Diabetes: 68 (12)

December 01 2019; volume 68 issue 12

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Open Access
In This Issue of Diabetes
Diabetes 2019 Dec; 68 (12): 2193-2194. https://doi.org/10.2337/db19-ti12

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Commentary

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New Antidiabetes Agent Targeting Both Mitochondrial Uncoupling and Pyruvate Catabolism: Two Birds With One Stone
Liangyou Rui

Diabetes 2019 Dec; 68 (12): 2195-2196. https://doi.org/10.2337/dbi19-0024

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Metabolism

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Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li and Jia Li

Diabetes 2019 Dec; 68 (12): 2197-2209. https://doi.org/10.2337/db19-0589

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MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance
Omar Al-Massadi, Mar Quiñones, Jerome Clasadonte, René Hernandez-Bautista, Amparo Romero-Picó, Cintia Folgueira, Donald A. Morgan, Imre Kalló, Violeta Heras, Ana Senra, Samuel C. Funderburk, Michael J. Krashes, Yara Souto, Miguel Fidalgo, Serge Luquet, Melissa J. Chee, Monica Imbernon, Daniel Beiroa, Lucía García-Caballero, Rosalia Gallego, Brian Y.H. Lam, Giles Yeo, Miguel Lopez, Zsolt Liposits, Kamal Rahmouni, Vincent Prevot, Carlos Dieguez and Ruben Nogueiras

Diabetes 2019 Dec; 68 (12): 2210-2222. https://doi.org/10.2337/db19-0029

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The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1
Daniela Herrera Moro Chao, Yanan Wang, Ewout Foppen, Roelof Ottenhoff, Cindy van Roomen, Edwin T. Parlevliet, Marco van Eijk, Marri Verhoek, Rolf Boot, Andre R. Marques, Saskia Scheij, Mina Mirzaian, Sander Kooijman, Kirstin Jansen, Dawei Wang, Clarita Mergen, Randy J. Seeley, Matthias H. Tschöp, Herman Overkleeft, Patrick C.N. Rensen, Andries Kalsbeek, Johannes M.F.G. Aerts and Chun-Xia Yi

Diabetes 2019 Dec; 68 (12): 2223-2234. https://doi.org/10.2337/db19-0049

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Obesity Studies

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Evaluation of the Genetic Association Between Adult Obesity and Neuropsychiatric Disease
Priska Stahel, Avital Nahmias, Shawn K. Sud, So Jeong Lee, Andrea Pucci, Ahmed Yousseif, Alaa Youseff, Timothy Jackson, David R. Urbach, Allan Okrainec, Johane P. Allard, Sanjeev Sockalingam, Tony Yao, Moumita Barua, Hong Jiao, Reedik Magi, Anne S. Bassett, Andrew D. Paterson, Ingrid Dahlman, Rachel L. Batterham and Satya Dash

Diabetes 2019 Dec; 68 (12): 2235-2246. https://doi.org/10.2337/db18-1254

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Subcutaneous Adipose Tissue and Systemic Inflammation Are Associated With Peripheral but Not Hepatic Insulin Resistance in Humans
Birgitta W. van der Kolk, Marianthi Kalafati, Michiel Adriaens, Marleen M.J. van Greevenbroek, Nicole Vogelzangs, Wim H.M. Saris, Arne Astrup, Armand Valsesia, Dominique Langin, Carla J.H. van der Kallen, Simone J.P.M. Eussen, Casper G. Schalkwijk, Coen D.A. Stehouwer, Gijs H. Goossens, Ilja C.W. Arts, Johan W.E. Jocken, Chris T. Evelo and Ellen E. Blaak

Diabetes 2019 Dec; 68 (12): 2247-2258. https://doi.org/10.2337/db19-0560

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Islet Studies

Open Access
Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell–Derived Insulin-Expressing Cells Require NEUROD1
Anthony I. Romer, Ruth A. Singer, Lina Sui, Dieter Egli and Lori Sussel

