Diabetes: 66 (4)

April 01 2017; volume 66 issue 4

In This Issue

Open Access
In This Issue of Diabetes
Diabetes 2017 Apr; 66 (4): 789-790. https://doi.org/10.2337/db17-ti04

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Perspectives in Diabetes

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Proximal Tubulopathy: Prime Mover and Key Therapeutic Target in Diabetic Kidney Disease
Richard E. Gilbert

Diabetes 2017 Apr; 66 (4): 791-800. https://doi.org/10.2337/db16-0796

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Commentaries

Open Access
Stratifying Diabetes: Desperately Seeking Specificity
Richard David Leslie and Samuel Thomas Jerram

Diabetes 2017 Apr; 66 (4): 801-803. https://doi.org/10.2337/dbi16-0074

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Open Access
Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?
Julie A. Chowen, Tamas L. Horvath and Jesús Argente

Diabetes 2017 Apr; 66 (4): 804-805. https://doi.org/10.2337/dbi16-0073

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Metabolism

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Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype
Mahmoud Al-Majdoub, Arslan Ali, Petter Storm, Anders H. Rosengren, Leif Groop and Peter Spégel

Diabetes 2017 Apr; 66 (4): 806-814. https://doi.org/10.2337/db16-0779

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Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study
Amalia Gastaldelli, Melania Gaggini and Ralph A. DeFronzo

Diabetes 2017 Apr; 66 (4): 815-822. https://doi.org/10.2337/db16-1167

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Evidence That the Sympathetic Nervous System Elicits Rapid, Coordinated, and Reciprocal Adjustments of Insulin Secretion and Insulin Sensitivity During Cold Exposure
Gregory J. Morton, Kenjiro Muta, Karl J. Kaiyala, Jennifer M. Rojas, Jarrad M. Scarlett, Miles E. Matsen, Jarrell T. Nelson, Nikhil K. Acharya, Francesca Piccinini, Darko Stefanovski, Richard N. Bergman, Gerald J. Taborsky, Steven E. Kahn and Michael W. Schwartz

Diabetes 2017 Apr; 66 (4): 823-834. https://doi.org/10.2337/db16-1351

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Deletion of CD1d in Adipocytes Aggravates Adipose Tissue Inflammation and Insulin Resistance in Obesity
Jin Young Huh, Jeu Park, Jong In Kim, Yoon Jeong Park, Yun Kyung Lee and Jae Bum Kim

Diabetes 2017 Apr; 66 (4): 835-847. https://doi.org/10.2337/db16-1122

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Obesity-Associated Alterations in Glucose Metabolism Are Reversed by Chronic Bilateral Stimulation of the Abdominal Vagus Nerve
Charles-Henri Malbert, Chloé Picq, Jean-Louis Divoux, Christine Henry and Michael Horowitz

Diabetes 2017 Apr; 66 (4): 848-857. https://doi.org/10.2337/db16-0847

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FGF21 Mediates the Thermogenic and Insulin-Sensitizing Effects of Dietary Methionine Restriction but Not Its Effects on Hepatic Lipid Metabolism
Desiree Wanders, Laura A. Forney, Kirsten P. Stone, David H. Burk, Alicia Pierse and Thomas W. Gettys

Diabetes 2017 Apr; 66 (4): 858-867. https://doi.org/10.2337/db16-1212

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Inhibition of Gastric Inhibitory Polypeptide Receptor Signaling in Adipose Tissue Reduces Insulin Resistance and Hepatic Steatosis in High-Fat Diet–Fed Mice
Erina Joo, Norio Harada, Shunsuke Yamane, Toru Fukushima, Daisuke Taura, Kanako Iwasaki, Akiko Sankoda, Kimitaka Shibue, Takanari Harada, Kazuyo Suzuki, Akihiro Hamasaki and Nobuya Inagaki

