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Table of Contents

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October 01 2015; volume 64 issue 10

In This Issue

  • Open Access
    In This Issue of Diabetes
    Diabetes 2015 Oct; 64 (10): 3337-3338. https://doi.org/10.2337/db15-ti10
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Commentaries

  • Open Access
    Unsticking the Broken Diabetic Heart: O-GlcNAcylation and Calcium Sensitivity
    Adam R. Wende
    Diabetes 2015 Oct; 64 (10): 3339-3341. https://doi.org/10.2337/dbi15-0001
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  • Open Access
    Defective Wnt Signaling: A Potential Contributor to Cardiometabolic Disease?
    Amy C. Arnold and David Robertson
    Diabetes 2015 Oct; 64 (10): 3342-3344. https://doi.org/10.2337/db15-0822
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  • Open Access
    Paying the Toll for Glucose Regulation: A Central Role for TLR3
    Matthew D. Woolard and Christopher G. Kevil
    Diabetes 2015 Oct; 64 (10): 3345-3346. https://doi.org/10.2337/db15-0679
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  • Open Access
    Alternative Approach to Immunomodulation for Type 1 Diabetes: Antigen-Specific Immunotherapy In Utero
    Parth Narendran
    Diabetes 2015 Oct; 64 (10): 3347-3349. https://doi.org/10.2337/db15-0825
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  • Open Access
    Kallikrein-Kinin System: An Emerging Competitor or Collaborator for VEGF in Diabetic Macular Edema?
    Tomoaki Murakami
    Diabetes 2015 Oct; 64 (10): 3350-3352. https://doi.org/10.2337/db15-0746
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  • Open Access
    Too Much or Too Little? The Double Jeopardy of Subcutaneous Insulin Therapy in Diabetes
    Mark L. Evans
    Diabetes 2015 Oct; 64 (10): 3353-3354. https://doi.org/10.2337/dbi15-0003
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Metabolism

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    Inactivation of NF-κB p65 (RelA) in Liver Improves Insulin Sensitivity and Inhibits cAMP/PKA Pathway
    Bilun Ke, Zhiyun Zhao, Xin Ye, Zhanguo Gao, Vincent Manganiello, Bin Wu and Jianping Ye
    Diabetes 2015 Oct; 64 (10): 3355-3362. https://doi.org/10.2337/db15-0242
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    Fasting-Induced Lipolysis and Hypothalamic Insulin Signaling Are Regulated by Neuronal Glucosylceramide Synthase
    Silke Herzer, Sascha Meldner, Hermann-Josef Gröne and Viola Nordström
    Diabetes 2015 Oct; 64 (10): 3363-3376. https://doi.org/10.2337/db14-1726
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    Increased Bile Acid Synthesis and Deconjugation After Biliopancreatic Diversion
    Ele Ferrannini, Stefania Camastra, Brenno Astiarraga, Monica Nannipieri, Jose Castro-Perez, Dan Xie, Liangsu Wang, Manu Chakravarthy and Rebecca A. Haeusler
    Diabetes 2015 Oct; 64 (10): 3377-3385. https://doi.org/10.2337/db15-0214
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    Increased Skeletal Muscle Capillarization Independently Enhances Insulin Sensitivity in Older Adults After Exercise Training and Detraining
    Steven J. Prior, Andrew P. Goldberg, Heidi K. Ortmeyer, Eva R. Chin, Dapeng Chen, Jacob B. Blumenthal and Alice S. Ryan
    Diabetes 2015 Oct; 64 (10): 3386-3395. https://doi.org/10.2337/db14-1771
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    Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity
    Lale Ozcan, Xiaoming Xu, Shi-Xian Deng, Devram S. Ghorpade, Tiffany Thomas, Serge Cremers, Brian Hubbard, Michael H. Serrano-Wu, Matthias Gaestel, Donald W. Landry and Ira Tabas
    Diabetes 2015 Oct; 64 (10): 3396-3405. https://doi.org/10.2337/db14-1945
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    Exenatide Regulates Cerebral Glucose Metabolism in Brain Areas Associated With Glucose Homeostasis and Reward System
    Giuseppe Daniele, Patricia Iozzo, Marjorie Molina-Carrion, Jack Lancaster, Demetrio Ciociaro, Eugenio Cersosimo, Devjit Tripathy, Curtis Triplitt, Peter Fox, Nicolas Musi, Ralph DeFronzo and Amalia Gastaldelli
    Diabetes 2015 Oct; 64 (10): 3406-3412. https://doi.org/10.2337/db14-1718
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    Wnt Signaling Regulates Blood Pressure by Downregulating a GSK-3β–Mediated Pathway to Enhance Insulin Signaling in the Central Nervous System
    Pei-Wen Cheng, Ying-Ying Chen, Wen-Han Cheng, Pei-Jung Lu, Hsin-Hung Chen, Bo-Rong Chen, Tung-Chen Yeh, Gwo-Ching Sun, Michael Hsiao and Ching-Jiunn Tseng
    Diabetes 2015 Oct; 64 (10): 3413-3424. https://doi.org/10.2337/db14-1439
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    Toll-Like Receptor 3 Influences Glucose Homeostasis and β-Cell Insulin Secretion
    Daniela Strodthoff, Zuheng Ma, Tina Wirström, Rona J. Strawbridge, Daniel F.J. Ketelhuth, David Engel, Robert Clarke, Sture Falkmer, Anders Hamsten, Göran K. Hansson, Anneli Björklund and Anna M. Lundberg
    Diabetes 2015 Oct; 64 (10): 3425-3438. https://doi.org/10.2337/db14-0838
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    Insulin Delivery Into the Peripheral Circulation: A Key Contributor to Hypoglycemia in Type 1 Diabetes
    Justin M. Gregory, Guillaume Kraft, Melanie F. Scott, Doss W. Neal, Ben Farmer, Marta S. Smith, Jon R. Hastings, Eric J. Allen, E. Patrick Donahue, Noelia Rivera, Jason J. Winnick, Dale S. Edgerton, Erica Nishimura, Christian Fledelius, Christian L. Brand and Alan D. Cherrington
    Diabetes 2015 Oct; 64 (10): 3439-3451. https://doi.org/10.2337/db15-0071
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Obesity Studies

