Diabetes: 67 (11)

November 01 2018; volume 67 issue 11

In This Issue

Open Access
In This Issue of Diabetes
Diabetes 2018 Nov; 67 (11): 2127-2128. https://doi.org/10.2337/db18-ti11

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Perspectives in Diabetes

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Hepatic Insulin Clearance in Regulation of Systemic Insulin Concentrations—Role of Carbohydrate and Energy Availability
Kirstine N. Bojsen-Møller, Anne-Marie Lundsgaard, Sten Madsbad, Bente Kiens and Jens Juul Holst

Diabetes 2018 Nov; 67 (11): 2129-2136. https://doi.org/10.2337/db18-0539

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Open Access
Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?
Jacob E. Friedman

Diabetes 2018 Nov; 67 (11): 2137-2151. https://doi.org/10.2337/dbi17-0011

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Commentaries

Open Access
Mitochondrial ADP Sensitivity and Transport: New Insights Into Diet-Induced Mitochondrial Impairments
Corey R. Hart and Ian R. Lanza

Diabetes 2018 Nov; 67 (11): 2152-2153. https://doi.org/10.2337/dbi18-0030

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Open Access
Exosomes or Microvesicles, a Secreted Subcellular Organelle Contributing to Inflammation and Diabetes
Yang D. Dai and Peter Dias

Diabetes 2018 Nov; 67 (11): 2154-2156. https://doi.org/10.2337/dbi18-0021

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Metabolism

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Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents
Teayoun Kim, Cassie L. Holleman, Shelly Nason, Deanna M. Arble, Nickki Ottaway, Joseph Chabenne, Christine Loyd, Jeong-a Kim, Darleen Sandoval, Daniel J. Drucker, Richard DiMarchi, Diego Perez-Tilve and Kirk M. Habegger

Diabetes 2018 Nov; 67 (11): 2157-2166. https://doi.org/10.2337/db18-0068

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Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis
Yuxin Wu, Quan Pan, Hui Yan, Kebin Zhang, Xiaoqin Guo, Zihui Xu, Wanbao Yang, Yajuan Qi, Cathy A. Guo, Caitlyn Hornsby, Lin Zhang, Aimin Zhou, Ling Li, Yunmei Chen, Weiping Zhang, Yuxiang Sun, Hongting Zheng, Fred Wondisford, Ling He and Shaodong Guo

Diabetes 2018 Nov; 67 (11): 2167-2182. https://doi.org/10.2337/db18-0674

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H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK
Tingting Geng, Ya Liu, Yetao Xu, Ying Jiang, Na Zhang, Zhangsheng Wang, Gordon G. Carmichael, Hugh S. Taylor, Da Li and Yingqun Huang

Diabetes 2018 Nov; 67 (11): 2183-2198. https://doi.org/10.2337/db18-0370

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High-Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity
Paula M. Miotto, Paul J. LeBlanc and Graham P. Holloway

Diabetes 2018 Nov; 67 (11): 2199-2205. https://doi.org/10.2337/db18-0417

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Signal Transduction

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Inactivation of p66Shc Decreases Afferent Arteriolar K_ATP Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats
Bradley S. Miller, Shoshana R. Blumenthal, Alexey Shalygin, Kevin D. Wright, Alexander Staruschenko, John D. Imig and Andrey Sorokin

Diabetes 2018 Nov; 67 (11): 2206-2212. https://doi.org/10.2337/db18-0308

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Obesity Studies

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SF1-Specific AMPKα1 Deletion Protects Against Diet-Induced Obesity
Patricia Seoane-Collazo, Juan Roa, Eva Rial-Pensado, Laura Liñares-Pose, Daniel Beiroa, Francisco Ruíz-Pino, Tania López-González, Donald A. Morgan, José Ángel Pardavila, María Jesús Sánchez-Tapia, Noelia Martínez-Sánchez, Cristina Contreras, Miguel Fidalgo, Carlos Diéguez, Roberto Coppari, Kamal Rahmouni, Rubén Nogueiras, Manuel Tena-Sempere and Miguel López

