Diabetes: 66 (10)

October 01 2017; volume 66 issue 10

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In This Issue of Diabetes
Diabetes 2017 Oct; 66 (10): 2533-2534. https://doi.org/10.2337/db17-ti10

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Commentaries

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Sirtuin 6 Builds a Wall Against Inflammation, Trumping Diabetes
William Giblin and David B. Lombard

Diabetes 2017 Oct; 66 (10): 2535-2537. https://doi.org/10.2337/dbi17-0025

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New Tricks for Nrf2: Therapeutic Targeting to Restore BK-β1 Expression?
Sarah J. Chapple and Giovanni E. Mann

Diabetes 2017 Oct; 66 (10): 2538-2540. https://doi.org/10.2337/dbi17-0024

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Metabolism

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Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression
Julia Brun, Flavien Berthou, Mirko Trajkovski, Pierre Maechler, Michanlegelo Foti and Nicolas Bonnet

Diabetes 2017 Oct; 66 (10): 2541-2554. https://doi.org/10.2337/db17-0116

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Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity
Yuanqing Gao, Clarita Layritz, Beata Legutko, Thomas O. Eichmann, Elise Laperrousaz, Valentine S. Moullé, Celine Cruciani-Guglielmacci, Christophe Magnan, Serge Luquet, Stephen C. Woods, Robert H. Eckel, Chun-Xia Yi, Cristina Garcia-Caceres and Matthias H. Tschöp

Diabetes 2017 Oct; 66 (10): 2555-2563. https://doi.org/10.2337/db16-1278

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Hepatic but Not Extrahepatic Insulin Clearance Is Lower in African American Than in European American Women
Francesca Piccinini, David C. Polidori, Barbara A. Gower and Richard N. Bergman

Diabetes 2017 Oct; 66 (10): 2564-2570. https://doi.org/10.2337/db17-0413

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DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver
Xin Tong, Deqiang Zhang, Nicholas Charney, Ethan Jin, Kyle VanDommelen, Kenneth Stamper, Neil Gupta, Johnny Saldate and Lei Yin

Diabetes 2017 Oct; 66 (10): 2571-2582. https://doi.org/10.2337/db16-1600

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Opposite Regulation of Insulin Sensitivity by Dietary Lipid Versus Carbohydrate Excess
Anne-Marie Lundsgaard, Kim A. Sjøberg, Louise D. Høeg, Jacob Jeppesen, Andreas B. Jordy, Annette K. Serup, Andreas M. Fritzen, Henriette Pilegaard, Lene S. Myrmel, Lise Madsen, Jørgen F.P. Wojtaszewski, Erik A. Richter and Bente Kiens

Diabetes 2017 Oct; 66 (10): 2583-2595. https://doi.org/10.2337/db17-0046

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Obesity Studies

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Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance
Su-Yeon Lee, Hui-Young Lee, Jae-Hwi Song, Goon-Tae Kim, Suwon Jeon, Yoo-Jeong Song, Jae Sung Lee, Jang-Ho Hur, Hyun Hee Oh, Shi-Young Park, Soon-Mi Shim, Hyun Joo Yoo, Byung Cheon Lee, Xian-Cheng Jiang, Cheol Soo Choi and Tae-Sik Park

Diabetes 2017 Oct; 66 (10): 2596-2609. https://doi.org/10.2337/db16-1232

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Islet Studies

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Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis
Ida Alenkvist, Nikhil R. Gandasi, Sebastian Barg and Anders Tengholm

Diabetes 2017 Oct; 66 (10): 2610-2622. https://doi.org/10.2337/db17-0050

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Thyroid Hormone Coordinates Pancreatic Islet Maturation During the Zebrafish Larval-to-Juvenile Transition to Maintain Glucose Homeostasis
Hiroki Matsuda, Sri Teja Mullapudi, Yuxi Zhang, Daniel Hesselson and Didier Y.R. Stainier

Diabetes 2017 Oct; 66 (10): 2623-2635. https://doi.org/10.2337/db16-1476

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Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation
Andrew T. Templin, Tanya Samarasekera, Daniel T. Meier, Meghan F. Hogan, Mahnaz Mellati, Michael T. Crow, Richard N. Kitsis, Sakeneh Zraika, Rebecca L. Hull and Steven E. Kahn

Diabetes 2017 Oct; 66 (10): 2636-2645. https://doi.org/10.2337/db16-1352

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SMAD3/Stat3 Signaling Mediates β-Cell Epithelial-Mesenchymal Transition in Chronic Pancreatitis–Related Diabetes
Xiangwei Xiao, Shane Fischbach, Tina Zhang, Congde Chen, Qingfeng Sheng, Ray Zimmerman, Sneha Patnaik, Joseph Fusco, Yungching Ming, Ping Guo, Chiyo Shiota, Krishna Prasadan, Nupur Gangopadhyay, Sohail Z. Husain, Henry Dong and George K. Gittes

