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Table of Contents

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August 01 2020; volume 69 issue 8

Perspectives in Diabetes

  • Open Access
    The Heating Microenvironment: Intercellular Cross Talk Within Thermogenic Adipose Tissue
    Alexander J. Knights, Jun Wu and Yu-Hua Tseng
    Diabetes 2020 Aug; 69 (8): 1599-1604. https://doi.org/10.2337/db20-0303
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Commentaries

  • Open Access
    A New FGF21 Analog for the Treatment of Fatty Liver Disease
    Maximilian Kleinert and Timo D. Müller
    Diabetes 2020 Aug; 69 (8): 1605-1607. https://doi.org/10.2337/dbi20-0025
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  • Open Access
    Smarter Modeling to Enable a Smarter Insulin
    Simeon I. Taylor and Richard D. DiMarchi
    Diabetes 2020 Aug; 69 (8): 1608-1610. https://doi.org/10.2337/dbi20-0011
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Metabolism

  • You have accessRestricted Access
    The Effects of B1344, a Novel Fibroblast Growth Factor 21 Analog, on Nonalcoholic Steatohepatitis in Nonhuman Primates
    Aoyuan Cui, Jian Li, Shaohui Ji, Fengguang Ma, Genbei Wang, Yaqian Xue, Zhengshuai Liu, Jing Gao, Jun Han, Ping Tai, Tony Wang, Jianxun Chen, Xiaohui Ma and Yu Li
    Diabetes 2020 Aug; 69 (8): 1611-1623. https://doi.org/10.2337/db20-0209
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    Lactation Versus Formula Feeding: Insulin, Glucose, and Fatty Acid Metabolism During the Postpartum Period
    Maria A. Ramos-Roman, Majid M. Syed-Abdul, Beverley Adams-Huet, Brian M. Casey and Elizabeth J. Parks
    Diabetes 2020 Aug; 69 (8): 1624-1635. https://doi.org/10.2337/db19-1226
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    Reciprocity Between Skeletal Muscle AMPK Deletion and Insulin Action in Diet-Induced Obese Mice
    Louise Lantier, Ashley S. Williams, Ian M. Williams, Amanda Guerin, Deanna P. Bracy, Mickael Goelzer, Marc Foretz, Benoit Viollet, Curtis C. Hughey and David H. Wasserman
    Diabetes 2020 Aug; 69 (8): 1636-1649. https://doi.org/10.2337/db19-1074
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    Antioxidant Effects of N-Acetylcysteine Prevent Programmed Metabolic Disease in Mice
    Maureen J. Charron, Lyda Williams, Yoshinori Seki, Xiu Quan Du, Bhagirath Chaurasia, Alan Saghatelian, Scott A. Summers, Ellen B. Katz, Patricia M. Vuguin and Sandra E. Reznik
    Diabetes 2020 Aug; 69 (8): 1650-1661. https://doi.org/10.2337/db19-1129
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Obesity Studies

  • Open Access
    Excessive Glucocorticoids During Pregnancy Impair Fetal Brown Fat Development and Predispose Offspring to Metabolic Dysfunctions
    Yan-Ting Chen, Yun Hu, Qi-Yuan Yang, Jun Seok Son, Xiang-Dong Liu, Jeanene M. de Avila, Mei-Jun Zhu and Min Du
    Diabetes 2020 Aug; 69 (8): 1662-1674. https://doi.org/10.2337/db20-0009
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  • You have accessRestricted Access
    Exercise-Induced Increases in Insulin Sensitivity After Bariatric Surgery Are Mediated By Muscle Extracellular Matrix Remodeling
    Wagner S. Dantas, Hamilton Roschel, Igor H. Murai, Saulo Gil, Gangarao Davuluri, Christopher L. Axelrod, Sujoy Ghosh, Susan S. Newman, Hui Zhang, Samuel K. Shinjo, Willian das Neves, Carlos Merege-Filho, Walcy R. Teodoro, Vera L. Capelozzi, Rosa Maria Pereira, Fabiana B. Benatti, Ana L. de Sá-Pinto, Roberto de Cleva, Marco A. Santo, John P. Kirwan and Bruno Gualano
    Diabetes 2020 Aug; 69 (8): 1675-1691. https://doi.org/10.2337/db19-1180
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Islet Studies

