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Diabetes Symposium

Subtypes of Type 2 Diabetes Determined From Clinical Parameters

  1. Emma Ahlqvist1⇑,
  2. Rashmi B. Prasad1 and
  3. Leif Groop1,2
  1. 1Department of Clinical Sciences, Genomics, Diabetes and Endocrinology, Lund University Diabetes Centre, Lund University, Malmö, Sweden
  2. 2Finnish Institute of Molecular Medicine Finland (FIMM), Helsinki University, Helsinki, Finland
  1. Corresponding author: Emma Ahlqvist, emma.ahlqvist{at}med.lu.se
Diabetes 2020 Oct; 69(10): 2086-2093. https://doi.org/10.2337/dbi20-0001
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    Figure 1

    Schematic representations of diabetes classification and models of heterogeneity. A: The traditional classification of diabetes where T1D and T2D are viewed as distinct subgroups but with an overlap including intermediate diabetes types such as LADA. Monogenic and secondary diabetes are rare, etiologically distinct subtypes that are not included in the novel subclassification. B: The palette model where the many molecular pathways involved in diabetes pathogenesis are represented as colors and each individual with T2D is represented by the mixed colors of all the pathways affected in that individual. C: The ANDIS model, where colors instead represent clinical parameters, reflecting the underlying mechanisms, that are easy to measure in the clinic. With this approach, individuals are grouped based on their main color into subtypes with different clinical characteristics.

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    Figure 2

    Novel diabetes subtype characteristics. Overview of distribution and characteristics of subtypes generated by clustering based on clinical parameters in the Swedish ANDIS cohort.

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    Figure 3

    Adjusted risk of diabetic kidney complications. Cumulative incidence of CKD stage 3A in ANDIS (HRSIRDvsMARD = 1.39, P = 0.018) (A) and ESRD in SDR (HRSIRDvsMARD = 2.53, P = 0.047) (B) in individuals with eGFR >60 at the first measurement after diagnosis, adjusted for sex, age, BMI, HbA1c, and first eGFR. HR, hazard ratio.

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Diabetes: 69 (10)

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October 2020, 69(10)
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Subtypes of Type 2 Diabetes Determined From Clinical Parameters
Emma Ahlqvist, Rashmi B. Prasad, Leif Groop
Diabetes Oct 2020, 69 (10) 2086-2093; DOI: 10.2337/dbi20-0001

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Subtypes of Type 2 Diabetes Determined From Clinical Parameters
Emma Ahlqvist, Rashmi B. Prasad, Leif Groop
Diabetes Oct 2020, 69 (10) 2086-2093; DOI: 10.2337/dbi20-0001
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