Diabetes: 68 (9)

September 01 2019; volume 68 issue 9

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In This Issue of Diabetes
Diabetes 2019 Sep; 68 (9): 1707-1708. https://doi.org/10.2337/db19-ti09

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Perspectives in Diabetes

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Hypothesis: Role of Reduced Hepatic Insulin Clearance in the Pathogenesis of Type 2 Diabetes
Richard N. Bergman, Francesca Piccinini, Morvarid Kabir, Cathryn M. Kolka and Marilyn Ader

Diabetes 2019 Sep; 68 (9): 1709-1716. https://doi.org/10.2337/db19-0098

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Metabolism

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A Thermogenic-Like Brown Adipose Tissue Phenotype Is Dispensable for Enhanced Glucose Tolerance in Female Mice
Nathan C. Winn, Rebeca Acin-Perez, Makenzie L. Woodford, Sarah A. Hansen, Megan M. Haney, Lolade A. Ayedun, R. Scott Rector, Victoria J. Vieira-Potter, Orian S. Shirihai, Harold S. Sacks, Jill A. Kanaley and Jaume Padilla

Diabetes 2019 Sep; 68 (9): 1717-1729. https://doi.org/10.2337/db18-1070

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Open Access
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
Meiyi Zhou, Jing Shao, Cheng-Yang Wu, Le Shu, Weibing Dong, Yunxia Liu, Mengping Chen, R. Max Wynn, Jiqiu Wang, Ji Wang, Wen-Jun Gui, Xiangbing Qi, Aldons J. Lusis, Zhaoping Li, Weiqing Wang, Guang Ning, Xia Yang, David T. Chuang, Yibin Wang and Haipeng Sun

Diabetes 2019 Sep; 68 (9): 1730-1746. https://doi.org/10.2337/db18-0927

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Assessment of Causal Direction Between Gut Microbiota–Dependent Metabolites and Cardiometabolic Health: A Bidirectional Mendelian Randomization Analysis
Jinzhu Jia, Pan Dou, Meng Gao, Xuejun Kong, Changwei Li, Zhonghua Liu and Tao Huang

Diabetes 2019 Sep; 68 (9): 1747-1755. https://doi.org/10.2337/db19-0153

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TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction
Rasmus Kjøbsted, Alexandra Chadt, Nicolas O. Jørgensen, Kohei Kido, Jeppe K. Larsen, Christian de Wendt, Hadi Al-Hasani and Jørgen F.P. Wojtaszewski

Diabetes 2019 Sep; 68 (9): 1756-1766. https://doi.org/10.2337/db18-0769

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Obesity Studies

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Unconventional Secretion of Adipocyte Fatty Acid Binding Protein 4 Is Mediated By Autophagic Proteins in a Sirtuin-1–Dependent Manner
Ajeetha Josephrajan, Ann V. Hertzel, Ellie K. Bohm, Michael W. McBurney, Shin-Ichiro Imai, Douglas G. Mashek, Do-Hyung Kim and David A. Bernlohr

Diabetes 2019 Sep; 68 (9): 1767-1777. https://doi.org/10.2337/db18-1367

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Islet Studies

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Differential Effect of Glucose on ER-Mitochondria Ca²⁺ Exchange Participates in Insulin Secretion and Glucotoxicity-Mediated Dysfunction of β-Cells
Florian Dingreville, Baptiste Panthu, Charles Thivolet, Sylvie Ducreux, Yves Gouriou, Sandra Pesenti, Marie-Agnès Chauvin, Karim Chikh, Elisabeth Errazuriz-Cerda, Fabien Van Coppenolle, Jennifer Rieusset and Anne-Marie Madec

Diabetes 2019 Sep; 68 (9): 1778-1794. https://doi.org/10.2337/db18-1112

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Intraislet Ghrelin Signaling Does Not Regulate Insulin Secretion From Adult Mice
Sarah M. Gray, Jingjing Niu, Amanda Zhang, Berit Svendsen, Jonathan E. Campbell, David A. D’Alessio and Jenny Tong

Diabetes 2019 Sep; 68 (9): 1795-1805. https://doi.org/10.2337/db19-0079

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The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
Jason M. Spaeth, Jin-Hua Liu, Daniel Peters, Min Guo, Anna B. Osipovich, Fardin Mohammadi, Nilotpal Roy, Anil Bhushan, Mark A. Magnuson, Matthias Hebrok, Christopher V.E. Wright and Roland Stein

Diabetes 2019 Sep; 68 (9): 1806-1818. https://doi.org/10.2337/db19-0349

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Immunology and Transplantation

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Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes
Maria J. Acevedo-Calado, Susan L. Pietropaolo, Michael P. Morran, Santiago Schnell, Andrew D. Vonberg, Charles F. Verge, Roberto Gianani, Dorothy J. Becker, Shuai Huang, Carla J. Greenbaum, Liping Yu, Howard W. Davidson, Aaron W. Michels, Stephen S. Rich and Massimo Pietropaolo, for the Type 1 Diabetes TrialNet Study Group

Diabetes 2019 Sep; 68 (9): 1819-1829. https://doi.org/10.2337/db18-1351

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Hybrid Insulin Peptides Are Autoantigens in Type 1 Diabetes
Rocky L. Baker, Marynette Rihanek, Anita C. Hohenstein, Maki Nakayama, Aaron Michels, Peter A. Gottlieb, Kathryn Haskins and Thomas Delong

Diabetes 2019 Sep; 68 (9): 1830-1840. https://doi.org/10.2337/db19-0128

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Complications

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Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature
Ivan Hernandez-Diaz, Jiaqi Pan, Carlo Alberto Ricciardi, Xiaoyan Bai, Jianting Ke, Kathryn E. White, Maria Flaquer, Georgia E. Fouli, Fulye Argunhan, Anthea E. Hayward, Fan Fan Hou, Giovanni E. Mann, Robert Q. Miao, David A. Long and Luigi Gnudi

Diabetes 2019 Sep; 68 (9): 1841-1852. https://doi.org/10.2337/db19-0157

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Immune Complexes and the Risk of CVD in Type 1 Diabetes
Maria F. Lopes-Virella, Ionut Bebu, Kelly J. Hunt, Gabriel Virella, Nathaniel L. Baker, Barbara Braffett, Xiaoyu Gao, John M. Lachin and the DCCT/EDIC Research Group*

Diabetes 2019 Sep; 68 (9): 1853-1860. https://doi.org/10.2337/db19-0358

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Association of Baseline Hyperglycemia With Outcomes of Patients With and Without Diabetes With Acute Ischemic Stroke Treated With Intravenous Thrombolysis: A Propensity Score–Matched Analysis From the SITS-ISTR Registry
Georgios Tsivgoulis, Aristeidis H. Katsanos, Dimitris Mavridis, Vaia Lambadiari, Christine Roffe, Mary Joan Macleod, Petr Sevcik, Manuel Cappellari, Miroslava Nevšímalová, Danilo Toni and Niaz Ahmed

Diabetes 2019 Sep; 68 (9): 1861-1869. https://doi.org/10.2337/db19-0440

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Issues and Events

Open Access
Issues and Events
Diabetes 2019 Sep; 68 (9): 1870. https://doi.org/10.2337/db19-ie09

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Perspectives in Diabetes

Metabolism

Obesity Studies

Islet Studies

Immunology and Transplantation

Complications

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