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Complications

Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice

  1. Eleni Beli1,
  2. Yuanqing Yan2,
  3. Leni Moldovan3,
  4. Cristiano P. Vieira4,
  5. Ruli Gao5,
  6. Yaqian Duan6,
  7. Ram Prasad4,
  8. Ashay Bhatwadekar7,
  9. Fletcher A. White8,
  10. Steven D. Townsend9,
  11. Luisa Chan10,
  12. Caitlin N. Ryan10,
  13. Daniel Morton10,
  14. Emil G. Moldovan11,
  15. Fang-I Chu12,
  16. Gavin Y. Oudit13,
  17. Hartmut Derendorf14,
  18. Luciano Adorini15,
  19. Xiaoxin X. Wang16,
  20. Carmella Evans-Molina1,6,17,
  21. Raghavendra G. Mirmira1,6,17,
  22. Michael E. Boulton4,
  23. Mervin C. Yoder1,
  24. Qiuhong Li18,
  25. Moshe Levi16,
  26. Julia V. Busik19 and
  27. Maria B. Grant4⇑
  1. 1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN
  2. 2Department of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, TX
  3. 3Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
  4. 4Department of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, AL
  5. 5Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
  6. 6Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN
  7. 7Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  8. 8Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN
  9. 9Department of Chemistry, Vanderbilt University, Nashville, TN
  10. 10Second Genome, Inc., San Francisco, CA
  11. 11Northeastern University, Boston, MA
  12. 12Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA
  13. 13Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
  14. 14Department of Pharmaceutics, University of Florida, Gainesville, FL
  15. 15Intercept Pharmaceuticals, New York, NY
  16. 16Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC
  17. 17Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
  18. 18Department of Ophthalmology, University of Florida, Gainesville, FL
  19. 19Department of Physiology, Michigan State University, East Lansing, MI
  1. Corresponding author: Maria B. Grant, mariagrant{at}uabmc.edu.
  1. E.B. and Y.Y. contributed equally to the manuscript.

Diabetes 2018 Sep; 67(9): 1867-1879. https://doi.org/10.2337/db18-0158
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Article Information

vol. 67 no. 9 1867-1879
DOI 
https://doi.org/10.2337/db18-0158
PubMed 
29712667

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received February 7, 2018
  • Accepted April 18, 2018
  • Published in print August 22, 2018.
  • Published online ahead of print April 30, 2018.

Article Versions

  • Previous version (April 30, 2018 - 06:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2018 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

Author Information

  1. Eleni Beli1,
  2. Yuanqing Yan2,
  3. Leni Moldovan3,
  4. Cristiano P. Vieira4,
  5. Ruli Gao5,
  6. Yaqian Duan6,
  7. Ram Prasad4,
  8. Ashay Bhatwadekar7,
  9. Fletcher A. White8,
  10. Steven D. Townsend9,
  11. Luisa Chan10,
  12. Caitlin N. Ryan10,
  13. Daniel Morton10,
  14. Emil G. Moldovan11,
  15. Fang-I Chu12,
  16. Gavin Y. Oudit13,
  17. Hartmut Derendorf14,
  18. Luciano Adorini15,
  19. Xiaoxin X. Wang16,
  20. Carmella Evans-Molina1,6,17,
  21. Raghavendra G. Mirmira1,6,17,
  22. Michael E. Boulton4,
  23. Mervin C. Yoder1,
  24. Qiuhong Li18,
  25. Moshe Levi16,
  26. Julia V. Busik19 and
  27. Maria B. Grant4⇑
  1. 1Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN
  2. 2Department of Neurosurgery, The University of Texas Health Science Center at Houston, Houston, TX
  3. 3Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
  4. 4Department of Ophthalmology and Visual Sciences, University of Alabama, Birmingham, AL
  5. 5Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX
  6. 6Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN
  7. 7Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN
  8. 8Department of Anesthesia, Indiana University School of Medicine, Indianapolis, IN
  9. 9Department of Chemistry, Vanderbilt University, Nashville, TN
  10. 10Second Genome, Inc., San Francisco, CA
  11. 11Northeastern University, Boston, MA
  12. 12Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA
  13. 13Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
  14. 14Department of Pharmaceutics, University of Florida, Gainesville, FL
  15. 15Intercept Pharmaceuticals, New York, NY
  16. 16Department of Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC
  17. 17Department of Medicine, Indiana University School of Medicine, Indianapolis, IN
  18. 18Department of Ophthalmology, University of Florida, Gainesville, FL
  19. 19Department of Physiology, Michigan State University, East Lansing, MI
  1. Corresponding author: Maria B. Grant, mariagrant{at}uabmc.edu.
  1. E.B. and Y.Y. contributed equally to the manuscript.

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Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice
Eleni Beli, Yuanqing Yan, Leni Moldovan, Cristiano P. Vieira, Ruli Gao, Yaqian Duan, Ram Prasad, Ashay Bhatwadekar, Fletcher A. White, Steven D. Townsend, Luisa Chan, Caitlin N. Ryan, Daniel Morton, Emil G. Moldovan, Fang-I Chu, Gavin Y. Oudit, Hartmut Derendorf, Luciano Adorini, Xiaoxin X. Wang, Carmella Evans-Molina, Raghavendra G. Mirmira, Michael E. Boulton, Mervin C. Yoder, Qiuhong Li, Moshe Levi, Julia V. Busik, Maria B. Grant
Diabetes Sep 2018, 67 (9) 1867-1879; DOI: 10.2337/db18-0158

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Restructuring of the Gut Microbiome by Intermittent Fasting Prevents Retinopathy and Prolongs Survival in db/db Mice
Eleni Beli, Yuanqing Yan, Leni Moldovan, Cristiano P. Vieira, Ruli Gao, Yaqian Duan, Ram Prasad, Ashay Bhatwadekar, Fletcher A. White, Steven D. Townsend, Luisa Chan, Caitlin N. Ryan, Daniel Morton, Emil G. Moldovan, Fang-I Chu, Gavin Y. Oudit, Hartmut Derendorf, Luciano Adorini, Xiaoxin X. Wang, Carmella Evans-Molina, Raghavendra G. Mirmira, Michael E. Boulton, Mervin C. Yoder, Qiuhong Li, Moshe Levi, Julia V. Busik, Maria B. Grant
Diabetes Sep 2018, 67 (9) 1867-1879; DOI: 10.2337/db18-0158
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