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Poster Presentations: Integrated Physiology/Obesity

2097-P: Weight Loss Maintenance in Medically Managed Patients with Obesity

  1. BEVERLY G. TCHANG,
  2. MOHINI ARAS,
  3. LINDSAY MANDEL,
  4. LEON I. IGEL,
  5. REKHA KUMAR,
  6. KATHERINE H. SAUNDERS,
  7. JONATHAN WAITMAN,
  8. LOUIS ARONNE and
  9. ALPANA SHUKLA
  1. New York, NY
Diabetes 2019 Jun; 68(Supplement 1): -. https://doi.org/10.2337/db19-2097-P
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Abstract

Background: The efficacy of anti-obesity medications in combination with lifestyle modification is robustly supported by randomized controlled trials, but there is a paucity of data on their effectiveness for weight loss maintenance in clinical practice.

Objectives: To investigate real-world effectiveness of anti-obesity medications (AOM) to maintain weight loss over 2 years.

Methods: A retrospective chart review of patients who established care at an academic weight management center between 4/2014-4/2016 was performed by three independent reviewers. Patients who had both 1-year and 2-year follow-up appointments were identified. Demographics, medications, and weight changes after pharmacotherapy initiation were recorded during 2-year follow-up.

Results: Of 1775 new patients, 883 met eligibility criteria, and 423 patients had weight data recorded at 1-year and 2-year time points. Patients were 74.2% female with an average age of 50.9 + 13.8 years, and 17.0% had type 2 diabetes (T2DM). The mean baseline weight and BMI were 98.6 + 22.5 kg and 35.3 + 6.87 kg/m2, respectively. The mean weight loss at year-1 and year-2 was similar (-9.9 + 7.7% vs. -10.3 + 8.8%, p=0.31). There was no statistically significant difference in weight loss between the T2DM and non-DM cohorts at 2 years (-8.69% vs. -10.48%, p=0.12). The average BMI change at 2 years was -10.7 + 9.4% (p<0.001). Seventy-five percent of patients achieved ≥ 5% weight loss at 1 year, and of these, 87.4% maintained that loss at 2 years. Forty-six percent of patients achieved ≥10% weight loss at 1 year, of which 76.9% maintained that loss at 2 years. At 2 years, 96.2% of patients remained on > 1 weight loss medication with an average of 2.4 + 1.2 drugs. The most commonly prescribed weight-loss pharmacotherapies were metformin (71.5%), phentermine (23.3%) and topiramate (19.9%).

Conclusions: Clinically significant weight loss maintenance over 2 years is achievable with the use of multi-drug weight-loss pharmacotherapy in a specialty care center.

Disclosure B.G. Tchang: None. M. Aras: None. L. Mandel: None. L.I. Igel: None. R. Kumar: Speaker's Bureau; Self; Janssen Pharmaceuticals, Inc., Novo Nordisk Inc. Stock/Shareholder; Self; VIVUS, Inc., Zafgen, Inc. K.H. Saunders: None. J. Waitman: None. L. Aronne: Advisory Panel; Self; Eisai Inc., Gelesis, Jamieson Wellness Inc., Janssen Pharmaceuticals, Inc., Novo Nordisk Inc., Pfizer Inc., Real Appeal, Inc., UnitedHealth Group Inc. Board Member; Self; BMIQ Professionals Program, Jamieson Wellness Inc., MYOS Corp. Consultant; Self; Eisai Inc., Gelesis, Jamieson Wellness Inc., Janssen Pharmaceuticals, Inc., Novo Nordisk Inc., Real Appeal, Inc., UnitedHealth Group Inc. Research Support; Self; Allurion, Aspire Bariatrics, AstraZeneca, Eisai Inc., Janssen Pharmaceuticals, Inc., Novo Nordisk Inc. Stock/Shareholder; Self; BMIQ Professionals Program, ERX Pharmaceuticals, Inc., Gelesis, Jamieson Wellness Inc., MYOS Corp, Zafgen, Inc. A. Shukla: None.

  • © 2019 by the American Diabetes Association.
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2097-P: Weight Loss Maintenance in Medically Managed Patients with Obesity
BEVERLY G. TCHANG, MOHINI ARAS, LINDSAY MANDEL, LEON I. IGEL, REKHA KUMAR, KATHERINE H. SAUNDERS, JONATHAN WAITMAN, LOUIS ARONNE, ALPANA SHUKLA
Diabetes Jun 2019, 68 (Supplement 1) 2097-P; DOI: 10.2337/db19-2097-P

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2097-P: Weight Loss Maintenance in Medically Managed Patients with Obesity
BEVERLY G. TCHANG, MOHINI ARAS, LINDSAY MANDEL, LEON I. IGEL, REKHA KUMAR, KATHERINE H. SAUNDERS, JONATHAN WAITMAN, LOUIS ARONNE, ALPANA SHUKLA
Diabetes Jun 2019, 68 (Supplement 1) 2097-P; DOI: 10.2337/db19-2097-P
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