Diabetes 2018 Nov; 67 (11): 2213-2226. https://doi.org/10.2337/db17-1538

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SRY-Box Containing Gene 4 Promotes Liver Steatosis by Upregulation of SREBP-1c
Yang Jiao, Jiejie Zhao, Zhijian Zhang, Min Li, Xi Yu, Yanying Yang, Jie Liu, Shengjie Liao, Duanzhuo Li, Yuxing Wang, Die Zhang, Yulu Chen, Guojun Shi, Bin Liu, Yan Lu and Xiaoying Li

Diabetes 2018 Nov; 67 (11): 2227-2238. https://doi.org/10.2337/db18-0184

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Islet Studies

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Somatostatin Is Only Partly Required for the Glucagonostatic Effect of Glucose but Is Necessary for the Glucagonostatic Effect of K_ATP Channel Blockers
Bao-Khanh Lai, Heeyoung Chae, Ana Gómez-Ruiz, Panpan Cheng, Paola Gallo, Nancy Antoine, Christophe Beauloye, Jean-Christophe Jonas, Victor Seghers, Susumu Seino and Patrick Gilon

Diabetes 2018 Nov; 67 (11): 2239-2253. https://doi.org/10.2337/db17-0880

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Contribution of the Long Noncoding RNA H19 to β-Cell Mass Expansion in Neonatal and Adult Rodents
Clara Sanchez-Parra, Cécile Jacovetti, Olivier Dumortier, Kailun Lee, Marie-Line Peyot, Claudiane Guay, Marc Prentki, D. Ross Laybutt, Emmanuel Van Obberghen and Romano Regazzi

Diabetes 2018 Nov; 67 (11): 2254-2267. https://doi.org/10.2337/db18-0201

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Whole-Organism Chemical Screening Identifies Modulators of Pancreatic β-Cell Function
Hiroki Matsuda, Sri Teja Mullapudi, Yu Hsuan Carol Yang, Hideki Masaki, Daniel Hesselson and Didier Y.R. Stainier

Diabetes 2018 Nov; 67 (11): 2268-2279. https://doi.org/10.2337/db17-1223

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Glucolipotoxicity-Inhibited miR-299-5p Regulates Pancreatic β-Cell Function and Survival
Qiqing Huang, Weiyan You, Yating Li, Yi Sun, Yuncai Zhou, Yan Zhang, Dechen Liu, Shanshan Zhan, Yunxia Zhu and Xiao Han

Diabetes 2018 Nov; 67 (11): 2280-2292. https://doi.org/10.2337/db18-0223

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Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic β-Cell
Tatsuyoshi Kono, Xin Tong, Solaema Taleb, Robert N. Bone, Hitoshi Iida, Chih-Chun Lee, Paul Sohn, Patrick Gilon, Michael W. Roe and Carmella Evans-Molina

Diabetes 2018 Nov; 67 (11): 2293-2304. https://doi.org/10.2337/db17-1351

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β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes
Elad Horwitz, Lars Krogvold, Sophia Zhitomirsky, Avital Swisa, Maya Fischman, Tsuria Lax, Tehila Dahan, Noa Hurvitz, Noa Weinberg-Corem, Agnes Klochendler, Alvin C. Powers, Marcela Brissova, Anne Jörns, Sigurd Lenzen, Benjamin Glaser, Knut Dahl-Jørgensen and Yuval Dor

Diabetes 2018 Nov; 67 (11): 2305-2318. https://doi.org/10.2337/db17-1006

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Immunology and Transplantation

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Extending Remission and Reversing New-Onset Type 1 Diabetes by Targeted Ablation of Autoreactive T Cells
Kaitlin R. Carroll, Eileen E. Elfers, Joseph J. Stevens, Jonathan P. McNally, David A. Hildeman, Michael B. Jordan and Jonathan D. Katz

Diabetes 2018 Nov; 67 (11): 2319-2328. https://doi.org/10.2337/db18-0204

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Reduction in White Blood Cell, Neutrophil, and Red Blood Cell Counts Related to Sex, HLA, and Islet Autoantibodies in Swedish TEDDY Children at Increased Risk for Type 1 Diabetes
Falastin Salami, Hye-Seung Lee, Eva Freyhult, Helena Elding Larsson, Åke Lernmark, Carina Törn and the TEDDY Study Group

