On the cover: A polarized light micrograph of metformin crystals. This issue features two articles on the genetic determinants of metformin response, “Metformin Pharmacogenomics: Current Status and Future Directions” by Pawlyk et al. (p. 2590) and “Metformin Pharmacogenomics: Biomarkers to Mechanisms” by Wang and Weinshilboum (p. 2609). Photo credit: Antonio Romero/Science Source, www.sciencesource.com.


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