Diabetes: 69 (2)

February 01 2020; volume 69 issue 2

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Open Access
In This Issue of Diabetes
Diabetes 2020 Feb; 69 (2): 129-130. https://doi.org/10.2337/db20-ti02

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Metabolism

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Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels
Evan P. Taddeo, Nour Alsabeeh, Siyouneh Baghdasarian, Jakob D. Wikstrom, Eleni Ritou, Samuel Sereda, Karel Erion, Jin Li, Linsey Stiles, Muhamad Abdulla, Zachary Swanson, Joshua J. Wilhelm, Melena D. Bellin, Richard G. Kibbey, Marc Liesa and Orian S. Shirihai

Diabetes 2020 Feb; 69 (2): 131-145. https://doi.org/10.2337/db19-0379

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Effects of Pioglitazone on Glucose-Dependent Insulinotropic Polypeptide–Mediated Insulin Secretion and Adipocyte Receptor Expression in Patients With Type 2 Diabetes
William G. Tharp, Dhananjay Gupta, Olga Sideleva, Carolyn F. Deacon, Jens J. Holst, Dariush Elahi and Richard E. Pratley

Diabetes 2020 Feb; 69 (2): 146-157. https://doi.org/10.2337/db18-1163

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Obesity Studies

Open Access
Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice
Akihito Takei, Shuichi Nagashima, Shoko Takei, Daisuke Yamamuro, Akiko Murakami, Tetsuji Wakabayashi, Masayo Isoda, Hisataka Yamazaki, Chihiro Ebihara, Manabu Takahashi, Ken Ebihara and Shun Ishibashi

Diabetes 2020 Feb; 69 (2): 158-164. https://doi.org/10.2337/db19-0076

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Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue
Peng Gao, Yanli Jiang, Hao Wu, Fang Sun, Yaohong Li, Hongbo He, Bin Wang, Zongshi Lu, Yingru Hu, Xiao Wei, Yuanting Cui, Chengkang He, Lijuan Wang, Hongting Zheng, Gangyi Yang, Daoyan Liu, Zhencheng Yan and Zhiming Zhu

Diabetes 2020 Feb; 69 (2): 165-180. https://doi.org/10.2337/db19-0526

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Impaired Metabolic Flexibility to High-Fat Overfeeding Predicts Future Weight Gain in Healthy Adults
Brittany Begaye, Karyne L. Vinales, Tim Hollstein, Takafumi Ando, Mary Walter, Clifton Bogardus, Jonathan Krakoff and Paolo Piaggi

Diabetes 2020 Feb; 69 (2): 181-192. https://doi.org/10.2337/db19-0719

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Islet Studies

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Tacrolimus-Induced BMP/SMAD Signaling Associates With Metabolic Stress–Activated FOXO1 to Trigger β-Cell Failure
Javier Triñanes, Peter ten Dijke, Nathalie Groen, Maaike Hanegraaf, Esteban Porrini, Ana E. Rodriguez-Rodriguez, Cinthia Drachenberg, Ton J. Rabelink, Eelco de Koning, Françoise Carlotti and Aiko P.J. de Vries

Diabetes 2020 Feb; 69 (2): 193-204. https://doi.org/10.2337/db19-0828

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Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation
Joon Ho Moon, Yeong Gi Kim, Kyuho Kim, Sho Osonoi, Shuang Wang, Diane C. Saunders, Juehu Wang, Katherine Yang, Hyeongseok Kim, Junguee Lee, Ji-Seon Jeong, Ronadip R. Banerjee, Seung K. Kim, Yingjie Wu, Hiroki Mizukami, Alvin C. Powers, Michael S. German and Hail Kim

Diabetes 2020 Feb; 69 (2): 205-214. https://doi.org/10.2337/db19-0546

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Immunology and Transplantation

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Immunomodulation Followed by Antigen-Specific T_reg Infusion Controls Islet Autoimmunity
Cecilia Cabello-Kindelan, Shane Mackey, Alexander Sands, Jennifer Rodriguez, Claudia Vazquez, Alberto Pugliese and Allison L. Bayer

Diabetes 2020 Feb; 69 (2): 215-227. https://doi.org/10.2337/db19-0061

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Complications

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Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia
Kripa Shankar, Deepali Gupta, Bharath K. Mani, Brianna G. Findley, Caleb C. Lord, Sherri Osborne-Lawrence, Nathan P. Metzger, Claudio Pietra, Chen Liu, Eric D. Berglund and Jeffrey M. Zigman

