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Islet Studies

Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion

  1. Shinji Hashimoto1,
  2. Naoto Kubota1,2,3,4,
  3. Hiroyuki Sato1,
  4. Motohiro Sasaki1,
  5. Iseki Takamoto1,2,
  6. Tetsuya Kubota1,3,4,5,
  7. Keizo Nakaya1,
  8. Mitsuhiko Noda6,
  9. Kohjiro Ueki1,2 and
  10. Takashi Kadowaki1,2,3⇑
  1. 1Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  2. 2Translational Systems Biology and Medicine Initiative (TSBMI), The University of Tokyo, Tokyo, Japan
  3. 3Clinical Nutrition Program, National Institute of Health and Nutrition, Tokyo, Japan
  4. 4Laboratory for Metabolic Homeostasis, Rikagaku Kenkyusho (RIKEN) Center for Integrative Medical Sciences, Kanagawa, Japan
  5. 5Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
  6. 6Department of Diabetes Research, National Center for Global Health and Medicine, Tokyo, Japan
  1. Corresponding authors: Takashi Kadowaki, kadowaki-3im{at}h.u-tokyo.ac.jp, and Naoto Kubota, nkubota-tky{at}umin.ac.jp.
  1. S.H. and N.K. contributed equally to this work.

Diabetes 2015 Mar; 64(3): 876-886. https://doi.org/10.2337/db14-0432
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Article Information

vol. 64 no. 3 876-886
DOI 
https://doi.org/10.2337/db14-0432
PubMed 
25277391

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received March 16, 2014
  • Accepted September 11, 2014
  • Published in print February 24, 2015.
  • Published online ahead of print October 2, 2014.

Article Versions

  • Previous version (October 2, 2014 - 06:14).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.

Author Information

  1. Shinji Hashimoto1,
  2. Naoto Kubota1,2,3,4,
  3. Hiroyuki Sato1,
  4. Motohiro Sasaki1,
  5. Iseki Takamoto1,2,
  6. Tetsuya Kubota1,3,4,5,
  7. Keizo Nakaya1,
  8. Mitsuhiko Noda6,
  9. Kohjiro Ueki1,2 and
  10. Takashi Kadowaki1,2,3⇑
  1. 1Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
  2. 2Translational Systems Biology and Medicine Initiative (TSBMI), The University of Tokyo, Tokyo, Japan
  3. 3Clinical Nutrition Program, National Institute of Health and Nutrition, Tokyo, Japan
  4. 4Laboratory for Metabolic Homeostasis, Rikagaku Kenkyusho (RIKEN) Center for Integrative Medical Sciences, Kanagawa, Japan
  5. 5Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan
  6. 6Department of Diabetes Research, National Center for Global Health and Medicine, Tokyo, Japan
  1. Corresponding authors: Takashi Kadowaki, kadowaki-3im{at}h.u-tokyo.ac.jp, and Naoto Kubota, nkubota-tky{at}umin.ac.jp.
  1. S.H. and N.K. contributed equally to this work.

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Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion
Shinji Hashimoto, Naoto Kubota, Hiroyuki Sato, Motohiro Sasaki, Iseki Takamoto, Tetsuya Kubota, Keizo Nakaya, Mitsuhiko Noda, Kohjiro Ueki, Takashi Kadowaki
Diabetes Mar 2015, 64 (3) 876-886; DOI: 10.2337/db14-0432

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Insulin Receptor Substrate-2 (Irs2) in Endothelial Cells Plays a Crucial Role in Insulin Secretion
Shinji Hashimoto, Naoto Kubota, Hiroyuki Sato, Motohiro Sasaki, Iseki Takamoto, Tetsuya Kubota, Keizo Nakaya, Mitsuhiko Noda, Kohjiro Ueki, Takashi Kadowaki
Diabetes Mar 2015, 64 (3) 876-886; DOI: 10.2337/db14-0432
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