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General Poster Session

The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans

  1. FRANCESCA CINTI,
  2. ILENIA SEVERI,
  3. MARA SULEIMAN,
  4. LORELLA MARSELLI,
  5. PIERO MARCHETTI,
  6. SAVERIO CINTI and
  7. DOMENICO ACCILI
  1. Rome, Italy, Ancona, Italy, Pisa, Italy, New York, NY
Diabetes 2018 Jul; 67(Supplement 1): -. https://doi.org/10.2337/db18-2142-P
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Abstract

β cells dedifferentiation has been recently introduced as the main mechanism responsible for the functional “disappearance” of β cells from the islands of diabetic subjects. Starting from results obtained from a mouse model of type 2 (T2) diabetes (in whose a significant increase in density of noradrenergic fibers was detected compared to nondiabetic mice), we asked if the result could be replicated in humans and if it could be related to the process of dedifferentiation. Human pancreas of 8 healthy donors and 9 with T2 diabetes were analyzed by immunohistochemistry (M / F 4/4 vs. 5/4 NS; BMI (kg / m2) 24.8 ± 2.8 vs. 25.6 ± 4.1; NS). The dedifferentiation score was calculated as % of cells synaptophysin positive but negative for the four major pancreatic hormones. Tyrosine hydroxylase (TH) was used as a marker for the evaluation of noradrenergic fiber expression. The islands of diabetic subjects were about 3 times more innervated than controls (0.42 ± 0.51 vs. 1.66 ± 2.2 n.fibersTH +/island; p = 0.02); the increase of these fibers correlated positively with the dedifferentiation score (p <0.001; r = 0.69).

In conclusion, our data show an increase in the number of sympathetic nerve fibers potentially able to transmit inhibitory signals on insulin secretion in the islands of diabetic subjects. The important correlation with the dedifferentiation score suggests a significant role of noradrenergic fibers in the pathogenesis of the dedifferentiation process, introducing new strategies for the preservation of cellular mass/secretion and, therefore, for the prevention and treatment of T2 diabetes.

Disclosure F. Cinti: None. I. Severi: None. M. Suleiman: None. L. Marselli: None. P. Marchetti: None. S. Cinti: None. D. Accili: None.

  • © 2018 by the American Diabetes Association.
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Diabetes: 67 (Supplement 1)

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July 2018, 67(Supplement 1)
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The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans
FRANCESCA CINTI, ILENIA SEVERI, MARA SULEIMAN, LORELLA MARSELLI, PIERO MARCHETTI, SAVERIO CINTI, DOMENICO ACCILI
Diabetes Jul 2018, 67 (Supplement 1) 2142-P; DOI: 10.2337/db18-2142-P

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The Increment of Noradrenergic Fibers Correlates with the Density of Dedifferentiated ß Cells in Humans
FRANCESCA CINTI, ILENIA SEVERI, MARA SULEIMAN, LORELLA MARSELLI, PIERO MARCHETTI, SAVERIO CINTI, DOMENICO ACCILI
Diabetes Jul 2018, 67 (Supplement 1) 2142-P; DOI: 10.2337/db18-2142-P
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