Diabetes 2017 Apr; 66 (4): 868-879. https://doi.org/10.2337/db16-0758

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Bariatric Surgery Enhances Splanchnic Vascular Responses in Patients With Type 2 Diabetes
Henri Honka, Jukka Koffert, Saila Kauhanen, Jarmo Teuho, Saija Hurme, Andrea Mari, Andreas Lindqvist, Nils Wierup, Leif Groop and Pirjo Nuutila

Diabetes 2017 Apr; 66 (4): 880-885. https://doi.org/10.2337/db16-0762

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Signal Transduction

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Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor
Siegfried Ussar, Max-Felix Haering, Shiho Fujisaka, Dominik Lutter, Kevin Y. Lee, Ning Li, Georg K. Gerber, Lynn Bry and C. Ronald Kahn

Diabetes 2017 Apr; 66 (4): 886-896. https://doi.org/10.2337/db15-1349

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Loss of α₂δ-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes
Vincenzo Mastrolia, Sylvia M. Flucher, Gerald J. Obermair, Mathias Drach, Helene Hofer, Erik Renström, Arnold Schwartz, Jörg Striessnig, Bernhard E. Flucher and Petronel Tuluc

Diabetes 2017 Apr; 66 (4): 897-907. https://doi.org/10.2337/db16-0336

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Obesity Studies

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Inhibiting Microglia Expansion Prevents Diet-Induced Hypothalamic and Peripheral Inflammation
Caroline André, Omar Guzman-Quevedo, Charlotte Rey, Julie Rémus-Borel, Samantha Clark, Ashley Castellanos-Jankiewicz, Elodie Ladeveze, Thierry Leste-Lasserre, Agnes Nadjar, Djoher Nora Abrous, Sophie Laye and Daniela Cota

Diabetes 2017 Apr; 66 (4): 908-919. https://doi.org/10.2337/db16-0586

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Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity
Mauricio D. Dorfman, Jordan E. Krull, Jarrad M. Scarlett, Stephan J. Guyenet, Mini P. Sajan, Vincent Damian, Hong T. Nguyen, Michael Leitges, Gregory J. Morton, Robert V. Farese, Michael W. Schwartz and Joshua P. Thaler

Diabetes 2017 Apr; 66 (4): 920-934. https://doi.org/10.2337/db16-0482

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Rare Loss-of-Function Variants in NPC1 Predispose to Human Obesity
Ruixin Liu, Yaoyu Zou, Jie Hong, Min Cao, Bin Cui, Huiwen Zhang, Maopei Chen, Juan Shi, Tinglu Ning, Shaoqian Zhao, Wen Liu, Hui Xiong, Cuijie Wei, Zhengqing Qiu, Weiqiong Gu, Yifei Zhang, Wanyu Li, Lin Miao, Yingkai Sun, Minglan Yang, Rui Wang, Qinyun Ma, Min Xu, Yu Xu, Tiange Wang, Kei-hang Katie Chan, Xianbo Zuo, Haoyan Chen, Lu Qi, Shenghan Lai, Shumin Duan, Baoliang Song, Yufang Bi, Simin Liu, Weiqing Wang, Guang Ning and Jiqiu Wang

Diabetes 2017 Apr; 66 (4): 935-947. https://doi.org/10.2337/db16-0877

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Islet Studies

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Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis
Dan Zhu, Li Xie, Youhou Kang, Subhankar Dolai, Jakob Bondo Hansen, Tairan Qin, Huanli Xie, Tao Liang, Deborah C. Rubin, Lucy Osborne and Herbert Y. Gaisano

Diabetes 2017 Apr; 66 (4): 948-959. https://doi.org/10.2337/db16-0636

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Reestablishment of Glucose Inhibition of Glucagon Secretion in Small Pseudoislets
Christopher A. Reissaus and David W. Piston

Diabetes 2017 Apr; 66 (4): 960-969. https://doi.org/10.2337/db16-1291

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Immunology and Transplantation

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α-1 Antitrypsin Enhances Islet Engraftment by Suppression of Instant Blood-Mediated Inflammatory Reaction
Jingjing Wang, Zhen Sun, Wenyu Gou, David B. Adams, Wanxing Cui, Katherine A. Morgan, Charlie Strange and Hongjun Wang

