A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study
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vol. 67 no. 2 334-342
PubMed
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History
- Received September 21, 2017
- Accepted November 7, 2017
- Published in print January 22, 2018.
- Published online ahead of print November 15, 2017.
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- Previous version (November 15, 2017 - 06:14).
- You are viewing the most recent version of this article.
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© 2017 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.
Author Information
- Aino Latva-Rasku1,
- Miikka-Juhani Honka1,
- Alena Stančáková2,
- Heikki A. Koistinen3,4,
- Johanna Kuusisto2,5,
- Li Guan6,
- Alisa K. Manning7,8,9,
- Heather Stringham6,
- Anna L. Gloyn10,11,12,
- Cecilia M. Lindgren7,10,13,
- T2D-GENES Consortium,
- Francis S. Collins14,
- Karen L. Mohlke15,
- Laura J. Scott6,
- Tomi Karjalainen1,
- Lauri Nummenmaa1,16,
- Michael Boehnke6⇑,
- Pirjo Nuutila1,17⇑ and
- Markku Laakso2,5⇑
- 1Turku PET Centre, University of Turku, Turku, Finland
- 2Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
- 3University of Helsinki and Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
- 4Minerva Foundation Institute for Medical Research, Helsinki, Finland
- 5Department of Medicine, Kuopio University Hospital, Kuopio, Finland
- 6Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI
- 7Program in Medical and Population Genetics, Broad Institute, Cambridge, MA
- 8Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA
- 9Department of Medicine, Harvard Medical School, Boston, MA
- 10Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, U.K.
- 11Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, U.K.
- 12National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, U.K.
- 13Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, U.K.
- 14National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
- 15Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC
- 16Department of Psychology, University of Turku, Finland
- 17Department of Endocrinology, Turku University Hospital, Turku, Finland
- Corresponding authors: Markku Laakso, markku.laakso{at}uef.fi, Pirjo Nuutila, pirjo.nuutila{at}utu.fi, and Michael Boehnke, boehnke{at}umich.edu.
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February 2018, 67(2)
A Partial Loss-of-Function Variant in AKT2 Is Associated With Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin-Sensitive Tissues: A Genotype-Based Callback Positron Emission Tomography Study