Diabetes 2018 Nov; 67 (11): 2329-2336. https://doi.org/10.2337/db18-0355

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Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
Mijke Buitinga, Aïsha Callebaut, Fernanda Marques Câmara Sodré, Inne Crèvecoeur, Gabriele Blahnik-Fagan, Mei-Ling Yang, Marco Bugliani, David Arribas-Layton, Meghan Marré, Dana P. Cook, Etienne Waelkens, Roberto Mallone, Jon D. Piganelli, Piero Marchetti, Mark J. Mamula, Rita Derua, Eddie A. James, Chantal Mathieu and Lut Overbergh

Diabetes 2018 Nov; 67 (11): 2337-2348. https://doi.org/10.2337/db18-0295

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Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice
Christopher S. Wilson, Preeti Chhabra, Andrew F. Marshall, Caleigh V. Morr, Blair T. Stocks, Emilee M. Hoopes, Rachel H. Bonami, Greg Poffenberger, Kenneth L. Brayman and Daniel J. Moore

Diabetes 2018 Nov; 67 (11): 2349-2360. https://doi.org/10.2337/db18-0456

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High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity
Wyatt J. McDonnell, John R. Koethe, Simon A. Mallal, Mark A. Pilkinton, Annet Kirabo, Magdalene K. Ameka, Matthew A. Cottam, Alyssa H. Hasty and Arion J. Kennedy

Diabetes 2018 Nov; 67 (11): 2361-2376. https://doi.org/10.2337/db18-0040

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Pathophysiology

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Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes
David W. Freeman, Nicole Noren Hooten, Erez Eitan, Jamal Green, Nicolle A. Mode, Monica Bodogai, Yongqing Zhang, Elin Lehrmann, Alan B. Zonderman, Arya Biragyn, Josephine Egan, Kevin G. Becker, Mark P. Mattson, Ngozi Ejiogu and Michele K. Evans

Diabetes 2018 Nov; 67 (11): 2377-2388. https://doi.org/10.2337/db17-1308

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Increased β-Cell Workload Modulates Proinsulin-to-Insulin Ratio in Humans
Teresa Mezza, Pietro M. Ferraro, Vinsin A. Sun, Simona Moffa, Chiara M.A. Cefalo, Giuseppe Quero, Francesca Cinti, Gian Pio Sorice, Alfredo Pontecorvi, Franco Folli, Andrea Mari, Sergio Alfieri and Andrea Giaccari

Diabetes 2018 Nov; 67 (11): 2389-2396. https://doi.org/10.2337/db18-0279

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The Dysfunctional MDM2–p53 Axis in Adipocytes Contributes to Aging-Related Metabolic Complications by Induction of Lipodystrophy
Zhuohao Liu, Leigang Jin, Jin-Kui Yang, Baile Wang, Kelvin K.L. Wu, Philip Hallenborg, Aimin Xu and Kenneth K.Y. Cheng

Diabetes 2018 Nov; 67 (11): 2397-2409. https://doi.org/10.2337/db18-0684

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Complications

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Glucagon-Like Peptide 1 and Its Cleavage Products Are Renoprotective in Murine Diabetic Nephropathy
Julia Moellmann, Barbara Mara Klinkhammer, Julia Onstein, Robert Stöhr, Vera Jankowski, Joachim Jankowski, Corinna Lebherz, Frank Tacke, Nikolaus Marx, Peter Boor and Michael Lehrke

Diabetes 2018 Nov; 67 (11): 2410-2419. https://doi.org/10.2337/db17-1212

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Podocyte-Specific Loss of Krüppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease
Sylvia J. Horne, Jessica M. Vasquez, Yiqing Guo, Victoria Ly, Sian E. Piret, Alexandra R. Leonardo, Jason Ling, Monica P. Revelo, Daniel Bogenhagen, Vincent W. Yang, John C. He and Sandeep K. Mallipattu

