Skip to main content
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • My Cart
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in
  • My Cart

Search

  • Advanced search
Diabetes
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Statement of Retraction

Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014:63:3974. DOI: 10.2337/db14-er11

  1. Luan Shu,
  2. Nadine S. Sauter,
  3. Fabienne T. Schulthess,
  4. Aleksey V. Matveyenko,
  5. José Oberholzer and
  6. Kathrin Maedler
Diabetes 2017 Jun; 66(6): 1729-1730. https://doi.org/10.2337/db17-rt06a
PreviousNext
  • Article
  • Info & Metrics
  • PDF
Loading

The above-cited article has been retracted by the American Diabetes Association (ADA), the publisher of Diabetes. This article was previously the subject of an expression of concern in the August 2016 issue of the journal (1). As noted in the expression of concern, the ADA asked the corresponding author’s institution, the University of Bremen, to review the following issues with the article:

  • In the erratum for Fig. 5D (2), the “cleaved Caspase 3” panel (lanes 7 and 8 in the original blots and lanes 4 & 5 in the corrected version) closely resembles the “cleaved Casp3” panel in Fig. 3D in the original version of the article (3).

  • Likewise, in the original article (3), Fig. 5D (lanes 4 and 5) resembles the “cleaved Casp3” panel in Fig. 3D.

  • In the erratum (2), the “cleaved Caspase 3” panel, lanes 1 and 2, closely resembles a horizontal mirror image of Fig. 2F, TCF7L2 panel, lanes 3 and 4, from a 2009 article by the same author group in Human Molecular Genetics (4). In addition, lanes 4 and 5 of the corrected Fig. 5D in the erratum closely resemble a horizontal mirror image of Fig. 2F, TCF7L2 panel, lanes 1 and 2, of the Human Molecular Genetics article.

The issues described in the August 2016 expression of concern were reviewed by an investigative commission appointed by the University of Bremen. The lead and corresponding authors contacted the ADA in November 2016 to provide a summary of the university’s investigation. According to the authors, the university committee independently reviewed all of the material associated with the study, including the original raw data and supporting data from replica experiments. The committee determined that Fig. 5D in the Diabetes article is correct and that “misrepresentation” occurred in the original Fig. 2F of the Human Molecular Genetics article. A corrigendum to replace Fig. 2F in the Human Molecular Genetics article was published in March 2015 (5).

According to the authors, the committee also concluded that duplication occurred between Fig. 3D and Fig. 5D of the Diabetes article (2,3). The committee determined that the “cleaved Casp3” panel in Fig. 3D is “incorrect” and that the “cleaved Caspase 3” panel in Fig. 5D is correct. At the recommendation of the Rector of the University of Bremen, the authors proposed to publish an erratum to correct “the wrongly placed western blot band.” This recommendation is also expressed in the Rector’s statement about the results of the university’s investigation (6), which states that the Rector “obliged Dr. Mädler to communicate the image duplications identified in the investigations to the publishers of the concerned journals and possibly publish Errata in consultation with the co-authors.”

On the basis of its review, however, ADA’s Panel on Ethical Scientific Programs (ESP) has concluded that the multiple confirmed duplications involving this article, one of which was introduced with the publication of the 2014 erratum (2), compromise the overall reliability of the data. Furthermore, the ESP has determined that such concerns regarding the reliability of the data cannot be sufficiently mitigated by publishing another erratum with another image; therefore, the Panel recommends to retract the article, and ADA has accepted this recommendation.

Diabetes is a member journal of the Committee on Publication Ethics (COPE), and ADA’s decision to accept the Panel’s recommendation to retract the article is in agreement with COPE’s guideline that journals should consider retracting an article when there is “clear evidence that the findings are unreliable, either as a result of misconduct (e.g., data fabrication) or honest error (e.g., miscalculation or experimental error)” (7).