Diabetes 2017 Apr; 66 (4): 970-980. https://doi.org/10.2337/db16-1036

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Differential Impact of Chronic Hyperglycemia on Humoral Versus Cellular Primary Alloimmunity
Nicholas H. Bishop, Michelle K. Nelsen, K. Scott Beard, Marilyne Coulombe and Ronald G. Gill

Diabetes 2017 Apr; 66 (4): 981-986. https://doi.org/10.2337/db16-0218

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Neu5Gc and α1-3 GAL Xenoantigen Knockout Does Not Affect Glycemia Homeostasis and Insulin Secretion in Pigs
Apolline Salama, Mathilde Mosser, Xavier Lévêque, Andrea Perota, Jean-Paul Judor, Corentin Danna, Sylvie Pogu, Anne Mouré, Dominique Jégou, Nicolas Gaide, Jérôme Abadie, Olivier Gauthier, Jean-Paul Concordet, Stéphanie Le Bas-Bernardet, David Riochet, Ludmilla Le Berre, Jérémy Hervouet, David Minault, Pierre Weiss, Jérôme Guicheux, Sophie Brouard, Steffi Bosch, Irina Lagutina, Roberto Duchi, Giovanna Lazzari, Emanuele Cozzi, Gilles Blancho, Sophie Conchon, Cesare Galli, Jean-Paul Soulillou and Jean-Marie Bach

Diabetes 2017 Apr; 66 (4): 987-993. https://doi.org/10.2337/db16-1060

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Pathophysiology

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Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes
Tony Jourdan, Gergő Szanda, Resat Cinar, Grzegorz Godlewski, David J. Holovac, Joshua K. Park, Sarah Nicoloro, Yuefei Shen, Jie Liu, Avi Z. Rosenberg, Ziyi Liu, Michael P. Czech and George Kunos

Diabetes 2017 Apr; 66 (4): 994-1007. https://doi.org/10.2337/db16-1199

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PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity
Yasuhiro Onogi, Tsutomu Wada, Chie Kamiya, Kento Inata, Takatoshi Matsuzawa, Yuka Inaba, Kumi Kimura, Hiroshi Inoue, Seiji Yamamoto, Yoko Ishii, Daisuke Koya, Hiroshi Tsuneki, Masakiyo Sasahara and Toshiyasu Sasaoka

Diabetes 2017 Apr; 66 (4): 1008-1021. https://doi.org/10.2337/db16-0881

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An Activating Mutation in STAT3 Results in Neonatal Diabetes Through Reduced Insulin Synthesis
Teresa Velayos, Rosa Martínez, Milagros Alonso, Koldo Garcia-Etxebarria, Anibal Aguayo, Cristina Camarero, Inés Urrutia, Idoia Martínez de LaPiscina, Raquel Barrio, Izortze Santin and Luis Castaño

Diabetes 2017 Apr; 66 (4): 1022-1029. https://doi.org/10.2337/db16-0867

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Complications

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The Sodium–Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model
Michael Joubert, Benoît Jagu, David Montaigne, Xavier Marechal, Angela Tesse, Audrey Ayer, Lucile Dollet, Cédric Le May, Gilles Toumaniantz, Alain Manrique, Flavien Charpentier, Bart Staels, Jocelyne Magré, Bertrand Cariou and Xavier Prieur

Diabetes 2017 Apr; 66 (4): 1030-1040. https://doi.org/10.2337/db16-0733

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Perturbation of Retinoid Homeostasis Increases Malformation Risk in Embryos Exposed to Pregestational Diabetes
Leo M.Y. Lee, Maran B.W. Leung, Rachel C.Y. Kwok, Yun Chung Leung, Chi Chiu Wang, Peter J. McCaffery, Andrew J. Copp and Alisa S.W. Shum

