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Genetics/Genomes/Proteomics/Metabolomics

Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families

  1. Markus Hippich1,
  2. Andreas Beyerlein1,2,
  3. William A. Hagopian3,
  4. Jeffrey P. Krischer4,
  5. Kendra Vehik4,
  6. Jan Knoop1,
  7. Christiane Winker1,5,
  8. Jorma Toppari6,
  9. Åke Lernmark7,
  10. Marian J. Rewers8,
  11. Andrea K. Steck8,
  12. Jin-Xiong She9,
  13. Beena Akolkar10,
  14. Catherine C. Robertson11,
  15. Suna Onengut-Gumuscu11,
  16. Stephen S. Rich11,
  17. Ezio Bonifacio5,12⇑,
  18. Anette-G. Ziegler1,2,5⇑,
  19. the TEDDY Study Group*
  1. 1Institute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany
  2. 2Forschergruppe Diabetes, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
  3. 3Pacific Northwest Research Institute, Seattle, WA
  4. 4Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL
  5. 5Forschergruppe Diabetes e.V., Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany
  6. 6Department of Pediatrics, Turku University Hospital, and Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
  7. 7Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmo, Sweden
  8. 8Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO
  9. 9Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA
  10. 10National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
  11. 11Center for Public Health Genomics, University of Virginia, Charlottesville, VA
  12. 12DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
  1. Corresponding authors: Anette-G. Ziegler, anette-g.ziegler{at}helmholtz-muenchen.de, and Ezio Bonifacio, ezio.bonifacio{at}tu-dresden.de
    Diabetes 2019 Apr; 68(4): 847-857. https://doi.org/10.2337/db18-0882
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    Article Information

    vol. 68 no. 4 847-857
    DOI 
    https://doi.org/10.2337/db18-0882
    PubMed 
    30655385

    Published By 
    American Diabetes Association
    Print ISSN 
    0012-1797
    Online ISSN 
    1939-327X
    History 
    • Received August 16, 2018
    • Accepted January 4, 2019
    • Published in print March 20, 2019.
    • Published online ahead of print January 17, 2019.

    Article Versions

    • Previous version (January 17, 2019 - 12:30).
    • Previous version (January 23, 2019 - 07:02).
    • You are viewing the most recent version of this article.
    Copyright & Usage 
    © 2019 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

    Author Information

    1. Markus Hippich1,
    2. Andreas Beyerlein1,2,
    3. William A. Hagopian3,
    4. Jeffrey P. Krischer4,
    5. Kendra Vehik4,
    6. Jan Knoop1,
    7. Christiane Winker1,5,
    8. Jorma Toppari6,
    9. Åke Lernmark7,
    10. Marian J. Rewers8,
    11. Andrea K. Steck8,
    12. Jin-Xiong She9,
    13. Beena Akolkar10,
    14. Catherine C. Robertson11,
    15. Suna Onengut-Gumuscu11,
    16. Stephen S. Rich11,
    17. Ezio Bonifacio5,12⇑,
    18. Anette-G. Ziegler1,2,5⇑,
    19. the TEDDY Study Group*
    1. 1Institute of Diabetes Research, Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany
    2. 2Forschergruppe Diabetes, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    3. 3Pacific Northwest Research Institute, Seattle, WA
    4. 4Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL
    5. 5Forschergruppe Diabetes e.V., Helmholtz Zentrum München (German Research Center for Environmental Health), Munich-Neuherberg, Germany
    6. 6Department of Pediatrics, Turku University Hospital, and Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
    7. 7Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Malmo, Sweden
    8. 8Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO
    9. 9Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA
    10. 10National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD
    11. 11Center for Public Health Genomics, University of Virginia, Charlottesville, VA
    12. 12DFG Center for Regenerative Therapies Dresden, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
    1. Corresponding authors: Anette-G. Ziegler, anette-g.ziegler{at}helmholtz-muenchen.de, and Ezio Bonifacio, ezio.bonifacio{at}tu-dresden.de
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      Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
      Markus Hippich, Andreas Beyerlein, William A. Hagopian, Jeffrey P. Krischer, Kendra Vehik, Jan Knoop, Christiane Winker, Jorma Toppari, Åke Lernmark, Marian J. Rewers, Andrea K. Steck, Jin-Xiong She, Beena Akolkar, Catherine C. Robertson, Suna Onengut-Gumuscu, Stephen S. Rich, Ezio Bonifacio, Anette-G. Ziegler, the TEDDY Study Group
      Diabetes Apr 2019, 68 (4) 847-857; DOI: 10.2337/db18-0882

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      Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families
      Markus Hippich, Andreas Beyerlein, William A. Hagopian, Jeffrey P. Krischer, Kendra Vehik, Jan Knoop, Christiane Winker, Jorma Toppari, Åke Lernmark, Marian J. Rewers, Andrea K. Steck, Jin-Xiong She, Beena Akolkar, Catherine C. Robertson, Suna Onengut-Gumuscu, Stephen S. Rich, Ezio Bonifacio, Anette-G. Ziegler, the TEDDY Study Group
      Diabetes Apr 2019, 68 (4) 847-857; DOI: 10.2337/db18-0882
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