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Signal Transduction

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling

  1. Mari Lilith Lund1,
  2. Giovanni Sorrentino2,
  3. Kristoffer Lihme Egerod1,
  4. Chantal Kroone3,
  5. Brynjulf Mortensen4,
  6. Filip Krag Knop1,4,5,6,
  7. Frank Reimann7,
  8. Fiona M. Gribble7,
  9. Daniel J. Drucker8,
  10. Eelco J.P. de Koning9,10,
  11. Kristina Schoonjans2,
  12. Fredrik Bäckhed1,11,
  13. Thue W. Schwartz1,12 and
  14. Natalia Petersen1⇑
  1. 1Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  2. 2Laboratory of Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
  3. 3Department of Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, the Netherlands
  4. 4Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
  5. 5Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  6. 6Steno Diabetes Center Copenhagen, Gentofte, Denmark
  7. 7Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, U.K.
  8. 8Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
  9. 9Department of Medicine, Leiden University Medical Centre, Leiden, the Netherlands
  10. 10Hubrecht Institute/Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
  11. 11Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  12. 12Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  1. Corresponding author: Natalia Petersen, napt{at}novonordisk.com
Diabetes 2020 Apr; 69(4): 614-623. https://doi.org/10.2337/db19-0764
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Article Information

vol. 69 no. 4 614-623
DOI 
https://doi.org/10.2337/db19-0764
PubMed 
32041793

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received August 5, 2019
  • Accepted January 22, 2020
  • Published in print March 20, 2020.
  • Published online ahead of print February 10, 2020.

Article Versions

  • Previous version (February 10, 2020 - 14:18).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2020 by the American Diabetes Association. https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

Author Information

  1. Mari Lilith Lund1,
  2. Giovanni Sorrentino2,
  3. Kristoffer Lihme Egerod1,
  4. Chantal Kroone3,
  5. Brynjulf Mortensen4,
  6. Filip Krag Knop1,4,5,6,
  7. Frank Reimann7,
  8. Fiona M. Gribble7,
  9. Daniel J. Drucker8,
  10. Eelco J.P. de Koning9,10,
  11. Kristina Schoonjans2,
  12. Fredrik Bäckhed1,11,
  13. Thue W. Schwartz1,12 and
  14. Natalia Petersen1⇑
  1. 1Novo Nordisk Foundation Center for Basic Metabolic Research Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  2. 2Laboratory of Metabolic Signaling, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
  3. 3Department of Thrombosis and Hemostasis, Leiden University Medical Centre, Leiden, the Netherlands
  4. 4Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark
  5. 5Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  6. 6Steno Diabetes Center Copenhagen, Gentofte, Denmark
  7. 7Institute of Metabolic Science and Medical Research Council Metabolic Diseases Unit, University of Cambridge, Addenbrooke’s Hospital, Cambridge, U.K.
  8. 8Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
  9. 9Department of Medicine, Leiden University Medical Centre, Leiden, the Netherlands
  10. 10Hubrecht Institute/Koninklijke Nederlandse Akademie van Wetenschappen (KNAW) and University Medical Center Utrecht, Utrecht, the Netherlands
  11. 11Department of Molecular and Clinical Medicine at Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  12. 12Laboratory for Molecular Pharmacology, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
  1. Corresponding author: Natalia Petersen, napt{at}novonordisk.com
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L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M. Gribble, Daniel J. Drucker, Eelco J.P. de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W. Schwartz, Natalia Petersen
Diabetes Apr 2020, 69 (4) 614-623; DOI: 10.2337/db19-0764

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L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Mari Lilith Lund, Giovanni Sorrentino, Kristoffer Lihme Egerod, Chantal Kroone, Brynjulf Mortensen, Filip Krag Knop, Frank Reimann, Fiona M. Gribble, Daniel J. Drucker, Eelco J.P. de Koning, Kristina Schoonjans, Fredrik Bäckhed, Thue W. Schwartz, Natalia Petersen
Diabetes Apr 2020, 69 (4) 614-623; DOI: 10.2337/db19-0764
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