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Table of Contents

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April 01 2014; volume 63 issue 4

In This Issue

  • Open Access
    In This Issue of Diabetes
    Diabetes 2014 Apr; 63 (4): 1167-1168. https://doi.org/10.2337/db14-ti04
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Editors’ Commentary

  • Open Access
    Time to Look Back and to Look Forward
    K. Sreekumaran Nair, E. Dale Abel, Sharon G. Adler, Peter J. Dyck, Thomas W. Gardner, Kathryn M. Haskins, Gökhan Hotamisligil, Michael D. Jensen, Anna Krook, Lawrence J. Mandarino, Braxton D. Mitchell, Jeffrey E. Pessin, James R. Sowers, Lori Sussel, Nick Wareham and Adrian Vella
    Diabetes 2014 Apr; 63 (4): 1169-1170. https://doi.org/10.2337/db14-0067
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Commentaries

  • Open Access
    Effects of Roux-en-Y Gastric Bypass on β-Cell Function
    Ram Weiss
    Diabetes 2014 Apr; 63 (4): 1171-1173. https://doi.org/10.2337/db13-1897
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  • Open Access
    Incretin Therapy and Pancreatic Pathologies: Background Pathology Versus Drug-Induced Pathology in Rats
    Josephine M. Egan and Chee W. Chia
    Diabetes 2014 Apr; 63 (4): 1174-1178. https://doi.org/10.2337/db13-1909
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  • Open Access
    Tipping the Balance in Metabolic Regulation: Regulating Regulatory T Cells by Costimulation
    Ling Qi
    Diabetes 2014 Apr; 63 (4): 1179-1181. https://doi.org/10.2337/db13-1915
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  • Open Access
    Tissue-Specific Expression of GLP1R in Mice: Is the Problem of Antibody Nonspecificity Solved?
    Annayya Aroor and Ravi Nistala
    Diabetes 2014 Apr; 63 (4): 1182-1184. https://doi.org/10.2337/db13-1937
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  • Open Access
    Diabetes Gets on the Nerves of the Bone Marrow Niche
    Annarosa Leri and Marcello Rota
    Diabetes 2014 Apr; 63 (4): 1185-1187. https://doi.org/10.2337/db13-1931
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  • Open Access
    Using Oral Challenge Testing to Assess Insulin Action and Secretion With Mathematical Modeling
    Myrlene A. Staten and David E. Kelley
    Diabetes 2014 Apr; 63 (4): 1188-1190. https://doi.org/10.2337/db13-1839
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  • Open Access
    Deoxysphingolipids: β-Cell, Beware of These New Kids on the Block
    Anjaneyulu Kowluru
    Diabetes 2014 Apr; 63 (4): 1191-1193. https://doi.org/10.2337/db14-0022
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  • Open Access
    Glycogen Synthase Kinase-3β and Cathepsin B in Diabetic Endothelial Progenitor Cell Dysfunction: An Old Player Finds a New Partner
    Ranganath Muniyappa and James R. Sowers
    Diabetes 2014 Apr; 63 (4): 1194-1197. https://doi.org/10.2337/db14-0004
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  • Open Access
    Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in β-Cell Regeneration Research
    Andrew F. Stewart
    Diabetes 2014 Apr; 63 (4): 1198-1199. https://doi.org/10.2337/db14-0009
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  • Open Access
    A Radical Concept on Caveolae and Endothelial Dysfunction in Coronary Microvascular Disease in Diabetes
    Erik J. Henriksen
    Diabetes 2014 Apr; 63 (4): 1200-1202. https://doi.org/10.2337/db14-0057
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Methodology Review

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    The Oral Minimal Model Method
    Claudio Cobelli, Chiara Dalla Man, Gianna Toffolo, Rita Basu, Adrian Vella and Robert Rizza
    Diabetes 2014 Apr; 63 (4): 1203-1213. https://doi.org/10.2337/db13-1198
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Metabolism