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    DAPK2 Downregulation Associates With Attenuated Adipocyte Autophagic Clearance in Human Obesity
    Hedi Soussi, Sophie Reggio, Rohia Alili, Cecilia Prado, Sonia Mutel, Maria Pini, Christine Rouault, Karine Clément and Isabelle Dugail
    Diabetes 2015 Oct; 64 (10): 3452-3463. https://doi.org/10.2337/db14-1933
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    Alterations of a Cellular Cholesterol Metabolism Network Are a Molecular Feature of Obesity-Related Type 2 Diabetes and Cardiovascular Disease
    Jingzhong Ding, Lindsay M. Reynolds, Tanja Zeller, Christian Müller, Kurt Lohman, Barbara J. Nicklas, Stephen B. Kritchevsky, Zhiqing Huang, Alberto de la Fuente, Nicola Soranzo, Robert E. Settlage, Chia-Chi Chuang, Timothy Howard, Ning Xu, Mark O. Goodarzi, Y.-D. Ida Chen, Jerome I. Rotter, David S. Siscovick, John S. Parks, Susan Murphy, David R. Jacobs, Wendy Post, Russell P. Tracy, Philipp S. Wild, Stefan Blankenberg, Ina Hoeschele, David Herrington, Charles E. McCall and Yongmei Liu
    Diabetes 2015 Oct; 64 (10): 3464-3474. https://doi.org/10.2337/db14-1314
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Islet Studies

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    Diabetes Susceptibility Genes Pdx1 and Clec16a Function in a Pathway Regulating Mitophagy in β-Cells
    Scott A. Soleimanpour, Alana M. Ferrari, Jeffrey C. Raum, David N. Groff, Juxiang Yang, Brett A. Kaufman and Doris A. Stoffers
    Diabetes 2015 Oct; 64 (10): 3475-3484. https://doi.org/10.2337/db15-0376
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    Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion
    Shiwani Tiwari, Chris Roel, Rachel Wills, Gabriella Casinelli, Mansoor Tanwir, Karen K. Takane and Nathalie M. Fiaschi-Taesch
    Diabetes 2015 Oct; 64 (10): 3485-3498. https://doi.org/10.2337/db14-1885
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    Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration
    Fabien Delaspre, Rebecca L. Beer, Meritxell Rovira, Wei Huang, Guangliang Wang, Stephen Gee, Maria del Carmen Vitery, Sarah J. Wheelan and Michael J. Parsons
    Diabetes 2015 Oct; 64 (10): 3499-3509. https://doi.org/10.2337/db15-0153
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Immunology and Transplantation

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    Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes
    Aimon K. Alkanani, Naoko Hara, Peter A. Gottlieb, Diana Ir, Charles E. Robertson, Brandie D. Wagner, Daniel N. Frank and Danny Zipris
    Diabetes 2015 Oct; 64 (10): 3510-3520. https://doi.org/10.2337/db14-1847
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    DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes
    Jeffrey D. Price, Chie Hotta-Iwamura, Yongge Zhao, Nicole M. Beauchamp and Kristin V. Tarbell
    Diabetes 2015 Oct; 64 (10): 3521-3531. https://doi.org/10.2337/db14-1880
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    Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes
    Slobodan Culina, Nimesh Gupta, Raphael Boisgard, Georgia Afonso, Marie-Claude Gagnerault, Jordan Dimitrov, Thomas Østerbye, Sune Justesen, Sandrine Luce, Mikhaël Attias, Bruno Kyewski, Søren Buus, F. Susan Wong, Sebastien Lacroix-Desmazes and Roberto Mallone
    Diabetes 2015 Oct; 64 (10): 3532-3542. https://doi.org/10.2337/db15-0024
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Pathophysiology