Diabetes 2019 Dec; 68 (12): 2259-2271. https://doi.org/10.2337/db19-0117

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Metabolomics Identifies a Biomarker Revealing In Vivo Loss of Functional β-Cell Mass Before Diabetes Onset
Lingzi Li, Petra Krznar, Alexander Erban, Andrea Agazzi, Juliette Martin-Levilain, Sachin Supale, Joachim Kopka, Nicola Zamboni and Pierre Maechler

Diabetes 2019 Dec; 68 (12): 2272-2286. https://doi.org/10.2337/db19-0131

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Complications

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Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2
Barend W. Florijn, Jacques M.G.J. Duijs, Johannes H. Levels, Geesje M. Dallinga-Thie, Yanan Wang, Anita N. Boing, Yuana Yuana, Wendy Stam, Ronald W.A.L. Limpens, Yu Wah Au, Rienk Nieuwland, Ton J. Rabelink, Marlies E.J. Reinders, Anton Jan van Zonneveld and Roel Bijkerk

Diabetes 2019 Dec; 68 (12): 2287-2300. https://doi.org/10.2337/db18-1360

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Open Access
Comparison of Kidney Transcriptomic Profiles of Early and Advanced Diabetic Nephropathy Reveals Potential New Mechanisms for Disease Progression
Ying Fan, Zhengzi Yi, Vivette D. D’Agati, Zeguo Sun, Fang Zhong, Weijia Zhang, Jiejun Wen, Ting Zhou, Ze Li, Li He, Qunzi Zhang, Kyung Lee, John Cijiang He and Niansong Wang

Diabetes 2019 Dec; 68 (12): 2301-2314. https://doi.org/10.2337/db19-0204

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Genetics/Genomes/Proteomics/Metabolomics

Open Access
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study
Alexia Cardona, Felix R. Day, John R.B. Perry, Marie Loh, Audrey Y. Chu, Benjamin Lehne, Dirk S. Paul, Luca A. Lotta, Isobel D. Stewart, Nicola D. Kerrison, Robert A. Scott, Kay-Tee Khaw, Nita G. Forouhi, Claudia Langenberg, Chunyu Liu, Michael M. Mendelson, Daniel Levy, Stephan Beck, R. David Leslie, Josée Dupuis, James B. Meigs, Jaspal S. Kooner, Jussi Pihlajamäki, Allan Vaag, Alexander Perfilyev, Charlotte Ling, Marie-France Hivert, John C. Chambers, Nicholas J. Wareham and Ken K. Ong

Diabetes 2019 Dec; 68 (12): 2315-2326. https://doi.org/10.2337/db18-0290

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Open Access
Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study
Ruifang Li-Gao, Françoise Carlotti, Renée de Mutsert, Astrid van Hylckama Vlieg, Eelco J.P. de Koning, J. Wouter Jukema, Frits R. Rosendaal, Ko Willems van Dijk and Dennis O. Mook-Kanamori

Diabetes 2019 Dec; 68 (12): 2327-2336. https://doi.org/10.2337/db19-0378

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Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program
Zsu-Zsu Chen, Jinxi Liu, Jordan Morningstar, Brandy M. Heckman-Stoddard, Christine G. Lee, Samuel Dagogo-Jack, Jane F. Ferguson, Richard F. Hamman, William C. Knowler, Kieren J. Mather, Leigh Perreault, Jose C. Florez, Thomas J. Wang, Clary Clish, Marinella Temprosa, Robert E. Gerszten and the Diabetes Prevention Program Research Group

Diabetes 2019 Dec; 68 (12): 2337-2349. https://doi.org/10.2337/db19-0236

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Erratum

Open Access
Erratum. Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes. Diabetes 2019;68:1709–1716
Richard N. Bergman, Francesca Piccinini, Morvarid Kabir, Cathryn M. Kolka and Marilyn Ader

Diabetes 2019 Dec; 68 (12): 2350. https://doi.org/10.2337/db19-er12a

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Issues and Events

Open Access
Issues and Events
Diabetes 2019 Dec; 68 (12): 2351. https://doi.org/10.2337/db19-ie12

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In This Issue

Commentary

Metabolism

Obesity Studies

Islet Studies

Complications

Genetics/Genomes/Proteomics/Metabolomics

Erratum

Issues and Events

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