Diabetes 2017 Oct; 66 (10): 2646-2658. https://doi.org/10.2337/db17-0537

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Pathophysiology

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Myeloid Sirtuin 6 Deficiency Causes Insulin Resistance in High-Fat Diet–Fed Mice by Eliciting Macrophage Polarization Toward an M1 Phenotype
Youngyi Lee, Sun-O Ka, Hye-Na Cha, Yu-Na Chae, Mi-Kyung Kim, So-Young Park, Eun Ju Bae and Byung-Hyun Park

Diabetes 2017 Oct; 66 (10): 2659-2668. https://doi.org/10.2337/db16-1446

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Low-Dose Persistent Organic Pollutants Impair Insulin Secretory Function of Pancreatic β-Cells: Human and In Vitro Evidence
Yu-Mi Lee, Chae-Myeong Ha, Se-A Kim, Themis Thoudam, Young-Ran Yoon, Dae-Jung Kim, Hyeon-Chang Kim, Hyo-Bang Moon, Sungmi Park, In-Kyu Lee and Duk-Hee Lee

Diabetes 2017 Oct; 66 (10): 2669-2680. https://doi.org/10.2337/db17-0188

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Complications

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Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet–Induced Diabetic Mice
Tong Lu, Xiaojing Sun, Yong Li, Qiang Chai, Xiao-Li Wang and Hon-Chi Lee

Diabetes 2017 Oct; 66 (10): 2681-2690. https://doi.org/10.2337/db17-0181

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NADPH Oxidase Nox5 Accelerates Renal Injury in Diabetic Nephropathy
Jay C. Jha, Claudine Banal, Jun Okabe, Stephen P. Gray, Thushan Hettige, Bryna S.M. Chow, Vicki Thallas-Bonke, Lisanne De Vos, Chet E. Holterman, Melinda T. Coughlan, David A. Power, Alison Skene, Elif I. Ekinci, Mark E. Cooper, Rhian M. Touyz, Chris R. Kennedy and Karin Jandeleit-Dahm

Diabetes 2017 Oct; 66 (10): 2691-2703. https://doi.org/10.2337/db16-1585

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Genetics/Genomes/Proteomics/Metabolomics

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Genetic Susceptibility, Change in Physical Activity, and Long-term Weight Gain
Tiange Wang, Tao Huang, Yoriko Heianza, Dianjianyi Sun, Yan Zheng, Wenjie Ma, Majken K. Jensen, Jae H. Kang, Janey L. Wiggs, Louis R. Pasquale, Eric B. Rimm, JoAnn E. Manson, Frank B. Hu, Walter C. Willett and Lu Qi

Diabetes 2017 Oct; 66 (10): 2704-2712. https://doi.org/10.2337/db17-0071

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Structural Basis and Genotype–Phenotype Correlations of INSR Mutations Causing Severe Insulin Resistance
Jun Hosoe, Hiroko Kadowaki, Fuyuki Miya, Katsuya Aizu, Tomoyuki Kawamura, Ichiro Miyata, Kenichi Satomura, Takeru Ito, Kazuo Hara, Masaki Tanaka, Hiroyuki Ishiura, Shoji Tsuji, Ken Suzuki, Minaka Takakura, Keith A. Boroevich, Tatsuhiko Tsunoda, Toshimasa Yamauchi, Nobuhiro Shojima and Takashi Kadowaki

Diabetes 2017 Oct; 66 (10): 2713-2723. https://doi.org/10.2337/db17-0301

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Errata

Open Access
Erratum. Weight Loss After Bariatric Surgery Reverses Insulin-Induced Increases in Brain Glucose Metabolism of the Morbidly Obese. Diabetes 2013;62:2747–2751
Jetro J. Tuulari, Henry K. Karlsson, Jussi Hirvonen, Jarna C. Hannukainen, Marco Bucci, Mika Helmiö, Jari Ovaska, Minna Soinio, Paulina Salminen, Nina Savisto, Lauri Nummenmaa and Pirjo Nuutila

Diabetes 2017 Oct; 66 (10): 2724. https://doi.org/10.2337/db17-er10a

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Open Access
Erratum. Association Between Long-term Exposure to Air Pollution and Biomarkers Related to Insulin Resistance, Subclinical Inflammation, and Adipokines. Diabetes 2016;65:3314–3326
Kathrin Wolf, Anita Popp, Alexandra Schneider, Susanne Breitner, Regina Hampel, Wolfgang Rathmann, Christian Herder, Michael Roden, Wolfgang Koenig, Christa Meisinger and Annette Peters, for the KORA-Study Group

Diabetes 2017 Oct; 66 (10): 2725. https://doi.org/10.2337/db17-er10b

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Issues and Events

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Issues and Events
Diabetes 2017 Oct; 66 (10): 2726. https://doi.org/10.2337/db17-ie10

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In This Issue

Commentaries

Metabolism

Obesity Studies

Islet Studies

Pathophysiology

Complications

Genetics/Genomes/Proteomics/Metabolomics

Errata

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