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Table of Contents

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September 01 2014; volume 63 issue 9

In This Issue

  • Open Access
    In This Issue of Diabetes
    Diabetes 2014 Sep; 63 (9): 2899-2900. https://doi.org/10.2337/db14-ti09
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Commentaries

  • Open Access
    Integrating Transcriptome and Epigenome: Putting Together the Pieces of the Type 2 Diabetes Pathogenesis Puzzle
    Swapan Kumar Das
    Diabetes 2014 Sep; 63 (9): 2901-2903. https://doi.org/10.2337/db14-0757
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  • Open Access
    Is There a Sweet Spot for Nrf2 Activation in the Treatment of Diabetic Kidney Disease?
    Evan T. Hall and Vivek Bhalla
    Diabetes 2014 Sep; 63 (9): 2904-2905. https://doi.org/10.2337/db14-0829
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  • Open Access
    Role for Tet in Hyperglycemia-Induced Demethylation: A Novel Mechanism of Diabetic Metabolic Memory
    Guo-Lian Ding and He-Feng Huang
    Diabetes 2014 Sep; 63 (9): 2906-2908. https://doi.org/10.2337/db14-0675
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  • Open Access
    Visual Fields Refine Understanding of Diabetic Retinopathy Progression
    Gregory R. Jackson and Thomas W. Gardner
    Diabetes 2014 Sep; 63 (9): 2909-2910. https://doi.org/10.2337/db14-0741
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Metabolism

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    I Prostanoid Receptor–Mediated Inflammatory Pathway Promotes Hepatic Gluconeogenesis Through Activation of PKA and Inhibition of AKT
    Shuai Yan, Qianqian Zhang, Xiaojing Zhong, Juan Tang, Yuanyang Wang, Junjie Yu, Yi Zhou, Jian Zhang, Feifan Guo, Yi Liu, Garret A. FitzGerald and Ying Yu
    Diabetes 2014 Sep; 63 (9): 2911-2923. https://doi.org/10.2337/db13-1893
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    Mitogen-Activated Protein Kinase Phosphatase 3 (MKP-3)–Deficient Mice Are Resistant to Diet-Induced Obesity
    Bin Feng, Ping Jiao, Ynes Helou, Yujie Li, Qin He, Matthew S. Walters, Arthur Salomon and Haiyan Xu
    Diabetes 2014 Sep; 63 (9): 2924-2934. https://doi.org/10.2337/db14-0066
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    Metabolic Crosstalk: Molecular Links Between Glycogen and Lipid Metabolism in Obesity
    Binbin Lu, Dave Bridges, Yemen Yang, Kaleigh Fisher, Alan Cheng, Louise Chang, Zhuo-Xian Meng, Jiandie D. Lin, Michael Downes, Ruth T. Yu, Christopher Liddle, Ronald M. Evans and Alan R. Saltiel
    Diabetes 2014 Sep; 63 (9): 2935-2948. https://doi.org/10.2337/db13-1531
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    KSRP Ablation Enhances Brown Fat Gene Program in White Adipose Tissue Through Reduced miR-150 Expression
    Chu-Fang Chou, Yi-Yu Lin, Hsu-Kun Wang, Xiaolin Zhu, Matteo Giovarelli, Paola Briata, Roberto Gherzi, W. Timothy Garvey and Ching-Yi Chen
    Diabetes 2014 Sep; 63 (9): 2949-2961. https://doi.org/10.2337/db13-1901
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    Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
    Emma Nilsson, Per Anders Jansson, Alexander Perfilyev, Petr Volkov, Maria Pedersen, Maria K. Svensson, Pernille Poulsen, Rasmus Ribel-Madsen, Nancy L. Pedersen, Peter Almgren, João Fadista, Tina Rönn, Bente Klarlund Pedersen, Camilla Scheele, Allan Vaag and Charlotte Ling
    Diabetes 2014 Sep; 63 (9): 2962-2976. https://doi.org/10.2337/db13-1459
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    Insulin Resistance Is Associated With Diminished Endoplasmic Reticulum Stress Responses in Adipose Tissue of Healthy and Diabetic Subjects
    Guenther Boden, Peter Cheung, Karen Kresge, Carol Homko, Ben Powers and Lucas Ferrer
    Diabetes 2014 Sep; 63 (9): 2977-2983. https://doi.org/10.2337/db14-0055
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Islet Studies