Diabetes 2017 Apr; 66 (4): 1041-1051. https://doi.org/10.2337/db15-1570

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Proinflammatory Effects of Hypoglycemia in Humans With or Without Diabetes
Jacqueline M. Ratter, Hanne M.M. Rooijackers, Cees J. Tack, Anneke G.M. Hijmans, Mihai G. Netea, Bastiaan E. de Galan and Rinke Stienstra

Diabetes 2017 Apr; 66 (4): 1052-1061. https://doi.org/10.2337/db16-1091

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Pharmacology and Therapeutics

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Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight
Rozita H. Anderberg, Jennifer E. Richard, Kim Eerola, Lorena López-Ferreras, Elin Banke, Caroline Hansson, Hans Nissbrandt, Filip Berqquist, Fiona M. Gribble, Frank Reimann, Ingrid Wernstedt Asterholm, Christophe M. Lamy and Karolina P. Skibicka

Diabetes 2017 Apr; 66 (4): 1062-1073. https://doi.org/10.2337/db16-0755

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Genetics/Genomes/Proteomics/Metabolomics

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Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis
Petr Volkov, Karl Bacos, Jones K. Ofori, Jonathan Lou S. Esguerra, Lena Eliasson, Tina Rönn and Charlotte Ling

Diabetes 2017 Apr; 66 (4): 1074-1085. https://doi.org/10.2337/db16-0996

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dUTPase (DUT) Is Mutated in a Novel Monogenic Syndrome With Diabetes and Bone Marrow Failure
Reinaldo Sousa Dos Santos, Mathilde Daures, Anne Philippi, Sophie Romero, Lorella Marselli, Piero Marchetti, Valérie Senée, Delphine Bacq, Céline Besse, Baz Baz, Laura Marroquí, Sarah Ivanoff, Julien Masliah-Planchon, Marc Nicolino, Jean Soulier, Gérard Socié, Decio L. Eizirik, Jean-François Gautier and Cécile Julier

Diabetes 2017 Apr; 66 (4): 1086-1096. https://doi.org/10.2337/db16-0839

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Errata

Open Access
Erratum. Metabolomic Profile of Low–Copy Number Carriers at the Salivary α-Amylase Gene Suggests a Metabolic Shift Toward Lipid-Based Energy Production. Diabetes 2016;65:3362–3368
Abdelilah Arredouani, Matteo Stocchero, Nicola Culeddu, Julia El-Sayed Moustafa, D.E.S.I.R. Study Group, Jean Tichet, Beverley Balkau, Thierry Brousseau, Marco Manca and Mario Falchi

Diabetes 2017 Apr; 66 (4): 1097. https://doi.org/10.2337/db17-er04a

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Open Access
Erratum. High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes 2016;65:3091–3103
Joanne T.M. Tan, Hamish C.G. Prosser, Louise L. Dunn, Laura Z. Vanags, Anisyah Ridiandries, Tania Tsatralis, Laura Leece, Zoë E. Clayton, Sui Ching G. Yuen, Stacy Robertson, Yuen Ting Lam, David S. Celermajer, Martin K.C. Ng and Christina A. Bursill

Diabetes 2017 Apr; 66 (4): 1097. https://doi.org/10.2337/db17-er04b

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Expression of Concern

Open Access
Expression of Concern. EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice. Diabetes 2009;58:2910–2919. DOI: 10.2337/db08-0506. PMID: 19696185
Patricia O. Prada, Eduardo R. Ropelle, Rosa H. Mourão, Claudio T. de Souza, Jose R. Pauli, Dennys E. Cintra, André Schenka, Silvana A. Rocco, Roberto Rittner, Kleber G. Franchini, José Vassallo, Lício A. Velloso, José B. Carvalheira and Mario J.A. Saad

Diabetes 2017 Apr; 66 (4): 1098. https://doi.org/10.2337/db17-ec04a

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Issues and Events

Open Access
Issues and Events
Diabetes 2017 Apr; 66 (4): 1099. https://doi.org/10.2337/db17-ie04

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Table of Contents

In This Issue

Perspectives in Diabetes

Commentaries

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics/Genomes/Proteomics/Metabolomics

Errata

Expression of Concern

Issues and Events

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