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Pathophysiology

Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

  1. Sami Oikarinen1⇑,
  2. Sisko Tauriainen1,2,
  3. Didier Hober3,
  4. Bernadette Lucas3,
  5. Andriani Vazeou4,
  6. Amirbabak Sioofy-Khojine1,
  7. Evangelos Bozas4,
  8. Peter Muir5,
  9. Hanna Honkanen1,
  10. Jorma Ilonen6,7,
  11. Mikael Knip8,9,10,11,
  12. Päivi Keskinen10,
  13. Marja-Terttu Saha10,
  14. Heini Huhtala12,
  15. Glyn Stanway13,
  16. Christos Bartsocas4,
  17. Johnny Ludvigsson14,
  18. Keith Taylor15,†,
  19. Heikki Hyöty1,16,
  20. the VirDiab Study Group*
  1. 1Department of Virology, University of Tampere, Tampere, Finland
  2. 2Department of Virology, University of Turku, Turku, Finland
  3. 3Laboratory of Virology EA3610, University Lille 2 and CHR, Lille, France
  4. 4Department of Pediatrics, Faculty of Nursing, National University of Athens, Athens, Greece
  5. 5King's College London, London, U.K.
  6. 6Immunogenetics Laboratory, University of Turku, Turku, Finland
  7. 7Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland
  8. 8Folkhälsan Research Center, Helsinki, Finland
  9. 9Children’s Hospital, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
  10. 10Department of Pediatrics, Tampere University Hospital and University of Tampere, Tampere, Finland
  11. 11Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland
  12. 12School of Health Sciences, University of Tampere, Tampere, Finland
  13. 13Department of Biological Sciences, University of Essex, Colchester, U.K.
  14. 14Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
  15. 15Queen Mary and Westfield College, London, U.K.
  16. 16Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
  1. Corresponding author: Sami Oikarinen, sami.oikarinen{at}uta.fi.
  • † Deceased.

Diabetes 2014 Feb; 63(2): 655-662. https://doi.org/10.2337/db13-0620
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Abstract

Enteroviruses (EVs) have been connected to type 1 diabetes in various studies. The current study evaluates the association between specific EV subtypes and type 1 diabetes by measuring type-specific antibodies against the group B coxsackieviruses (CVBs), which have been linked to diabetes in previous surveys. Altogether, 249 children with newly diagnosed type 1 diabetes and 249 control children matched according to sampling time, sex, age, and country were recruited in Finland, Sweden, England, France, and Greece between 2001 and 2005 (mean age 9 years; 55% male). Antibodies against CVB1 were more frequent among diabetic children than among control children (odds ratio 1.7 [95% CI 1.0–2.9]), whereas other CVB types did not differ between the groups. CVB1-associated risk was not related to HLA genotype, age, or sex. Finnish children had a lower frequency of CVB antibodies than children in other countries. The results support previous studies that suggested an association between CVBs and type 1 diabetes, highlighting the possible role of CVB1 as a diabetogenic virus type.

  • Received April 18, 2013.
  • Accepted August 1, 2013.
  • © 2014 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes
Sami Oikarinen, Sisko Tauriainen, Didier Hober, Bernadette Lucas, Andriani Vazeou, Amirbabak Sioofy-Khojine, Evangelos Bozas, Peter Muir, Hanna Honkanen, Jorma Ilonen, Mikael Knip, Päivi Keskinen, Marja-Terttu Saha, Heini Huhtala, Glyn Stanway, Christos Bartsocas, Johnny Ludvigsson, Keith Taylor, Heikki Hyöty, the VirDiab Study Group
Diabetes Feb 2014, 63 (2) 655-662; DOI: 10.2337/db13-0620

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Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes
Sami Oikarinen, Sisko Tauriainen, Didier Hober, Bernadette Lucas, Andriani Vazeou, Amirbabak Sioofy-Khojine, Evangelos Bozas, Peter Muir, Hanna Honkanen, Jorma Ilonen, Mikael Knip, Päivi Keskinen, Marja-Terttu Saha, Heini Huhtala, Glyn Stanway, Christos Bartsocas, Johnny Ludvigsson, Keith Taylor, Heikki Hyöty, the VirDiab Study Group
Diabetes Feb 2014, 63 (2) 655-662; DOI: 10.2337/db13-0620
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