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    Glycoprotein 130 Receptor Signaling Mediates α-Cell Dysfunction in a Rodent Model of Type 2 Diabetes
    Samuel Z. Chow, Madeleine Speck, Piriya Yoganathan, Dominika Nackiewicz, Ann Maria Hansen, Mette Ladefoged, Björn Rabe, Stefan Rose-John, Peter J. Voshol, Francis C. Lynn, Pedro L. Herrera, Werner Müller, Helga Ellingsgaard and Jan A. Ehses
    Diabetes 2014 Sep; 63 (9): 2984-2995. https://doi.org/10.2337/db13-1121
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    Pancreatic β-Cell Failure Mediated by mTORC1 Hyperactivity and Autophagic Impairment
    Alberto Bartolomé, Maki Kimura-Koyanagi, Shun-Ichiro Asahara, Carlos Guillén, Hiroyuki Inoue, Kyoko Teruyama, Shinobu Shimizu, Ayumi Kanno, Ana García-Aguilar, Masato Koike, Yasuo Uchiyama, Manuel Benito, Tetsuo Noda and Yoshiaki Kido
    Diabetes 2014 Sep; 63 (9): 2996-3008. https://doi.org/10.2337/db13-0970
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    ADCY5 Couples Glucose to Insulin Secretion in Human Islets
    David J. Hodson, Ryan K. Mitchell, Lorella Marselli, Timothy J. Pullen, Silvia Gimeno Brias, Francesca Semplici, Katy L. Everett, Dermot M.F. Cooper, Marco Bugliani, Piero Marchetti, Vanessa Lavallard, Domenico Bosco, Lorenzo Piemonti, Paul R. Johnson, Stephen J. Hughes, Daliang Li, Wen-Hong Li, A.M. James Shapiro and Guy A. Rutter
    Diabetes 2014 Sep; 63 (9): 3009-3021. https://doi.org/10.2337/db13-1607
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Immunology and Transplantation

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    Identification of Novel Autoantibodies in Type 1 Diabetic Patients Using a High-Density Protein Microarray
    Bo Kyung Koo, Sehyun Chae, Kristine M. Kim, Min Jueng Kang, Eunhee G. Kim, Soo Heon Kwak, Hye Seung Jung, Young Min Cho, Sung Hee Choi, Young Joo Park, Choong Ho Shin, Hak C. Jang, Chan Soo Shin, Daehee Hwang, Eugene C. Yi and Kyong Soo Park
    Diabetes 2014 Sep; 63 (9): 3022-3032. https://doi.org/10.2337/db13-1566
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    Recognition of Posttranslationally Modified GAD65 Epitopes in Subjects With Type 1 Diabetes
    John W. McGinty, I-Ting Chow, Carla Greenbaum, Jared Odegard, William W. Kwok and Eddie A. James
    Diabetes 2014 Sep; 63 (9): 3033-3040. https://doi.org/10.2337/db13-1952
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    Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis
    Francesca D’Addio, Alessandro Valderrama Vasquez, Moufida Ben Nasr, Edward Franek, Dalong Zhu, Lirong Li, Guang Ning, Emilian Snarski and Paolo Fiorina
    Diabetes 2014 Sep; 63 (9): 3041-3046. https://doi.org/10.2337/db14-0295
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Pathophysiology

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    Diabetes Irreversibly Depletes Bone Marrow–Derived Mesenchymal Progenitor Cell Subpopulations
    Michael Januszyk, Michael Sorkin, Jason P. Glotzbach, Ivan N. Vial, Zeshaan N. Maan, Robert C. Rennert, Dominik Duscher, Hariharan Thangarajah, Michael T. Longaker, Atul J. Butte and Geoffrey C. Gurtner
    Diabetes 2014 Sep; 63 (9): 3047-3056. https://doi.org/10.2337/db13-1366
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Complications

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    Angiopoietin 2 Induces Pericyte Apoptosis via α3β1 Integrin Signaling in Diabetic Retinopathy
    Sung Wook Park, Jang-Hyuk Yun, Jin Hyoung Kim, Kyu-Won Kim, Chung-Hyun Cho and Jeong Hun Kim
    Diabetes 2014 Sep; 63 (9): 3057-3068. https://doi.org/10.2337/db13-1942
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    Parp Inhibition Prevents Ten-Eleven Translocase Enzyme Activation and Hyperglycemia-Induced DNA Demethylation
    Nyembezi Dhliwayo, Michael P. Sarras, Ernest Luczkowski, Samantha M. Mason and Robert V. Intine
    Diabetes 2014 Sep; 63 (9): 3069-3076. https://doi.org/10.2337/db13-1916
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    mTORC1-Independent Reduction of Retinal Protein Synthesis in Type 1 Diabetes
    Patrice E. Fort, Mandy K. Losiewicz, Subramaniam Pennathur, Leonard S. Jefferson, Scot R. Kimball, Steven F. Abcouwer and Thomas W. Gardner
    Diabetes 2014 Sep; 63 (9): 3077-3090. https://doi.org/10.2337/db14-0235
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    Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease
    Sih Min Tan, Arpeeta Sharma, Nada Stefanovic, Derek Y.C. Yuen, Tom C. Karagiannis, Colin Meyer, Keith W. Ward, Mark E. Cooper and Judy B. de Haan
    Diabetes 2014 Sep; 63 (9): 3091-3103. https://doi.org/10.2337/db13-1743
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    Progression of Early Retinal Dysfunction in Diabetes Over Time: Results of a Long-term Prospective Clinical Study
    Karl-Johan Hellgren, Elisabet Agardh and Boel Bengtsson
    Diabetes 2014 Sep; 63 (9): 3104-3111. https://doi.org/10.2337/db13-1628
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    Task-Induced Brain Activity Patterns in Type 2 Diabetes: A Potential Biomarker for Cognitive Decline
    Thomas J. Marder, Veronica L. Flores, Nicolas R. Bolo, Wouter S. Hoogenboom, Donald C. Simonson, Alan M. Jacobson, Sarah E. Foote, Martha E. Shenton, Reisa A. Sperling and Gail Musen
    Diabetes 2014 Sep; 63 (9): 3112-3119. https://doi.org/10.2337/db13-1783
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Pharmacology and Therapeutics