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    Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission
    Roxanne Dutia, Katrina Brakoniecki, Phoebe Bunker, Furcy Paultre, Peter Homel, André C. Carpentier, James McGinty and Blandine Laferrère
    Diabetes 2014 Apr; 63 (4): 1214-1223. https://doi.org/10.2337/db13-1176
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    Identification and Characterization of GLP-1 Receptor–Expressing Cells Using a New Transgenic Mouse Model
    Paul Richards, Helen E. Parker, Alice E. Adriaenssens, Joshua M. Hodgson, Simon C. Cork, Stefan Trapp, Fiona M. Gribble and Frank Reimann
    Diabetes 2014 Apr; 63 (4): 1224-1233. https://doi.org/10.2337/db13-1440
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    Hypothalamic Nesfatin-1/NUCB2 Knockdown Augments Hepatic Gluconeogenesis That Is Correlated With Inhibition of mTOR-STAT3 Signaling Pathway in Rats
    Dandong Wu, Mengliu Yang, Yang Chen, Yanjun Jia, Zhongmin Alex Ma, Guenther Boden, Ling Li and Gangyi Yang
    Diabetes 2014 Apr; 63 (4): 1234-1247. https://doi.org/10.2337/db13-0899
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    Additive Effects of MicroRNAs and Transcription Factors on CCL2 Production in Human White Adipose Tissue
    Agné Kulyté, Yasmina Belarbi, Silvia Lorente-Cebrián, Clara Bambace, Erik Arner, Carsten O. Daub, Per Hedén, Mikael Rydén, Niklas Mejhert and Peter Arner
    Diabetes 2014 Apr; 63 (4): 1248-1258. https://doi.org/10.2337/db13-0702
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    Regulation of Hypothalamic Neuronal Sensing and Food Intake by Ketone Bodies and Fatty Acids
    Christelle Le Foll, Ambrose A. Dunn-Meynell, Henri M. Miziorko and Barry E. Levin
    Diabetes 2014 Apr; 63 (4): 1259-1269. https://doi.org/10.2337/db13-1090
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Obesity Studies

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    Obesity-Induced Infertility and Hyperandrogenism Are Corrected by Deletion of the Insulin Receptor in the Ovarian Theca Cell
    Sheng Wu, Sara Divall, Amanda Nwaopara, Sally Radovick, Fredric Wondisford, CheMyong Ko and Andrew Wolfe
    Diabetes 2014 Apr; 63 (4): 1270-1282. https://doi.org/10.2337/db13-1514
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Islet Studies

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    Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting
    Yang Jiao, John Le Lay, Ming Yu, Ali Naji and Klaus H. Kaestner
    Diabetes 2014 Apr; 63 (4): 1283-1288. https://doi.org/10.2337/db13-1435
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Immunology and Transplantation

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    T-Cell Costimulation Protects Obesity-Induced Adipose Inflammation and Insulin Resistance
    Jixin Zhong, Xiaoquan Rao, Zachary Braunstein, Anne Taylor, Vimal Narula, Jeffrey Hazey, Dean Mikami, Bradley Needleman, Jessica Rutsky, Qinghua Sun, Jeffrey A. Deiuliis, Abhay R. Satoskar and Sanjay Rajagopalan
    Diabetes 2014 Apr; 63 (4): 1289-1302. https://doi.org/10.2337/db13-1094
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Pathophysiology

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    Occurrence of Spontaneous Pancreatic Lesions in Normal and Diabetic Rats: A Potential Confounding Factor in the Nonclinical Assessment of GLP-1–Based Therapies
    Kristina D. Chadwick, Anthony M. Fletcher, M. Cecilia Parrula, Susan Bonner-Weir, Raja S. Mangipudy, Evan Janovitz, Michael J. Graziano, Denis Roy and Timothy P. Reilly
    Diabetes 2014 Apr; 63 (4): 1303-1314. https://doi.org/10.2337/db13-1268
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    KCNQ1 Long QT Syndrome Patients Have Hyperinsulinemia and Symptomatic Hypoglycemia
    Signe S. Torekov, Eva Iepsen, Michael Christiansen, Allan Linneberg, Oluf Pedersen, Jens J. Holst, Jørgen K. Kanters and Torben Hansen
    Diabetes 2014 Apr; 63 (4): 1315-1325. https://doi.org/10.2337/db13-1454
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    Deoxysphingolipids, Novel Biomarkers for Type 2 Diabetes, Are Cytotoxic for Insulin-Producing Cells
    Richard A. Zuellig, Thorsten Hornemann, Alaa Othman, Adrian B. Hehl, Heiko Bode, Tanja Güntert, Omolara O. Ogunshola, Enrica Saponara, Kamile Grabliauskaite, Jae-Hwi Jang, Udo Ungethuem, Yu Wei, Arnold von Eckardstein, Rolf Graf and Sabrina Sonda
    Diabetes 2014 Apr; 63 (4): 1326-1339. https://doi.org/10.2337/db13-1042
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    Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation
    Guo-Xiao Wang, Kae Won Cho, Maeran Uhm, Chun-Rui Hu, Siming Li, Zoharit Cozacov, Acer E. Xu, Ji-Xin Cheng, Alan R. Saltiel, Carey N. Lumeng and Jiandie D. Lin
    Diabetes 2014 Apr; 63 (4): 1340-1352. https://doi.org/10.2337/db13-1139
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Complications

