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Perspectives in Diabetes

Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders

  1. Ritesh K. Baboota1,
  2. Matthias Blüher2 and
  3. Ulf Smith1⇑
  1. 1The Lundberg Laboratory for Diabetes Research, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
  2. 2Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Zentrum München, University of Leipzig and University Hospital Leipzig, Leipzig, Germany
  1. Corresponding author: Ulf Smith, ulf.smith{at}medic.gu.se
Diabetes 2021 Feb; 70(2): 303-312. https://doi.org/10.2337/db20-0884
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Abstract

Bone morphogenetic proteins (BMPs) are a group of signaling molecules that belong to the TGF-β superfamily. Initially discovered for their ability to induce bone formation, BMPs are known to play a diverse and critical array of biological roles. We here focus on recent evidence showing that BMP4 is an important regulator of white/beige adipogenic differentiation with important consequences for thermogenesis, energy homeostasis, and development of obesity in vivo. BMP4 is highly expressed in, and released by, human adipose tissue, and serum levels are increased in obesity. Recent studies have now shown BMP4 to play an important role not only for white/beige/brown adipocyte differentiation and thermogenesis but also in regulating systemic glucose homeostasis and insulin sensitivity. It also has important suppressive effects on hepatic glucose production and lipid metabolism. Cellular BMP4 signaling/action is regulated by both ambient cell/systemic levels and several endogenous and systemic BMP antagonists. Reduced BMP4 signaling/action can contribute to the development of obesity, insulin resistance, and associated metabolic disorders. In this article, we summarize the pleiotropic functions of BMP4 in the pathophysiology of these diseases and also consider the therapeutic implications of targeting BMP4 in the prevention/treatment of obesity and its associated complications.

  • Received August 31, 2020.
  • Accepted November 6, 2020.
  • © 2021 by the American Diabetes Association
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Diabetes: 70 (2)

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February 2021, 70(2)
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Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders
Ritesh K. Baboota, Matthias Blüher, Ulf Smith
Diabetes Feb 2021, 70 (2) 303-312; DOI: 10.2337/db20-0884

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Emerging Role of Bone Morphogenetic Protein 4 in Metabolic Disorders
Ritesh K. Baboota, Matthias Blüher, Ulf Smith
Diabetes Feb 2021, 70 (2) 303-312; DOI: 10.2337/db20-0884
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