A Radical Concept on Caveolae and Endothelial Dysfunction in Coronary Microvascular Disease in Diabetes

The impact of OONO⁻ on the regulation of coronary microcirculation in conditions of diabetes. The figure illustrates the key concepts of the study of Cassuto et al. (11), indicating how elevated OONO⁻ levels can impair the expression and proper assembly of endothelial caveolae, leading to dysregulation of NO-dependent FMD in coronary arterioles, thereby increasing the risk of coronary microcirculatory disease in humans with type 1 or 2 diabetes.