton, Shisan Bao, Michael J. Davies, Nadina Stadler, David S. Celermajer, Roland Stocker, Christina A. Bursill, John P. Cooke and Martin K.C. Ng

Diabetes 2014 Feb; 63 (2): 675-687. https://doi.org/10.2337/db13-0417

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Developmental Programming by Maternal Insulin Resistance: Hyperinsulinemia, Glucose Intolerance, and Dysregulated Lipid Metabolism in Male Offspring of Insulin-Resistant Mice
Elvira Isganaitis, Melissa Woo, Huijuan Ma, Michael Chen, Wen Kong, Aristides Lytras, Vicencia Sales, Jennifer DeCoste-Lopez, Kyung-Ju Lee, Cianna Leatherwood, Deborah Lee, Connor Fitzpatrick, Walter Gall, Steven Watkins and Mary-Elizabeth Patti

Diabetes 2014 Feb; 63 (2): 688-700. https://doi.org/10.2337/db13-0558

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Complications

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Podocyte-Specific GLUT4-Deficient Mice Have Fewer and Larger Podocytes and Are Protected From Diabetic Nephropathy
Johanna Guzman, Alexandra N. Jauregui, Sandra Merscher-Gomez, Dony Maiguel, Cristina Muresan, Alla Mitrofanova, Ana Diez-Sampedro, Joel Szust, Tae-Hyun Yoo, Rodrigo Villarreal, Christopher Pedigo, R. Damaris Molano, Kevin Johnson, Barbara Kahn, Bjoern Hartleben, Tobias B. Huber, Jharna Saha, George W. Burke, E. Dale Abel, Frank C. Brosius and Alessia Fornoni

Diabetes 2014 Feb; 63 (2): 701-714. https://doi.org/10.2337/db13-0752

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Genome-Wide Transcriptional Analysis of Differentially Expressed Genes in Diabetic, Healing Corneal Epithelial Cells: Hyperglycemia-Suppressed TGFβ3 Expression Contributes to the Delay of Epithelial Wound Healing in Diabetic Corneas
Ilham Bettahi, Haijing Sun, Nan Gao, Feng Wang, Xiaofan Mi, Weiping Chen, Zuguo Liu and Fu-Shin X. Yu

Diabetes 2014 Feb; 63 (2): 715-727. https://doi.org/10.2337/db13-1260

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Cerebral White Matter Integrity and Resting-State Functional Connectivity in Middle-aged Patients With Type 2 Diabetes
Wouter S. Hoogenboom, Thomas J. Marder, Veronica L. Flores, Susanne Huisman, Hana P. Eaton, Jason S. Schneiderman, Nicolas R. Bolo, Donald C. Simonson, Alan M. Jacobson, Marek Kubicki, Martha E. Shenton and Gail Musen

Diabetes 2014 Feb; 63 (2): 728-738. https://doi.org/10.2337/db13-1219

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Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial
John M. Lachin, Paula McGee, Jerry P. Palmer and for the DCCT/EDIC Research Group

Diabetes 2014 Feb; 63 (2): 739-748. https://doi.org/10.2337/db13-0881

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Altered Spontaneous Brain Activity in Type 2 Diabetes: A Resting-State Functional MRI Study
Ying Cui, Yun Jiao, Yu-Chen Chen, Kun Wang, Bo Gao, Song Wen, Shenghong Ju and Gao-Jun Teng

Diabetes 2014 Feb; 63 (2): 749-760. https://doi.org/10.2337/db13-0519

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Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals
Srinivasan Vedantham, Devi Thiagarajan, Radha Ananthakrishnan, Lingjie Wang, Rosa Rosario, Yu Shan Zou, Ira Goldberg, Shi Fang Yan, Ann Marie Schmidt and Ravichandran Ramasamy

Diabetes 2014 Feb; 63 (2): 761-774. https://doi.org/10.2337/db13-0032

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Pharmacology and Therapeutics

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OATP1B3 Is Expressed in Pancreatic β-Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide
Henriette E. Meyer zu Schwabedissen, Kerstin Boettcher, Tobias Steiner, Ute I. Schwarz, Markus Keiser, Heyo K. Kroemer and Werner Siegmund

Diabetes 2014 Feb; 63 (2): 775-784. https://doi.org/10.2337/db13-1005

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Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
Mahesh M. Umapathysivam, Michael Y. Lee, Karen L. Jones, Christopher E. Annink, Caroline E. Cousins, Laurence G. Trahair, Chris K. Rayner, Marianne J. Chapman, Michael A. Nauck, Michael Horowitz and Adam M. Deane

Diabetes 2014 Feb; 63 (2): 785-790. https://doi.org/10.2337/db13-0893

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Genetics/Genomes/Proteomics/Metabolomics

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BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans
Anna E. Thalacker-Mercer, Katherine H. Ingram, Fangjian Guo, Olga Ilkayeva, Christopher B. Newgard and W. Timothy Garvey

Diabetes 2014 Feb; 63 (2): 791-800. https://doi.org/10.2337/db13-0396

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Epigenome-Wide Association Study of Fasting Measures of Glucose, Insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network Study
Bertha Hidalgo, M. Ryan Irvin, Jin Sha, Degui Zhi, Stella Aslibekyan, Devin Absher, Hemant K. Tiwari, Edmond K. Kabagambe, Jose M. Ordovas and Donna K. Arnett

Diabetes 2014 Feb; 63 (2): 801-807. https://doi.org/10.2337/db13-1100

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FTO Genotype, Vitamin D Status, and Weight Gain During Childhood
Barbara H. Lourenço, Lu Qi, Walter C. Willett and Marly A. Cardoso

Diabetes 2014 Feb; 63 (2): 808-814. https://doi.org/10.2337/db13-1290

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Errata

Open Access
Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Diabetes 2006;55:2153–2156
Helen C. Freeman, Alison Hugill, Neil T. Dear, Frances M. Ashcroft and Roger D. Cox

Diabetes 2014 Feb; 63 (2): 815. https://doi.org/10.2337/db14-er02

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Prandial Hypertriglyceridemia in Metabolic Syndrome Is Due to an Overproduction of Both Chylomicron and VLDL Triacylglycerol. Diabetes 2013;62:4063–4069
Fariba Shojaee-Moradie, Yuying Ma, Shaoying Lou, Roman Hovorka and A. Margot Umpleby

Diabetes 2014 Feb; 63 (2): 815. https://doi.org/10.2337/db14-er02a

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Issues and Events

Open Access
Issues and Events
Diabetes 2014 Feb; 63 (2): 816. https://doi.org/10.2337/db14-ie02

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Table of Contents

In This Issue

Commentaries

Technological Advances

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics/Genomes/Proteomics/Metabolomics

Errata

Issues and Events

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