Obesity Studies
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
- Chiara Ruocco1,
- Maurizio Ragni1,
- Fabio Rossi1,
- Pierluigi Carullo2,3,
- Veronica Ghini4,
- Fabiana Piscitelli5,
- Adele Cutignano5,
- Emiliano Manzo5,
- Rafael Maciel Ioris6,7,
- Franck Bontems6,7,
- Laura Tedesco1,
- Carolina M. Greco2,
- Annachiara Pino8,
- Ilenia Severi9,
- Dianxin Liu10,
- Ryan P. Ceddia10,
- Luisa Ponzoni1,11,
- Leonardo Tenori12,13,
- Lisa Rizzetto14,
- Matthias Scholz14,
- Kieran Tuohy14,
- Francesco Bifari15,
- Vincenzo Di Marzo16,17,
- Claudio Luchinat4,18,
- Michele O. Carruba1,
- Saverio Cinti9,
- Ilaria Decimo8,
- Gianluigi Condorelli2,3,19,
- Roberto Coppari6,7,
- Sheila Collins10,
- Alessandra Valerio20 and
- Enzo Nisoli1⇑
- 1Center for Study and Research on Obesity, Department of Biomedical Technology and Translational Medicine, University of Milan, Milan, Italy
- 2IRCCS Humanitas Clinical and Research Center, Rozzano, Italy
- 3Institute of Genetic and Biomedical Research, National Research Council, Rozzano, Italy
- 4Interuniversity Consortium for Magnetic Resonance, Sesto Fiorentino, Italy
- 5Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy
- 6Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
- 7Diabetes Center of the Faculty of Medicine, University of Geneva, Geneva, Switzerland
- 8Department of Diagnostics and Public Health, University of Verona, Verona, Italy
- 9Department of Experimental and Clinical Medicine, Marche Polytechnic University, Center of Obesity, Ancona, Italy
- 10Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
- 11Institute of Neuroscience, National Research Council, Milan, Italy
- 12FiorGen Foundation, Sesto Fiorentino, Italy
- 13Center of Magnetic Resonance, University of Florence, Sesto Fiorentino, Italy
- 14Department of Food Quality and Nutrition, Research and Innovation Center, Edmund Mach Foundation, San Michele all’Adige, Italy
- 15Laboratory of Cell Metabolism and Regenerative Medicine, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy
- 16Canada Excellence Research Chair Microbiome-Endocannabinoidome Axis in Metabolic Health, Université Laval, Quebec City, Canada
- 17Joint International Research Unit for Chemical and Biochemical Research on the Microbiome and Its Impact on Metabolic Health and Nutrition, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy and Université Laval, Quebec City, Canada
- 18Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
- 19Humanitas University, Rozzano, Italy
- 20Department of Molecular and Translational Medicine, Brescia University, Brescia, Italy
- Corresponding author: Enzo Nisoli, enzo.nisoli{at}unimi.it
C.R. and M.R. contributed equally to this work.

Data supplements
Supplemental material, Nisoli, et al.
Supplemental material is available at https://doi.org/10.2337/figshare.12771341.
In this Issue
November 2020, 69(11)
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
Chiara Ruocco, Maurizio Ragni, Fabio Rossi, Pierluigi Carullo, Veronica Ghini, Fabiana Piscitelli, Adele Cutignano, Emiliano Manzo, Rafael Maciel Ioris, Franck Bontems, Laura Tedesco, Carolina M. Greco, Annachiara Pino, Ilenia Severi, Dianxin Liu, Ryan P. Ceddia, Luisa Ponzoni, Leonardo Tenori, Lisa Rizzetto, Matthias Scholz, Kieran Tuohy, Francesco Bifari, Vincenzo Di Marzo, Claudio Luchinat, Michele O. Carruba, Saverio Cinti, Ilaria Decimo, Gianluigi Condorelli, Roberto Coppari, Sheila Collins, Alessandra Valerio, Enzo Nisoli
Diabetes Nov 2020, 69 (11) 2324-2339; DOI: 10.2337/db20-0489
Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis
Chiara Ruocco, Maurizio Ragni, Fabio Rossi, Pierluigi Carullo, Veronica Ghini, Fabiana Piscitelli, Adele Cutignano, Emiliano Manzo, Rafael Maciel Ioris, Franck Bontems, Laura Tedesco, Carolina M. Greco, Annachiara Pino, Ilenia Severi, Dianxin Liu, Ryan P. Ceddia, Luisa Ponzoni, Leonardo Tenori, Lisa Rizzetto, Matthias Scholz, Kieran Tuohy, Francesco Bifari, Vincenzo Di Marzo, Claudio Luchinat, Michele O. Carruba, Saverio Cinti, Ilaria Decimo, Gianluigi Condorelli, Roberto Coppari, Sheila Collins, Alessandra Valerio, Enzo Nisoli
Diabetes Nov 2020, 69 (11) 2324-2339; DOI: 10.2337/db20-0489