Diabetes 2018 Nov; 67 (11): 2420-2433. https://doi.org/10.2337/db17-0958

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A Systemic Inflammatory Signature Reflecting Cross Talk Between Innate and Adaptive Immunity Is Associated With Incident Polyneuropathy: KORA F4/FF4 Study
Christian Herder, Julia M. Kannenberg, Maren Carstensen-Kirberg, Alexander Strom, Gidon J. Bönhof, Wolfgang Rathmann, Cornelia Huth, Wolfgang Koenig, Margit Heier, Jan Krumsiek, Annette Peters, Christa Meisinger, Michael Roden, Barbara Thorand and Dan Ziegler

Diabetes 2018 Nov; 67 (11): 2434-2442. https://doi.org/10.2337/db18-0060

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The Dipeptidyl Peptidase 4 Substrate CXCL12 Has Opposing Cardiac Effects in Young Mice and Aged Diabetic Mice Mediated by Ca²⁺ Flux and Phosphoinositide 3-Kinase γ
Sri N. Batchu, Karina Thieme, Farigol H. Zadeh, Tamadher A. Alghamdi, Veera Ganesh Yerra, Mitchell J. Hadden, Syamantak Majumder, M. Golam Kabir, Bridgit B. Bowskill, Danyal Ladha, Anthony O. Gramolini, Kim A. Connelly and Andrew Advani

Diabetes 2018 Nov; 67 (11): 2443-2455. https://doi.org/10.2337/db18-0410

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Pharmacology and Therapeutics

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Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1
Katrin Pfuhlmann, Sonja C. Schriever, Peter Baumann, Dhiraj G. Kabra, Luke Harrison, Sithandiwe E. Mazibuko-Mbeje, Raian E. Contreras, Eleni Kyriakou, Stephanie E. Simonds, Tony Tiganis, Michael A. Cowley, Stephen C. Woods, Martin Jastroch, Christoffer Clemmensen, Meri De Angelis, Karl-Werner Schramm, Michael Sattler, Ana C. Messias, Matthias H. Tschöp and Paul T. Pfluger

Diabetes 2018 Nov; 67 (11): 2456-2465. https://doi.org/10.2337/db18-0146

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Genetics/Genomes/Proteomics/Metabolomics

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Type 2 Diabetes–Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets
Shubham Khetan, Romy Kursawe, Ahrim Youn, Nathan Lawlor, Alexandria Jillette, Eladio J. Marquez, Duygu Ucar and Michael L. Stitzel

Diabetes 2018 Nov; 67 (11): 2466-2477. https://doi.org/10.2337/db18-0393

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Expressions of Concern

Open Access
Expression of Concern. Kathrin Maedler, Desiree M. Schumann, Fabienne Schulthess, José Oberholzer, Domenico Bosco, Thierry Berney, and Marc Y. Donath. Aging Correlates With Decreased β-Cell Proliferative Capacity and Enhanced Sensitivity to Apoptosis: A Potential Role for Fas and Pancreatic Duodenal Homeobox-1. Diabetes 2006;55:2455–2462. DOI: 10.2337/db05-1586. PMID: 16936193
American Diabetes Association

Diabetes 2018 Nov; 67 (11): 2478-2479. https://doi.org/10.2337/db18-ec2018a

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Open Access
Update to Expression of Concern. Kathrin Maedler, Desiree M. Schumann, Nadine Sauter, Helga Ellingsgaard, Domenico Bosco, Reto Baertschiger, Yoichiro Iwakura, José Oberholzer, Claes B. Wollheim, Benoit R. Gauthier, and Marc Y. Donath. Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell Proliferation in Human Pancreatic Islets. Diabetes 2006;55:2713-2722. DOI:10.2337/db05-1430. PMID: 17003335
American Diabetes Association

Diabetes 2018 Nov; 67 (11): 2479-2480. https://doi.org/10.2337/db18-ec2018b

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Issues and Events

Open Access
Issues and Events
Diabetes 2018 Nov; 67 (11): 2481. https://doi.org/10.2337/db18-ie11

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Table of Contents

In This Issue

Perspectives in Diabetes

Commentaries

Metabolism

Signal Transduction

Obesity Studies

Islet Studies

Immunology and Transplantation

Pathophysiology

Complications

Pharmacology and Therapeutics

Genetics/Genomes/Proteomics/Metabolomics

Expressions of Concern

Issues and Events

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