Obesity Studies

Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis

  1. Chiara Ruocco1,
  2. Maurizio Ragni1,
  3. Fabio Rossi1,
  4. Pierluigi Carullo2,3,
  5. Veronica Ghini4,
  6. Fabiana Piscitelli5,
  7. Adele Cutignano5,
  8. Emiliano Manzo5,
  9. Rafael Maciel Ioris6,7,
  10. Franck Bontems6,7,
  11. Laura Tedesco1,
  12. Carolina M. Greco2,
  13. Annachiara Pino8,
  14. Ilenia Severi9,
  15. Dianxin Liu10,
  16. Ryan P. Ceddia10,
  17. Luisa Ponzoni1,11,
  18. Leonardo Tenori12,13,
  19. Lisa Rizzetto14,
  20. Matthias Scholz14,
  21. Kieran Tuohy14,
  22. Francesco Bifari15,
  23. Vincenzo Di Marzo16,17,
  24. Claudio Luchinat4,18,
  25. Michele O. Carruba1,
  26. Saverio Cinti9,
  27. Ilaria Decimo8,
  28. Gianluigi Condorelli2,3,19,
  29. Roberto Coppari6,7,
  30. Sheila Collins10,
  31. Alessandra Valerio20 and
  32. Enzo Nisoli1⇑
  1. 1Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy
  2. 2IRCCS Humanitas Clinical and Research Center, Rozzano, Italy
  3. 3Institute of Genetic and Biomedical Research, National Research Council, Rozzano, Italy
  4. 4Interuniversity Consortium for Magnetic Resonance, Sesto Fiorentino, Italy
  5. 5Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy
  6. 6Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
  7. 7Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland
  8. 8Department of Diagnostics and Public Health, University of Verona, Verona, Italy
  9. 9Department of Experimental and Clinical Medicine, Marche Polytechnic University, Center of Obesity, Ancona, Italy
  10. 10Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
  11. 11Institute of Neuroscience, National Research Council, Milan, Italy
  12. 12FiorGen Foundation, Sesto Fiorentino, Italy
  13. 13Center of Magnetic Resonance, University of Florence, Sesto Fiorentino, Italy
  14. 14Department of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all’Adige, Italy
  15. 15Laboratory of Cell Metabolism and Regenerative Medicine, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
  16. 16Canada Excellence Research Chair Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval, Quebec City, Canada
  17. 17Joint International Research Unit for Chemical and Biochemical Research on the Microbiome and Its Impact on Metabolic Health and Nutrition, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy and Université Laval, Quebec City, Canada
  18. 18Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
  19. 19Humanitas University, Rozzano, Italy
  20. 20Department of Molecular and Translational Medicine, Brescia University, Brescia, Italy
  1. Corresponding author: Enzo Nisoli, enzo.nisoli{at}unimi.it

  1. C.R. and M.R. contributed equally to this work.

Diabetes 2020 Nov; 69(11): 2324-2339. https://doi.org/10.2337/db20-0489

Data supplements

  • Supplemental material, Nisoli, et al.

    Supplemental material is available at https://doi.org/10.2337/figshare.12771341.
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    Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
    Chiara Ruocco, Maurizio Ragni, Fabio Rossi, Pierluigi Carullo, Veronica Ghini, Fabiana Piscitelli, Adele Cutignano, Emiliano Manzo, Rafael Maciel Ioris, Franck Bontems, Laura Tedesco, Carolina M. Greco, Annachiara Pino, Ilenia Severi, Dianxin Liu, Ryan P. Ceddia, Luisa Ponzoni, Leonardo Tenori, Lisa Rizzetto, Matthias Scholz, Kieran Tuohy, Francesco Bifari, Vincenzo Di Marzo, Claudio Luchinat, Michele O. Carruba, Saverio Cinti, Ilaria Decimo, Gianluigi Condorelli, Roberto Coppari, Sheila Collins, Alessandra Valerio, Enzo Nisoli
    Diabetes Nov 2020, 69 (11) 2324-2339; DOI: 10.2337/db20-0489
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