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Sex Hormone–Binding Globulin, Cardiometabolic Biomarkers, and Gestational Diabetes—A Longitudinal Pregnancy Cohort Study and a Meta-analysis

  1. MENGYING LI,
  2. SHRISTI RAWAL,
  3. STEFANIE HINKLE,
  4. SIMIN LIU,
  5. FASIL TEKOLA-AYELE and
  6. CUILIN ZHANG
  1. Bethesda, MD, Newark, NJ, Providence, RI
Diabetes 2018 Jul; 67(Supplement 1): -. https://doi.org/10.2337/db18-1434-P
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Abstract

Background: Sex hormone-binding globulin (SHBG) has been implicated in glucose metabolism and the development of type 2 diabetes. However, its role in glucose metabolism during pregnancy is unclear.

Objectives: This study investigated the prospective associations of SHBG with cardiometabolic biomarkers during pregnancy and gestational diabetes (GDM) risk.

Methods: We conducted a nested case-control study of 107 GDM cases and 214 matched controls without GDM in the NICHD Fetal Growth Studies-Singleton Cohort. GDM was ascertained by medical record review. Blood samples were drawn at 10-14, 15-26, 23-31 and 33-39 gestational weeks (GW). Prospective associations of SHBG with cardiometabolic biomarkers were estimated using Spearman’s correlation coefficient adjusting for potential confounders. Difference in SHBG levels between GDM and non-GDM women was estimated in the present study cohort and a meta-analysis of existing prospective evidence. Odds ratios (OR) for GDM by SHBG quartiles were estimated using conditional logistic regression.

Results: SHBG at GW 10-14 was significantly and inversely related to fasting glucose, fasting insulin, insulin resistance and HbA1c levels, and positively related to high-density lipoprotein and cholesterol levels at GW 15-26. Cases had lower SHBG levels compared to controls at GW 10-14 (mean ± SD: 204.0 ± 97.6 vs. 220.9 ± 102.5 nmol/L) and 15-26 (305.6 ± 124.3 vs. 322.7 ± 105.1 nmol/L), yet the differences were not significant. Meta-analysis of 11 prospective studies, including ours, estimated SHBG levels to be 0.50 SD (95% CI: 0.36-0.65) lower among women with than without GDM.

Conclusions: Higher SHBG levels in early pregnancy was associated with a favorable glucose metabolic profile among pregnant women. Synthesis of prospective studies supports an inverse association between SHBG levels and GDM risk.

Disclosure M. Li: None. S. Rawal: None. S. Hinkle: None. S. Liu: None. F. Tekola-Ayele: None. C. Zhang: None.

  • © 2018 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Diabetes: 67 (Supplement 1)

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July 2018, 67(Supplement 1)
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Sex Hormone–Binding Globulin, Cardiometabolic Biomarkers, and Gestational Diabetes—A Longitudinal Pregnancy Cohort Study and a Meta-analysis
MENGYING LI, SHRISTI RAWAL, STEFANIE HINKLE, SIMIN LIU, FASIL TEKOLA-AYELE, CUILIN ZHANG
Diabetes Jul 2018, 67 (Supplement 1) 1434-P; DOI: 10.2337/db18-1434-P

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Sex Hormone–Binding Globulin, Cardiometabolic Biomarkers, and Gestational Diabetes—A Longitudinal Pregnancy Cohort Study and a Meta-analysis
MENGYING LI, SHRISTI RAWAL, STEFANIE HINKLE, SIMIN LIU, FASIL TEKOLA-AYELE, CUILIN ZHANG
Diabetes Jul 2018, 67 (Supplement 1) 1434-P; DOI: 10.2337/db18-1434-P
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