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Perspectives in Diabetes

Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19

  1. Franck Mauvais-Jarvis⇑
  1. Section of Endocrinology and Metabolism, John W. Deming Department of Medicine, Tulane University School of Medicine, and New Orleans VA Medical Center, New Orleans, LA
  1. Corresponding author: Franck Mauvais-Jarvis, fmauvais{at}tulane.edu
Diabetes 2020 Sep; 69(9): 1857-1863. https://doi.org/10.2337/dbi19-0023
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Abstract

Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biological, and molecular evidence to propose an unfolding paradigm in which old age, chronic metabolic disease (such as obesity, type 2 diabetes, and metabolic syndrome), and male biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic inflammation that intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. It is intended to inspire new research directions and stimulate funding in this field.

  • Received April 23, 2020.
  • Accepted June 11, 2020.
  • © 2020 by the American Diabetes Association
https://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

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Diabetes: 69 (9)

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September 2020, 69(9)
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Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19
Franck Mauvais-Jarvis
Diabetes Sep 2020, 69 (9) 1857-1863; DOI: 10.2337/dbi19-0023

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Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19
Franck Mauvais-Jarvis
Diabetes Sep 2020, 69 (9) 1857-1863; DOI: 10.2337/dbi19-0023
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