Skip to main content
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care
  • Subscribe
  • Log in
  • My Cart
  • Follow ada on Twitter
  • RSS
  • Visit ada on Facebook
Diabetes

Advanced Search

Main menu

  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
  • More from ADA
    • Diabetes Care
    • Clinical Diabetes
    • Diabetes Spectrum
    • ADA Standards of Medical Care in Diabetes
    • ADA Scientific Sessions Abstracts
    • BMJ Open Diabetes Research & Care

User menu

  • Subscribe
  • Log in
  • My Cart

Search

  • Advanced search
Diabetes
  • Home
  • Current
    • Current Issue
    • Online Ahead of Print
    • ADA Scientific Sessions Abstracts
  • Browse
    • By Topic
    • Issue Archive
    • Saved Searches
    • ADA Scientific Sessions Abstracts
    • Diabetes COVID-19 Article Collection
    • Diabetes Symposium 2020
  • Info
    • About the Journal
    • About the Editors
    • ADA Journal Policies
    • Instructions for Authors
    • Guidance for Reviewers
  • Reprints/Reuse
  • Advertising
  • Subscriptions
    • Individual Subscriptions
    • Institutional Subscriptions and Site Licenses
    • Access Institutional Usage Reports
    • Purchase Single Issues
  • Alerts
    • E­mail Alerts
    • RSS Feeds
  • Podcasts
    • Diabetes Core Update
    • Special Podcast Series: Therapeutic Inertia
    • Special Podcast Series: Influenza Podcasts
    • Special Podcast Series: SGLT2 Inhibitors
    • Special Podcast Series: COVID-19
  • Submit
    • Submit a Manuscript
    • Submit Cover Art
    • ADA Journal Policies
    • Instructions for Authors
    • ADA Peer Review
Metabolism

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance

  1. Meiyi Zhou1,
  2. Jing Shao1,
  3. Cheng-Yang Wu2,
  4. Le Shu3,
  5. Weibing Dong1,
  6. Yunxia Liu1,
  7. Mengping Chen1,
  8. R. Max Wynn2,
  9. Jiqiu Wang4,
  10. Ji Wang1,
  11. Wen-Jun Gui2,
  12. Xiangbing Qi5,
  13. Aldons J. Lusis6,
  14. Zhaoping Li7,
  15. Weiqing Wang4,
  16. Guang Ning4,
  17. Xia Yang3,
  18. David T. Chuang2,
  19. Yibin Wang8 and
  20. Haipeng Sun1,8⇑
  1. 1Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. 2Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX
  3. 3Department of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, CA
  4. 4Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  5. 5Chemistry Center, National Institute of Biological Science, Beijing, China
  6. 6Departments of Medicine, Microbiology, and Human Genetics, University of California at Los Angeles, Los Angeles, CA
  7. 7Department of Clinical Nutrition, University of California at Los Angeles, Los Angeles, CA
  8. 8Departments of Anesthesiology, Medicine, and Physiology, University of California at Los Angeles, Los Angeles, CA
  1. Corresponding author: Haipeng Sun, sun.haipeng{at}yahoo.com
  1. M.Z., J.S., C.-Y.W., and L.S. contributed equally to this work.

Diabetes 2019 Sep; 68(9): 1730-1746. https://doi.org/10.2337/db18-0927
PreviousNext
  • Article
  • Figures & Tables
  • Suppl Material
  • Info & Metrics
  • PDF
Loading

Article Information

vol. 68 no. 9 1730-1746
DOI 
https://doi.org/10.2337/db18-0927
PubMed 
31167878

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received August 26, 2018
  • Accepted May 29, 2019
  • Published in print August 20, 2019.
  • Published online ahead of print June 5, 2019.

