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Pharmacology and Therapeutics

SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial

  1. Katrine M. Lauritsen1,2,3,
  2. Bent R.R. Nielsen4,
  3. Lars P. Tolbod5,
  4. Mogens Johannsen6,
  5. Jakob Hansen6,
  6. Troels K. Hansen1,
  7. Henrik Wiggers4,
  8. Niels Møller1,2,
  9. Lars C. Gormsen5 and
  10. Esben Søndergaard1,2,3⇑
  1. 1Steno Diabetes Center, Aarhus, Denmark
  2. 2Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
  3. 3Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
  4. 4Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
  5. 5Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus Denmark
  6. 6Department of Forensic Medicine, Aarhus University, Aarhus, Denmark
  1. Corresponding author: Esben Søndergaard, esben.sondergaard{at}clin.au.dk
  1. L.C.G. and E.S. contributed equally to the work.

Diabetes 2021 Mar; 70(3): 800-808. https://doi.org/10.2337/db20-0921
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Article Information

vol. 70 no. 3 800-808
DOI 
https://doi.org/10.2337/db20-0921
PubMed 
33334875

Published By 
American Diabetes Association
Print ISSN 
0012-1797
Online ISSN 
1939-327X
History 
  • Received September 11, 2020
  • Accepted December 14, 2020
  • Published in print February 19, 2021.
  • Published online ahead of print December 17, 2020.

Article Versions

  • Previous version (December 17, 2020 - 14:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2021 by the American Diabetes Association https://www.diabetesjournals.org/content/licenseReaders may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at https://www.diabetesjournals.org/content/license.

Author Information

  1. Katrine M. Lauritsen1,2,3,
  2. Bent R.R. Nielsen4,
  3. Lars P. Tolbod5,
  4. Mogens Johannsen6,
  5. Jakob Hansen6,
  6. Troels K. Hansen1,
  7. Henrik Wiggers4,
  8. Niels Møller1,2,
  9. Lars C. Gormsen5 and
  10. Esben Søndergaard1,2,3⇑
  1. 1Steno Diabetes Center, Aarhus, Denmark
  2. 2Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
  3. 3Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
  4. 4Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
  5. 5Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus Denmark
  6. 6Department of Forensic Medicine, Aarhus University, Aarhus, Denmark
  1. Corresponding author: Esben Søndergaard, esben.sondergaard{at}clin.au.dk
  1. L.C.G. and E.S. contributed equally to the work.

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SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial
Katrine M. Lauritsen, Bent R.R. Nielsen, Lars P. Tolbod, Mogens Johannsen, Jakob Hansen, Troels K. Hansen, Henrik Wiggers, Niels Møller, Lars C. Gormsen, Esben Søndergaard
Diabetes Mar 2021, 70 (3) 800-808; DOI: 10.2337/db20-0921

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SGLT2 Inhibition Does Not Affect Myocardial Fatty Acid Oxidation or Uptake, but Reduces Myocardial Glucose Uptake and Blood Flow in Individuals With Type 2 Diabetes: A Randomized Double-Blind, Placebo-Controlled Crossover Trial
Katrine M. Lauritsen, Bent R.R. Nielsen, Lars P. Tolbod, Mogens Johannsen, Jakob Hansen, Troels K. Hansen, Henrik Wiggers, Niels Møller, Lars C. Gormsen, Esben Søndergaard
Diabetes Mar 2021, 70 (3) 800-808; DOI: 10.2337/db20-0921
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