Diabetes 2020 Feb; 69 (2): 228-237. https://doi.org/10.2337/db19-0438

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Genetics/Genomes/Proteomics/Metabolomics

Open Access
Predictive Modeling of Type 1 Diabetes Stages Using Disparate Data Sources
Brigitte I. Frohnert, Bobbie-Jo Webb-Robertson, Lisa M. Bramer, Sara M. Reehl, Kathy Waugh, Andrea K. Steck, Jill M. Norris and Marian Rewers

Diabetes 2020 Feb; 69 (2): 238-248. https://doi.org/10.2337/db18-1263

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Open Access
Clinical and Molecular Prevalence of Lipodystrophy in an Unascertained Large Clinical Care Cohort
Claudia Gonzaga-Jauregui, Wenzhen Ge, Jeffrey Staples, Cristopher Van Hout, Ashish Yadav, Ryan Colonie, Joseph B. Leader, H. Lester Kirchner, Michael F. Murray, Jeffrey G. Reid, David J. Carey, John D. Overton, Alan R. Shuldiner, Omri Gottesman, Steve Gao, Jesper Gromada, Aris Baras and Judith Altarejos, on behalf of the Geisinger-Regeneron DiscovEHR collaboration

Diabetes 2020 Feb; 69 (2): 249-258. https://doi.org/10.2337/db19-0447

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Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank
Hassan S. Dashti, Céline Vetter, Jacqueline M. Lane, Matt C. Smith, Andrew R. Wood, Michael N. Weedon, Martin K. Rutter, Marta Garaulet, Frank A.J.L. Scheer and Richa Saxena

Diabetes 2020 Feb; 69 (2): 259-266. https://doi.org/10.2337/db19-0606

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Errata

Open Access
Erratum. Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts. Diabetes 2018;67:
Junlian Gu, Xiaoqing Yan, Xiaozhen Dai, Yuehui Wang, Qian Lin, Jian Xiao, Shanshan Zhou, Jian Zhang, Kai Wang, Jun Zeng, Ying Xin, Michelle T. Barati, Chi Zhang, Yang Bai, Yan Li, Paul N. Epstein, Kupper A. Wintergerst, Xiaokun Li, Yi Tan and Lu Cai

Diabetes 2020 Feb; 69 (2): 267. https://doi.org/10.2337/db20-er02a

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Open Access
Erratum. Overexpression of Circulating Soluble Nogo-B Improves Diabetic Kidney Disease by Protecting the Vasculature. Diabetes 2019;68:
Ivan Hernandez-Diaz, Jiaqi Pan, Carlo Alberto Ricciardi, Xiaoyan Bai, Jianting Ke, Kathryn E. White, Maria Flaquer, Georgia E. Fouli, Fulye Argunhan, Anthea E. Hayward, Fan Fan Hou, Giovanni E. Mann, Robert Q. Miao, David A. Long and Luigi Gnudi

Diabetes 2020 Feb; 69 (2): 267. https://doi.org/10.2337/db20-er02b

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Open Access
Erratum. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes 2019;68:
Yanqing Zhang, Keshab R. Parajuli, Genevieve E. Fava, Rajesh Gupta, Weiwei Xu, Lauren U. Nguyen, Anadil F. Zakaria, Vivian A. Fonseca, Hongjun Wang, Franck Mauvais-Jarvis, Kyle W. Sloop and Hongju Wu

Diabetes 2020 Feb; 69 (2): 267-268. https://doi.org/10.2337/db20-er02c

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Issues and Events

Open Access
Issues and Events
Diabetes 2020 Feb; 69 (2): 269. https://doi.org/10.2337/db20-ie02

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e-Letters

Comments and Responses
- Open Access
  Comment on Liu et al. Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 2017;66:689–698
  Siauyen Wong, Rick F. Nelson, Peiran Lu, Henry Paulson and Dingbo Lin
  
  Diabetes 2020 Feb; 69 (2): e1. https://doi.org/10.2337/db19-0975
  
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- Open Access
  Response to Comment on Liu et al. Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice. Diabetes 2017;66:689–698
  Bin Liu and Yan Lu
  
  Diabetes 2020 Feb; 69 (2): e2. https://doi.org/10.2337/dbi19-0028
  
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Table of Contents

In This Issue

Metabolism

Obesity Studies

Islet Studies

Immunology and Transplantation

Complications

Genetics/Genomes/Proteomics/Metabolomics

Errata

Issues and Events

e-Letters

Comments and Responses

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