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    Recommendations for the Definition of Clinical Responder in Insulin Preservation Studies
    Craig A. Beam, Stephen E. Gitelman, Jerry P. Palmer and the Type 1 Diabetes TrialNet Study Group
    Diabetes 2014 Sep; 63 (9): 3120-3127. https://doi.org/10.2337/db14-0095
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    Combined Therapy With GABA and Proinsulin/Alum Acts Synergistically to Restore Long-term Normoglycemia by Modulating T-Cell Autoimmunity and Promoting β-Cell Replication in Newly Diabetic NOD Mice
    Jide Tian, Hoa Dang, An Viet Nguyen, Zheying Chen and Daniel L. Kaufman
    Diabetes 2014 Sep; 63 (9): 3128-3134. https://doi.org/10.2337/db13-1385
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Genetics/Genomes/Proteomics/Metabolomics

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    IRS1 G972R Missense Polymorphism Is Associated With Failure to Oral Antidiabetes Drugs in White Patients With Type 2 Diabetes From Italy
    Sabrina Prudente, Eleonora Morini, Daniela Lucchesi, Olga Lamacchia, Diego Bailetti, Luana Mercuri, Federica Alberico, Massimiliano Copetti, Laura Pucci, Stefania Fariello, Laura Giusti, Mauro Cignarelli, Giuseppe Penno, Salvatore De Cosmo and Vincenzo Trischitta
    Diabetes 2014 Sep; 63 (9): 3135-3140. https://doi.org/10.2337/db13-1966
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    MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes
    C. Lisa Kurtz, Bailey C.E. Peck, Emily E. Fannin, Carine Beysen, Ji Miao, Stuart R. Landstreet, Shengli Ding, Vandana Turaga, P. Kay Lund, Scott Turner, Sudha B. Biddinger, Kasey C. Vickers and Praveen Sethupathy
    Diabetes 2014 Sep; 63 (9): 3141-3148. https://doi.org/10.2337/db13-1015
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    Pleiotropic Effects of Lipid Genes on Plasma Glucose, HbA1c, and HOMA-IR Levels
    Naishi Li, Marijke R. van der Sijde, LifeLines Cohort Study Group, Stephan J.L. Bakker, Robin P.F. Dullaart, Pim van der Harst, Ron T. Gansevoort, Clara C. Elbers, Cisca Wijmenga, Harold Snieder, Marten H. Hofker and Jingyuan Fu
    Diabetes 2014 Sep; 63 (9): 3149-3158. https://doi.org/10.2337/db13-1800
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Addendum

  • Open Access
    GLUT4 and Glycogen Synthase Are Key Players in Bed Rest–Induced Insulin Resistance. Diabetes 2012;61:1090—1099
    Rasmus S. Biensø, Stine Ringholm, Kristian Kiilerich, Niels-Jacob Aachmann-Andersen, Rikke Krogh-Madsen, Borja Guerra, Peter Plomgaard, Gerrit van Hall, Jonas T. Treebak, Bengt Saltin, Carsten Lundby, Jose A.L. Calbet, Henriette Pilegaard and Jørgen F.P. Wojtaszewski
    Diabetes 2014 Sep; 63 (9): 3159. https://doi.org/10.2337/db14-ad09
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Issues and Events

  • Open Access
    Issues and Events
    Diabetes 2014 Sep; 63 (9): 3160. https://doi.org/10.2337/db14-ie09
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e-Letters: Comments and Responses

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    Comment on Wu and Spiegelman. Irisin ERKs the Fat. Diabetes 2014;63:381−383
    Manuela Elsen, Silja Raschke, Mark Sommerfeld, Hans Gassenhuber and Jürgen Eckel
    Diabetes 2014 Sep; 63 (9): e16. https://doi.org/10.2337/db14-0776
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    Response to Comment on Wu and Spiegelman. Irisin ERKs the Fat. Diabetes 2014;63:381−383
    Bruce M. Spiegelman and Christiane Wrann
    Diabetes 2014 Sep; 63 (9): e17. https://doi.org/10.2337/db14-0898
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    Comment on Fabbrini et al. Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. Diabetes 2014;63:976−981
    Eric E. Kelley
    Diabetes 2014 Sep; 63 (9): e18. https://doi.org/10.2337/db14-0740
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    Response to Comment on Fabbrini et al. Effect of Plasma Uric Acid on Antioxidant Capacity, Oxidative Stress, and Insulin Sensitivity in Obese Subjects. Diabetes 2014;63:976−981
    Elisa Fabbrini, Mauro Serafini and Samuel Klein
    Diabetes 2014 Sep; 63 (9): e19. https://doi.org/10.2337/db14-0885
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Diabetes: 63 (9)

In this Issue

September 2014, 63(9)
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