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    Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes
    Geming Lu, Francisco Rausell-Palamos, Jiamin Zhang, Zihan Zheng, Tuo Zhang, Shelley Valle, Carolina Rosselot, Cecilia Berrouet, Patricia Conde, Matthew P. Spindler, John G. Graham, Dirk Homann and Adolfo Garcia-Ocaña
    Diabetes 2020 Aug; 69 (8): 1692-1707. https://doi.org/10.2337/db19-0725
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    m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells
    Yanqiu Wang, Jiajun Sun, Zhen Lin, Weizhen Zhang, Shu Wang, Weiqing Wang, Qidi Wang and Guang Ning
    Diabetes 2020 Aug; 69 (8): 1708-1722. https://doi.org/10.2337/db19-0906
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    Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding
    Duc T. Tran, Anita Pottekat, Saiful A. Mir, Salvatore Loguercio, Insook Jang, Alexandre Rosa Campos, Kathleen M. Scully, Reyhaneh Lahmy, Ming Liu, Peter Arvan, William E. Balch, Randal J. Kaufman and Pamela Itkin-Ansari
    Diabetes 2020 Aug; 69 (8): 1723-1734. https://doi.org/10.2337/db20-0245
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Immunology and Transplantation

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    Low-Dose Interleukin-2 Combined With Rapamycin Led to an Expansion of CD4+CD25+FOXP3+ Regulatory T Cells and Prolonged Human Islet Allograft Survival in Humanized Mice
    Min Hu, Wayne J. Hawthorne, Leigh Nicholson, Heather Burns, Yi Wen Qian, David Liuwantara, Elvira Jimenez Vera, Yi Vee Chew, Lindy Williams, Shounan Yi, Karen Keung, Debbie Watson, Natasha Rogers, Stephen I. Alexander and Philip J. O’Connell
    Diabetes 2020 Aug; 69 (8): 1735-1748. https://doi.org/10.2337/db19-0525
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    NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8+ T-Cell Numbers
    Andrew P. Trembath, Kelsey L. Krausz, Neekun Sharma, Ivan C. Gerling, Clayton E. Mathews and Mary A. Markiewicz
    Diabetes 2020 Aug; 69 (8): 1749-1762. https://doi.org/10.2337/db19-0979
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  • Open Access
    Failed Genetic Protection: Type 1 Diabetes in the Presence of HLA-DQB1*06:02
    Kimber M. Simmons, Angela M. Mitchell, Aimon A. Alkanani, Kristen A. McDaniel, Erin E. Baschal, Taylor Armstrong, Laura Pyle, Liping Yu and Aaron W. Michels
    Diabetes 2020 Aug; 69 (8): 1763-1769. https://doi.org/10.2337/db20-0038
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Pathophysiology

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    Brain Function Differences in Children With Type 1 Diabetes: A Functional MRI Study of Working Memory
    Lara C. Foland-Ross, Gabby Tong, Nelly Mauras, Allison Cato, Tandy Aye, Michael Tansey, Neil H. White, Stuart A. Weinzimer, Kimberly Englert, Hanyang Shen, Paul K. Mazaika and Allan L. Reiss, for the Diabetes Research in Children Network (DirecNet)
    Diabetes 2020 Aug; 69 (8): 1770-1778. https://doi.org/10.2337/db20-0123
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Complications

  • You have accessRestricted Access
    Endothelial Overexpression of Metallothionein Prevents Diabetes-Induced Impairment in Ischemia Angiogenesis Through Preservation of HIF-1α/SDF-1/VEGF Signaling in Endothelial Progenitor Cells
    Kai Wang, Xiaozhen Dai, Junhong He, Xiaoqing Yan, Chengkui Yang, Xia Fan, Shiyue Sun, Jing Chen, Jianxiang Xu, Zhongbin Deng, Jiawei Fan, Xiaohuan Yuan, Hairong Liu, Edward C. Carlson, Feixia Shen, Kupper A. Wintergerst, Daniel J. Conklin, Paul N. Epstein, Chaosheng Lu and Yi Tan
    Diabetes 2020 Aug; 69 (8): 1779-1792. https://doi.org/10.2337/db19-0829
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  • Open Access
    PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment
    Longhua Liu, Lihong Fan, Michelle Chan, Michael J. Kraakman, Jing Yang, Yong Fan, Nicole Aaron, Qianfen Wan, Maria Alicia Carrillo-Sepulveda, Alan R. Tall, Ira Tabas, Domenico Accili and Li Qiang
    Diabetes 2020 Aug; 69 (8): 1793-1803. https://doi.org/10.2337/db20-0217
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    Determinants of Treatment Response in Painful Diabetic Peripheral Neuropathy: A Combined Deep Sensory Phenotyping and Multimodal Brain MRI Study
    Iain David Wilkinson, Kevin Teh, Francesa Heiberg-Gibbons, Mohammad Awadh, Alan Kelsall, Pallai Shillo, Gordon Sloan, Solomon Tesfaye and Dinesh Selvarajah
    Diabetes 2020 Aug; 69 (8): 1804-1814. https://doi.org/10.2337/db20-0029
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Pharmacology and Therapeutics

