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Poster Presentations: Clinical Diabetes/Therapeutics

880-P: Is Time-in-Range Independent of A1C? A Study in Asian Indian Population

  1. JOTHYDEV KESAVADEV,
  2. ARUN SHANKAR,
  3. GOPIKA KRISHNAN,
  4. BANSHI D. SABOO,
  5. GEETHU SANAL,
  6. MEERA KRISHNA B,
  7. SANAL TS and
  8. SUNITHA JOTHYDEV
  1. Trivandrum, India, Ahmedabad, India
Diabetes 2020 Jun; 69(Supplement 1): -. https://doi.org/10.2337/db20-880-P
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Abstract

Time-in-Range (TIR) has been recently established as a treatment target in diabetes to complement the time-tested A1c. Studies in the Caucasian population have shown that every 10% increase in TIR corresponds to 0.8% reduction in A1c. To study the relationship between TIR with A1c in the Asian-Indian population, CGM data from EMR of patients with type 1 and type 2 diabetes (n=424) followed up by a telemedicine program (DTMS) at our comprehensive diabetes care center in Kerala was obtained. Mann Whitney U test, t-test, ANOVA, and Pearson correlation coefficient were used for univariate analysis. Baseline characteristics were age 54 + 14 years, Gender frequency: F/M 127/297, diabetes duration 10.83+8.24 years, A1c 7.44+1.17 (%), eA1c 6.74+1.24 (%), and Average Blood Glucose (ABG) 146.96 + 35.62 (mg/dL). All the patients were eligible for a reduction of A1C <7.5%. In this subset of Asian-Indian population, our statistical analysis revealed that a TIR of >70% corresponds to an A1c level of <7.5% in agreement with the previous studies. In our telemedicine-based chronic care model, an A1c of <7.5% was achieved in 67.5% of the subjects. However only 36% achieved a TIR >70% and 66% achieved a TIR >60%; a finding which underscores the significance of TIR independent of A1c levels. The study suggests that TIR should evolve as a powerful target and predictor of diabetes complications and should be a routine measure in diabetes care.

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Disclosure J. Kesavadev: Speaker’s Bureau; Self; Biocon, Novo Nordisk Inc., Sanofi-Aventis. A. Shankar: None. G. Krishnan: None. B.D. Saboo: None. G. Sanal: None. M. Krishna B: None. S. Ts: None. S. Jothydev: None.

  • © 2020 by the American Diabetes Association
http://www.diabetesjournals.org/content/license

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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880-P: Is Time-in-Range Independent of A1C? A Study in Asian Indian Population
JOTHYDEV KESAVADEV, ARUN SHANKAR, GOPIKA KRISHNAN, BANSHI D. SABOO, GEETHU SANAL, MEERA KRISHNA B, SANAL TS, SUNITHA JOTHYDEV
Diabetes Jun 2020, 69 (Supplement 1) 880-P; DOI: 10.2337/db20-880-P

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880-P: Is Time-in-Range Independent of A1C? A Study in Asian Indian Population
JOTHYDEV KESAVADEV, ARUN SHANKAR, GOPIKA KRISHNAN, BANSHI D. SABOO, GEETHU SANAL, MEERA KRISHNA B, SANAL TS, SUNITHA JOTHYDEV
Diabetes Jun 2020, 69 (Supplement 1) 880-P; DOI: 10.2337/db20-880-P
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