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Poster Presentations: Clinical Diabetes/Therapeutics

1368-P: Carbohydrate Intake Is Associated with OGTT Levels in Pregnancy

  1. EMILY ROSENBERG,
  2. KAITLYN JAMES,
  3. JULIANA ARENAS,
  4. MICHAEL J. CALLAHAN,
  5. MELODY CAYFORD,
  6. STACEY NELSON,
  7. SARAH N. BERNSTEIN,
  8. RAVI THADHANI,
  9. ELLEN W. SEELY and
  10. CAMILLE E. POWE
  1. Boston, MA
Diabetes 2020 Jun; 69(Supplement 1): -. https://doi.org/10.2337/db20-1368-P
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Abstract

Background: Traditionally, a carbohydrate-rich diet in the days preceding an oral glucose tolerance test (OGTT) has been recommended based on classic studies in non-pregnant individuals showing that carbohydrate restriction elevates post-load glucose levels. Instructions on carbohydrate intake given to pregnant women having an OGTT for gestational diabetes (GDM) diagnosis vary. We tested if self-reported carbohydrate intake in pregnancy is associated with OGTT results.

Methods: Pregnant women (N=79) with ≥ 1 risk factor for GDM underwent a fasting 75 g OGTT at 24-30 wks gestation and completed a 24-hr dietary recall using a validated self-administered instrument. We tested for an association between carbohydrate intake in the 24 hrs preceding the OGTT and 1-hour OGTT glucose using linear regression, with adjustment for age, BMI, gestational age, race, and total caloric intake. We also tested for associations with 30-minute and 2-hour OGTT glucose and glucose area under the curve (AUC).

Results: Women with lower carbohydrate intake (<median=235g) were slightly older (34 vs. 32 yrs, P=0.03), but otherwise similar to women with higher intake (BMI, history of GDM in a prior pregnancy, race/ethnicity, fasting glucose). We observed a graded linear relationship between carbohydrate intake and 1-hour OGTT glucose. For every 50 g reduction in carbohydrate intake, there was a 6.2 mg/dl increase in 1-hour OGTT glucose (β=6.2 mg/dl, P<0.01); this remained significant in the adjusted model (β=7.7 mg/dl, P=0.03). Lower carbohydrate intake was also associated with higher 30-minute (unadjusted β=4.4 mg/dl, P<0.01; adjusted β=6.7 mg/dl, P=0.02) and 2-hour OGTT glucose (unadjusted β=4.3 mg/dl, P=0.03; adjusted β=6.9 mg/dl, P=0.05) and glucose AUC (unadjusted β=513, P<0.01; adjusted β=683, P=0.03). Results did not change after excluding women with intake <1000 calories or when % carbohydrate intake was used as the predictor variable.

Conclusion: Carbohydrate restriction or excess before an OGTT may affect the diagnosis of GDM.

Disclosure E. Rosenberg: None. K. James: None. J. Arenas: None. M.J. Callahan: None. M. Cayford: None. S. Nelson: None. S.N. Bernstein: None. R. Thadhani: None. E.W. Seely: None. C.E. Powe: None.

Funding National Institutes of Health (K23DK113218); Robert Wood Johnson Foundation; Harold Amos Medical Faculty Development Award (72456)

  • © 2020 by the American Diabetes Association
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Diabetes: 69 (Supplement 1)

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June 2020, 69(Supplement 1)
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1368-P: Carbohydrate Intake Is Associated with OGTT Levels in Pregnancy
EMILY ROSENBERG, KAITLYN JAMES, JULIANA ARENAS, MICHAEL J. CALLAHAN, MELODY CAYFORD, STACEY NELSON, SARAH N. BERNSTEIN, RAVI THADHANI, ELLEN W. SEELY, CAMILLE E. POWE
Diabetes Jun 2020, 69 (Supplement 1) 1368-P; DOI: 10.2337/db20-1368-P

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1368-P: Carbohydrate Intake Is Associated with OGTT Levels in Pregnancy
EMILY ROSENBERG, KAITLYN JAMES, JULIANA ARENAS, MICHAEL J. CALLAHAN, MELODY CAYFORD, STACEY NELSON, SARAH N. BERNSTEIN, RAVI THADHANI, ELLEN W. SEELY, CAMILLE E. POWE
Diabetes Jun 2020, 69 (Supplement 1) 1368-P; DOI: 10.2337/db20-1368-P
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Poster Presentations: Clinical Diabetes/Therapeutics

  • 1374-P: Association between Number of Abnormal Glucose Values and Severity of Fasting Plasma Glucose in IADPSG Criteria and Pregnancy Outcomes in Pregnant Women in South India
  • 1369-P: Is Weight Loss after a Pregnancy Complicated by Diabetes Associated with Improved Subsequent Pregnancy Outcomes?
  • 1320-P: Building Trust between Researchers and African American and Latino Families of Children with T1D to Enhance Recruitment, Retention, and the Relevance of Research
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P: Pregnancy—Clinical/Epidemiology

  • 1343-P: Objectively Measured and Self-Reported Physical Activity in the First Trimester of Pregnancy, Glucose Tolerance, and Gestational Diabetes in Women with Overweight/Obesity
  • 1356-P: Can First-Trimester Glycated Hemoglobin Predict Gestational Diabetes Diagnosis?
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