Article Versions

  • Previous version (June 5, 2019 - 13:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2019 by the American Diabetes Association. http://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

Author Information

  1. Meiyi Zhou1,
  2. Jing Shao1,
  3. Cheng-Yang Wu2,
  4. Le Shu3,
  5. Weibing Dong1,
  6. Yunxia Liu1,
  7. Mengping Chen1,
  8. R. Max Wynn2,
  9. Jiqiu Wang4,
  10. Ji Wang1,
  11. Wen-Jun Gui2,
  12. Xiangbing Qi5,
  13. Aldons J. Lusis6,
  14. Zhaoping Li7,
  15. Weiqing Wang4,
  16. Guang Ning4,
  17. Xia Yang3,
  18. David T. Chuang2,
  19. Yibin Wang8 and
  20. Haipeng Sun1,8⇑
  1. 1Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. 2Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX
  3. 3Department of Integrative Biology and Physiology, University of California at Los Angeles, Los Angeles, CA
  4. 4Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  5. 5Chemistry Center, National Institute of Biological Science, Beijing, China
  6. 6Departments of Medicine, Microbiology, and Human Genetics, University of California at Los Angeles, Los Angeles, CA
  7. 7Department of Clinical Nutrition, University of California at Los Angeles, Los Angeles, CA
  8. 8Departments of Anesthesiology, Medicine, and Physiology, University of California at Los Angeles, Los Angeles, CA
  1. Corresponding author: Haipeng Sun, sun.haipeng{at}yahoo.com
  1. M.Z., J.S., C.-Y.W., and L.S. contributed equally to this work.

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: to

Rendering graph...
AbstractFullPdf

PreviousNext
Back to top
Diabetes: 68 (9)

In this Issue

September 2019, 68(9)
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by Author
  • Masthead (PDF)
Sign up to receive current issue alerts
View Selected Citations (0)
Print
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about Diabetes.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
(Your Name) has forwarded a page to you from Diabetes
(Your Name) thought you would like to see this page from the Diabetes web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
Meiyi Zhou, Jing Shao, Cheng-Yang Wu, Le Shu, Weibing Dong, Yunxia Liu, Mengping Chen, R. Max Wynn, Jiqiu Wang, Ji Wang, Wen-Jun Gui, Xiangbing Qi, Aldons J. Lusis, Zhaoping Li, Weiqing Wang, Guang Ning, Xia Yang, David T. Chuang, Yibin Wang, Haipeng Sun
Diabetes Sep 2019, 68 (9) 1730-1746; DOI: 10.2337/db18-0927

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Add to Selected Citations
Share

Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
Meiyi Zhou, Jing Shao, Cheng-Yang Wu, Le Shu, Weibing Dong, Yunxia Liu, Mengping Chen, R. Max Wynn, Jiqiu Wang, Ji Wang, Wen-Jun Gui, Xiangbing Qi, Aldons J. Lusis, Zhaoping Li, Weiqing Wang, Guang Ning, Xia Yang, David T. Chuang, Yibin Wang, Haipeng Sun
Diabetes Sep 2019, 68 (9) 1730-1746; DOI: 10.2337/db18-0927
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Research Design and Methods
    • Results
    • Discussion
    • Article Information
    • Footnotes
    • References
  • Figures & Tables
  • Suppl Material
  • Info & Metrics
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Ncor2/PPARα-Dependent Upregulation of MCUb in the Type 2 Diabetic Heart Impacts Cardiac Metabolic Flexibility and Function
  • Role of the Neutral Amino Acid Transporter SLC7A10 in Adipocyte Lipid Storage, Obesity, and Insulin Resistance
  • Heme Oxygenase-1 Regulates Ferrous Iron and Foxo1 in Control of Hepatic Gluconeogenesis
Show more Metabolism

Similar Articles

Navigate

  • Current Issue
  • Online Ahead of Print
  • Scientific Sessions Abstracts
  • Collections
  • Archives
  • Submit
  • Subscribe
  • Email Alerts
  • RSS Feeds

More Information

  • About the Journal
  • Instructions for Authors
  • Journal Policies
  • Reprints and Permissions
  • Advertising
  • Privacy Policy: ADA Journals
  • Copyright Notice/Public Access Policy
  • Contact Us

Other ADA Resources

  • Diabetes Care
  • Clinical Diabetes
  • Diabetes Spectrum
  • Scientific Sessions Abstracts
  • Standards of Medical Care in Diabetes
  • BMJ Open - Diabetes Research & Care
  • Professional Books
  • Diabetes Forecast

 

  • DiabetesJournals.org
  • Diabetes Core Update
  • ADA's DiabetesPro
  • ADA Member Directory
  • Diabetes.org

© 2021 by the American Diabetes Association. Diabetes Print ISSN: 0012-1797, Online ISSN: 1939-327X.