  • You have accessRestricted Access
    Connecting Rodent and Human Pharmacokinetic Models for the Design and Translation of Glucose-Responsive Insulin
    Jing Fan Yang, Xun Gong, Naveed A. Bakh, Kelley Carr, Nelson F.B. Phillips, Faramarz Ismail-Beigi, Michael A. Weiss and Michael S. Strano
    Diabetes 2020 Aug; 69 (8): 1815-1826. https://doi.org/10.2337/db19-0879
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  • Open Access
    Slowed Metabolic Decline After 1 Year of Oral Insulin Treatment Among Individuals at High Risk for Type 1 Diabetes in the Diabetes Prevention Trial–Type 1 (DPT-1) and TrialNet Oral Insulin Prevention Trials
    Jay M. Sosenko, Jay S. Skyler, Kevan C. Herold, Desmond A. Schatz, Michael J. Haller, Alberto Pugliese, Mario Cleves, Susan Geyer, Lisa E. Rafkin, Della Matheson and Jerry P. Palmer, for the Type 1 Diabetes TrialNet Study Group
    Diabetes 2020 Aug; 69 (8): 1827-1832. https://doi.org/10.2337/db20-0166
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Genetics/Genomes/Proteomics/Metabolomics

  • Open Access
    Longitudinal Analysis of Serum Cytokine Levels and Gut Microbial Abundance Links IL-17/IL-22 With Clostridia and Insulin Sensitivity in Humans
    Xin Zhou, Jethro S. Johnson, Daniel Spakowicz, Wenyu Zhou, Yanjiao Zhou, Erica Sodergren, Michael Snyder and George M. Weinstock
    Diabetes 2020 Aug; 69 (8): 1833-1842. https://doi.org/10.2337/db19-0592
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  • Open Access
    Circulating Protein Signatures and Causal Candidates for Type 2 Diabetes
    Valborg Gudmundsdottir, Shaza B. Zaghlool, Valur Emilsson, Thor Aspelund, Marjan Ilkov, Elias F. Gudmundsson, Stefan M. Jonsson, Nuno R. Zilhão, John R. Lamb, Karsten Suhre, Lori L. Jennings and Vilmundur Gudnason
    Diabetes 2020 Aug; 69 (8): 1843-1853. https://doi.org/10.2337/db19-1070
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Errata

  • Open Access
    Erratum. TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet–Induced Insulin Resistance in Skeletal Muscle. Diabetes 2019;68:1552–1564
    Jin-Ho Koh, Matthew L. Johnson, Surendra Dasari, Nathan K. LeBrasseur, Ivan Vuckovic, Gregory C. Henderson, Shawna A. Cooper, Shankarappa Manjunatha, Gregory N. Ruegsegger, Gerald I. Shulman, Ian R. Lanza and K. Sreekumaran Nair
    Diabetes 2020 Aug; 69 (8): 1854. https://doi.org/10.2337/db20-er08a
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  • Open Access
    Erratum. Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2. Diabetes 2019;68:2287–2300
    Barend W. Florijn, Jacques M.G.J. Duijs, Johannes H. Levels, Geesje M. Dallinga-Thie, Yanan Wang, Anita N. Boing, Yuana Yuana, Wendy Stam, Ronald W.A.L. Limpens, Yu Wah Au, Rienk Nieuwland, Ton J. Rabelink, Marlies E.J. Reinders, Anton Jan van Zonneveld and Roel Bijkerk
    Diabetes 2020 Aug; 69 (8): 1855. https://doi.org/10.2337/db20-er08b
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Issues and Events

  • Open Access
    Issues and Events
    Diabetes 2020 Aug; 69 (8): 1856. https://doi.org/10.2337/db20-ie08
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Diabetes: 69 (8)

In this Issue

August 2020, 69(8)
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  • Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
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