  • © 2017 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

References

  1. ↵
    1. Shu L,
    2. Sauter NS,
    3. Schulthess FT,
    4. Matveyenko AV,
    5. Oberholzer J,
    6. Maedler K
    . Expression of concern. Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014;63:3974. DOI: 10.2337/db14-er11. Diabetes 2016;65:2461. https://doi.org/10.2337/db16-ec08
    OpenUrlAbstract/FREE Full Text
  2. ↵
    1. Shu L,
    2. Sauter NS,
    3. Schulthess FT,
    4. Matveyenko AV,
    5. Oberholzer J,
    6. Maedler K
    . Erratum. Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets. Diabetes 2014;63:3974. https://doi.org/10.2337/db14-er11
    OpenUrlFREE Full Text
  3. ↵
    1. Shu L,
    2. Sauter NS,
    3. Schulthess FT,
    4. Matveyenko AV,
    5. Oberholzer J,
    6. Maedler K
    . Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets. Diabetes 2008;57:645–653. https://doi.org/10.2337/db07-0847
    OpenUrlAbstract/FREE Full Text
  4. ↵
    1. Shu L,
    2. Matveyenko AV,
    3. Kerr-Conte J,
    4. Cho J-H,
    5. McIntosh CHS,
    6. Maedler K
    . Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet 2009;18:2388–2399. https://doi.org/10.1093/hmg/ddp178
    OpenUrlAbstract/FREE Full Text
  5. ↵
    1. Shu L,
    2. Matveyenko AV,
    3. Kerr-Conte J,
    4. Cho J-H,
    5. McIntosh CHS,
    6. Maedler K
    . Erratum. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function. Hum Mol Genet 2015;24:3004. https://doi.org/10.1093/hmg/ddv075
    OpenUrlFREE Full Text
  6. ↵
    1. University of Bremen
    . Translation of the Rector’s statement about the results of the investigation of the Committee for the Investigation of Allegations of Scientific Misconduct of the University of Bremen concerning allegations against Dr. Kathrin Mädler [Internet], 2016. Available from http://www.uni-bremen.de/fileadmin/user_upload/single_sites/referate/referat06/OfficialStatement_Rector.pdf. Accessed 13 March 2017
  7. ↵
    1. Committee on Publication Ethics
    . Retraction guidelines [Internet], 2009. Available from http://publicationethics.org/files/retraction%20guidelines_0.pdf. Accessed 13 March 2017
PreviousNext
Back to top
Diabetes: 66 (6)

In this Issue

June 2017, 66(6)
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by Author
  • Masthead (PDF)
Sign up to receive current issue alerts
View Selected Citations (0)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014:63:3974. DOI: 10.2337/db14-er11
(Your Name) has forwarded a page to you from Diabetes
(Your Name) thought you would like to see this page from the Diabetes web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014:63:3974. DOI: 10.2337/db14-er11
Luan Shu, Nadine S. Sauter, Fabienne T. Schulthess, Aleksey V. Matveyenko, José Oberholzer, Kathrin Maedler
Diabetes Jun 2017, 66 (6) 1729-1730; DOI: 10.2337/db17-rt06a

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Statement of Retraction. Transcription Factor 7-Like 2 Regulates β-Cell Survival and Function in Human Pancreatic Islets. Diabetes 2008;57:645–653. DOI: 10.2337/db07-0847; and erratum. Diabetes 2014:63:3974. DOI: 10.2337/db14-er11
Luan Shu, Nadine S. Sauter, Fabienne T. Schulthess, Aleksey V. Matveyenko, José Oberholzer, Kathrin Maedler
Diabetes Jun 2017, 66 (6) 1729-1730; DOI: 10.2337/db17-rt06a
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • References
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Statement of Retraction. Kristina Blaslov, Višjna Kokić Maleš, Slaven Kokić, and Ivan Kruljac. 1909-P: The Platelet-Derived Growth Factor a—An Additional Pathophysiological Factor in Hepatic Steatosis and Fibrosis Development Both in Patients with Hepatitis C and Patients with Prediabetes. Diabetes 2019;68(Suppl. 1). https://doi.org/10.2337/db19-1909-P
  • Statement of Retraction. EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice. Diabetes 2009;58:2910–2919. DOI: 10.2337/db08-0506. PMID: 19696185
Show more Statement of Retraction

Similar Articles

Navigate

  • Current Issue
  • Online Ahead of Print
  • Scientific Sessions Abstracts
  • Collections
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • Advertising
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes Care
  • Clinical Diabetes
  • Diabetes Spectrum
  • Scientific Sessions Abstracts
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org

© 2021 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.