A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

Genetics/Genomes/Proteomics/Metabolomics

¹JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U.K.
²Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, U.K.
³The Australian E-Health Research Centre, Royal Brisbane and Women’s Hospital, Queensland, Australia
⁴The Commonwealth Scientific and Industrial Research Organisation (CSIRO) Preventative Health Flagship, Victoria, Australia
⁵CSIRO Mathematics and Information Sciences, Macquarie University, New South Wales, Australia
⁶Institute of Diabetes Research, Helmholtz Zentrum München, Neuherberg, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, München, Germany
⁷Department of Paediatrics, School of Clinical Medicine, University of Cambridge, Cambridge, U.K.
⁸CRTD-DFG Research Center for Regenerative Therapies Dresden and Paul Langerhans Institute Dresden, Technische Universität Dresden, Dresden, Germany

Corresponding authors: John A. Todd, john.todd{at}cimr.cam.ac.uk; Chris Wallace, chris.wallace{at}cimr.cam.ac.uk; or Anette-G. Ziegler, anette-g.ziegler{at}helmholtz-muenchen.de.