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    Human Insulinomas Show Distinct Patterns of Insulin Secretion In Vitro
    Jean-Claude Henquin, Myriam Nenquin, Yves Guiot, Jacques Rahier and Christine Sempoux
    Diabetes 2015 Oct; 64 (10): 3543-3553. https://doi.org/10.2337/db15-0527
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Complications

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    Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes
    Shuhua Fu, Shuqian Dong, Meili Zhu, David M. Sherry, Changyun Wang, Zhipeng You, Jody J. Haigh and Yun-Zheng Le
    Diabetes 2015 Oct; 64 (10): 3554-3563. https://doi.org/10.2337/db15-0180
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    Reduction in SGLT1 mRNA Expression in the Ventromedial Hypothalamus Improves the Counterregulatory Responses to Hypoglycemia in Recurrently Hypoglycemic and Diabetic Rats
    Xiaoning Fan, Owen Chan, Yuyan Ding, Wanling Zhu, Jason Mastaitis and Robert Sherwin
    Diabetes 2015 Oct; 64 (10): 3564-3572. https://doi.org/10.2337/db15-0022
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    Removal of Abnormal Myofilament O-GlcNAcylation Restores Ca2+ Sensitivity in Diabetic Cardiac Muscle
    Genaro A. Ramirez-Correa, Junfeng Ma, Chad Slawson, Quira Zeidan, Nahyr S. Lugo-Fagundo, Mingguo Xu, Xiaoxu Shen, Wei Dong Gao, Viviane Caceres, Khalid Chakir, Lauren DeVine, Robert N. Cole, Luigi Marchionni, Nazareno Paolocci, Gerald W. Hart and Anne M. Murphy
    Diabetes 2015 Oct; 64 (10): 3573-3587. https://doi.org/10.2337/db14-1107
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    Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema
    Takeshi Kita, Allen C. Clermont, Nivetha Murugesan, Qunfang Zhou, Kimihiko Fujisawa, Tatsuro Ishibashi, Lloyd Paul Aiello and Edward P. Feener
    Diabetes 2015 Oct; 64 (10): 3588-3599. https://doi.org/10.2337/db15-0317
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Pharmacology and Therapeutics

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    Targeting HSP90 Ameliorates Nephropathy and Atherosclerosis Through Suppression of NF-κB and STAT Signaling Pathways in Diabetic Mice
    Iolanda Lazaro, Ainhoa Oguiza, Carlota Recio, Beñat Mallavia, Julio Madrigal-Matute, Julia Blanco, Jesus Egido, Jose-Luis Martin-Ventura and Carmen Gomez-Guerrero
    Diabetes 2015 Oct; 64 (10): 3600-3613. https://doi.org/10.2337/db14-1926
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    Reversal of New-Onset Type 1 Diabetes With an Agonistic TLR4/MD-2 Monoclonal Antibody
    Kyle J. Bednar, Hiroki Tsukamoto, Kritika Kachapati, Shoichiro Ohta, Yuehong Wu, Jonathan D. Katz, Dana P. Ascherman and William M. Ridgway
    Diabetes 2015 Oct; 64 (10): 3614-3626. https://doi.org/10.2337/db14-1868
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Issues and Events

  • Open Access
    Issues and Events
    Diabetes 2015 Oct; 64 (10): 3627. https://doi.org/10.2337/db15-ie10
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e-Letters: Comments and Responses

  • Open Access
    Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
    Francesco Zaccardi, David R. Webb, Kamlesh Khunti and Melanie J. Davies
    Diabetes 2015 Oct; 64 (10): e35-e36. https://doi.org/10.2337/db15-0649
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  • Open Access
    Comment on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
    Heinrich Taegtmeyer, Christophe Beauloye, Romain Harmancey and Louis Hue
    Diabetes 2015 Oct; 64 (10): e37. https://doi.org/10.2337/db15-0655
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  • Open Access
    Response to Comments on Nolan et al. Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes. Diabetes 2015;64:673–686
    Christopher J. Nolan, Neil B. Ruderman, Steven E. Kahn, Oluf Pedersen and Marc Prentki
    Diabetes 2015 Oct; 64 (10): e38-e39. https://doi.org/10.2337/dbi15-0002
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  • Open Access
    Comment on Alkanani et al. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes 2015;64:3510–3520
    María Esther Mejía-León and Ana María Calderón de la Barca
    Diabetes 2015 Oct; 64 (10): e40. https://doi.org/10.2337/db15-0848
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  • Open Access
    Response to Comment on Alkanani et al. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes 2015;64:3510–3520
    Brandie D. Wagner, Daniel N. Frank and Danny Zipris
    Diabetes 2015 Oct; 64 (10): e41. https://doi.org/10.2337/dbi15-0009
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Diabetes: 64 (10)

In this Issue

October 2015, 64(10)
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