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Metabolism

Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food

  1. Marie K. Holt1,
  2. James E. Richards1,
  3. Daniel R. Cook1,
  4. Daniel I. Brierley1,
  5. Diana L. Williams2,
  6. Frank Reimann3,
  7. Fiona M. Gribble3 and
  8. Stefan Trapp1⇑
  1. 1Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, U.K.
  2. 2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL
  3. 3Institute of Metabolic Science and MRC Metabolic Diseases Unit, Addenbrooke’s Hospital, University of Cambridge, Cambridge, U.K.
  1. Corresponding author: Stefan Trapp, s.trapp{at}ucl.ac.uk
  1. M.K.H. and J.E.R. contributed equally to the work.

Diabetes 2019 Jan; 68(1): 21-33. https://doi.org/10.2337/db18-0729
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Article Information

vol. 68 no. 1 21-33
DOI 
https://doi.org/10.2337/db18-0729
PubMed 
30279161

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received July 9, 2018
  • Accepted September 21, 2018
  • Published in print December 20, 2018.
  • Published online ahead of print October 2, 2018.

Article Versions

  • Previous version (October 2, 2018 - 07:22).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2018 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

Author Information

  1. Marie K. Holt1,
  2. James E. Richards1,
  3. Daniel R. Cook1,
  4. Daniel I. Brierley1,
  5. Diana L. Williams2,
  6. Frank Reimann3,
  7. Fiona M. Gribble3 and
  8. Stefan Trapp1⇑
  1. 1Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, U.K.
  2. 2Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL
  3. 3Institute of Metabolic Science and MRC Metabolic Diseases Unit, Addenbrooke’s Hospital, University of Cambridge, Cambridge, U.K.
  1. Corresponding author: Stefan Trapp, s.trapp{at}ucl.ac.uk
  1. M.K.H. and J.E.R. contributed equally to the work.

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Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food
Marie K. Holt, James E. Richards, Daniel R. Cook, Daniel I. Brierley, Diana L. Williams, Frank Reimann, Fiona M. Gribble, Stefan Trapp
Diabetes Jan 2019, 68 (1) 21-33; DOI: 10.2337/db18-0729

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Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food
Marie K. Holt, James E. Richards, Daniel R. Cook, Daniel I. Brierley, Diana L. Williams, Frank Reimann, Fiona M. Gribble, Stefan Trapp
Diabetes Jan 2019, 68 (1) 21-33; DOI: 10.2337/db18-0729
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