  • You have accessRestricted Access
    Diabetes Causes Bone Marrow Autonomic Neuropathy and Impairs Stem Cell Mobilization via Dysregulated p66Shc and Sirt1
    Mattia Albiero, Nicol Poncina, Marc Tjwa, Stefano Ciciliot, Lisa Menegazzo, Giulio Ceolotto, Saula Vigili de Kreutzenberg, Rute Moura, Marco Giorgio, Piergiuseppe Pelicci, Angelo Avogaro and Gian Paolo Fadini
    Diabetes 2014 Apr; 63 (4): 1353-1365. https://doi.org/10.2337/db13-0894
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    Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy
    Li Xiao, Xuejing Zhu, Shikun Yang, Fuyou Liu, Zhiguang Zhou, Ming Zhan, Ping Xie, Dongshan Zhang, Jun Li, Panai Song, Yashpal S. Kanwar and Lin Sun
    Diabetes 2014 Apr; 63 (4): 1366-1380. https://doi.org/10.2337/db13-1412
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    Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients
    James Cassuto, Huijuan Dou, Istvan Czikora, Andras Szabo, Vijay S. Patel, Vinayak Kamath, Eric Belin de Chantemele, Attila Feher, Maritza J. Romero and Zsolt Bagi
    Diabetes 2014 Apr; 63 (4): 1381-1393. https://doi.org/10.2337/db13-0577
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Pharmacology and Therapeutics

  • You have accessRestricted Access
    Identification of a Small Molecular Insulin Receptor Agonist With Potent Antidiabetes Activity
    Guifen Qiang, Shenghui Xue, Jenny J. Yang, Guanhua Du, Xiaobin Pang, Xiaoting Li, Devrishi Goswami, Patrick R. Griffin, Eric A. Ortlund, Chi Bun Chan and Keqiang Ye
    Diabetes 2014 Apr; 63 (4): 1394-1409. https://doi.org/10.2337/db13-0334
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    Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality via Cathepsin B: A Novel Therapeutic Opportunity for Arterial Repair
    Benjamin Hibbert, Jessie R. Lavoie, Xiaoli Ma, Tara Seibert, Joshua E. Raizman, Trevor Simard, Yong-Xiang Chen, Duncan Stewart and Edward R. O’Brien
    Diabetes 2014 Apr; 63 (4): 1410-1421. https://doi.org/10.2337/db13-0941
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    GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet
    Christoffer Clemmensen, Joseph Chabenne, Brian Finan, Lorraine Sullivan, Katrin Fischer, Daniela Küchler, Laura Sehrer, Teja Ograjsek, Susanna M. Hofmann, Sonja C. Schriever, Paul T. Pfluger, Jason Pinkstaff, Matthias H. Tschöp, Richard DiMarchi and Timo D. Müller
    Diabetes 2014 Apr; 63 (4): 1422-1427. https://doi.org/10.2337/db13-1609
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Erratum

  • Open Access
    Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome. Diabetes 2013;62:1084–1093
    Carlos Escande, Veronica Nin, Nathan L. Price, Verena Capellini, Ana P. Gomes, Maria Thereza Barbosa, Luke O’Neil, Thomas A. White, David A. Sinclair and Eduardo N. Chini
    Diabetes 2014 Apr; 63 (4): 1428. https://doi.org/10.2337/db14-er04
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Issues and Events

  • Open Access
    Issues and Events
    Diabetes 2014 Apr; 63 (4): 1429. https://doi.org/10.2337/db14-ie04
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Online Letters: Comments and Responses

  • Open Access
    Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922
    Stefanie Lieske and Andreas L. Birkenfeld
    Diabetes 2014 Apr; 63 (4): e1. https://doi.org/10.2337/db13-1844
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  • Open Access
    Response to Comment on Boden et al. Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue. Diabetes 2014;63:912–922
    Guenther Boden, Peter Cheung, Sajad Salehi, Carol Homko, Catherine Loveland-Jones, Senthil Jayarajan, T. Peter Stein, Carlos A. Barrero, Salim Merali, Kevin Jon Williams and Ming-Lin Liu
    Diabetes 2014 Apr; 63 (4): e2. https://doi.org/10.2337/db13-1906
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  • Open Access
    Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223
    Antonio E. Pontiroli
    Diabetes 2014 Apr; 63 (4): e3. https://doi.org/10.2337/db13-1924
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  • Open Access
    Response to Comment on Dutia et al. Limited Recovery of β-Cell Function After Gastric Bypass Despite Clinical Diabetes Remission. Diabetes 2014;63:1214−1223
    Roxanne Dutia, Katrina Brakoniecki, Phoebe Bunker, Furcy Paultre, Peter Homel, André C. Carpentier, James McGinty and Blandine Laferrère
    Diabetes 2014 Apr; 63 (4): e4. https://doi.org/10.2337/db14-0112
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Diabetes: 63 (4)

In this Issue

April 2014, 63(4)
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