On the cover: This homage to Jackson Pollock shows a layered snapshot of the predicted three-dimensional structural models for the native and variant IA-2 protein. In this issue of Diabetes, Acevedo-Calado et al. show that antibodies to the variant IA-2 protein are associated with a high risk of type 1 diabetes progression in their article, “Autoantibodies Directed Toward a Novel IA-2 Variant Protein Enhance Prediction of Type 1 Diabetes” (p. 1819). Image courtesy of Santiago Schnell, Department of Molecular & Integrative Physiology and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI.